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This study aimed to gain insights into the patient-, disease-, and treatment characteristics, as well as the clinical outcomes of NSTI patients in the Netherlands, contributing to the global knowledge of this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed the NSTI Knowledge Project cohort, comprising 271 patients who were treated for acute NSTI in 11 hospitals across the Netherlands between 2013 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients (61%) presented with early-stage NSTI symptoms, such as pain or erythema. Intensive care unit admission was required in 83%, with a median stay of 5 days (interquartile range 2\u201311). The median time from hospital admission to debridement was 8\u00a0h (interquartile range 4\u201323). Group A Streptococcus was cultured in 41% of patients. Extremity amputation was required in 12%, and the in-hospital mortality rate was 21%. Patients presenting with early-stage symptoms who were misdiagnosed (60%) had a significantly higher in-hospital mortality rate (30%) than those correctly diagnosed (10%; p\u2009=\u2009\n                      <jats:italic>.003<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the Netherlands, NSTI patient and disease characteristics vary considerably. With one in five patients dying and one in eight patients undergoing a major amputation, interventions leading to rapid diagnosis and treatment are urgently needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00068-025-03000-8","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:56:40Z","timestamp":1761649000000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics, treatments, and outcomes of patients with necrotizing soft tissue infections: a Dutch multicenter cohort study"],"prefix":"10.1007","volume":"51","author":[{"given":"Jesse","family":"de Haan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidewij M.F.H.","family":"Neeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaco","family":"Suijker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P.M.","family":"van Zuijlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Pijpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annebeth","family":"Meij-de Vries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NSTI Knowledge Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap","family":"Bonjer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne K.","family":"Nieuwenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis H.","family":"van der Vlies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.M.","family":"van Lieshout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelis J.","family":"Ponsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"Terra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieta","family":"Krijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico L.","family":"Sosef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Winkelhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve M.M.","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas A.","family":"Twigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisca","family":"Wurfbain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"3000_CR1","doi-asserted-by":"publisher","DOI":"10.1136\/BMJOPEN-2020-041302","volume":"10","author":"M Hedetoft","year":"2020","unstructured":"Hedetoft M, Madsen MB, Madsen LB, Hyldegaard O. 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