{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:00:43Z","timestamp":1777982443465,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Trauma Emerg Surg"],"DOI":"10.1007\/s00068-026-03086-8","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T12:04:45Z","timestamp":1771243485000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Saline solution vs. stabilized isotonic sodium hypochlorite lavage in complicated appendicitis: a comparative study"],"prefix":"10.1007","volume":"52","author":[{"given":"Milton Alberto","family":"Mu\u00f1oz-Leija","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion Carolina","family":"Alem\u00e1n-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Gonz\u00e1lez-Lemus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal Dario","family":"Mart\u00ednez-Carvajal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u00fal","family":"T\u00f3var-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Quiroga-Garza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando Magdaleno","family":"Joya-Mungu\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heliodoro","family":"Plata-\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"3086_CR1","doi-asserted-by":"publisher","first-page":"CD010168","DOI":"10.1002\/14651858.cd010168.pub2","volume":"2","author":"Y Cheng","year":"2015","unstructured":"Cheng Y, Zhou S, Zhou R, et al. Abdominal drainage to prevent intra-peritoneal abscess after open appendectomy for complicated appendicitis. CDSR. 2015;2:CD010168. https:\/\/doi.org\/10.1002\/14651858.cd010168.pub2.","journal-title":"CDSR"},{"key":"3086_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd009022.pub2","volume":"11","author":"H Rehman","year":"2011","unstructured":"Rehman H, Rao AM, Ahmed I. Single incision versus conventional multi-incision appendicectomy for suspected appendicitis. CDSR. 2011;11:CD009022. https:\/\/doi.org\/10.1002\/14651858.cd009022.pub2.","journal-title":"CDSR"},{"key":"3086_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd008359.pub2","volume":"4","author":"IM Wilms","year":"2011","unstructured":"Wilms IM, Hoog DE, Visser DC, Janzing HM. Appendectomy versus antibiotic treatment for acute appendicitis. CDSR. 2011;4:CD015038. https:\/\/doi.org\/10.1002\/14651858.cd008359.pub2.","journal-title":"CDSR"},{"issue":"5","key":"3086_CR4","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1093\/oxfordjournals.aje.a115734","volume":"132","author":"DG Addiss","year":"1990","unstructured":"Addiss DG, Shaffer N, Fowler BS, Tauxe RV. THE EPIDEMIOLOGY OF APPENDICITIS AND APPENDECTOMY IN THE UNITED STATES. Am J Epidemiol. 1990;132(5):910\u201325. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a115734.","journal-title":"Am J Epidemiol"},{"issue":"2","key":"3086_CR5","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2188\/jea.je20090011","volume":"20","author":"JH Lee","year":"2010","unstructured":"Lee JH, Park YS, Choi JS. The epidemiology of appendicitis and appendectomy in South Korea: national registry data. J Epidemiol. 2010;20(2):97\u2013105. https:\/\/doi.org\/10.2188\/jea.je20090011.","journal-title":"J Epidemiol"},{"issue":"1","key":"3086_CR6","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s00268-016-3688-6","volume":"41","author":"S Kotaluoto","year":"2016","unstructured":"Kotaluoto S, Ukkonen M, Pauniaho SL, et al. Mortality related to Appendectomy; a population based analysis over two decades in Finland. World J Surg. 2016;41(1):64\u20139. https:\/\/doi.org\/10.1007\/s00268-016-3688-6.","journal-title":"World J Surg"},{"key":"3086_CR7","doi-asserted-by":"publisher","unstructured":"Lin KB, Lai KR, Yang NP, et al. Trends and outcomes in the utilization of laparoscopic appendectomies in a low-income population in Taiwan from 2003 to 2011. Int J Equity Health. 2015;14(1). https:\/\/doi.org\/10.1186\/s12939-015-0248-x.","DOI":"10.1186\/s12939-015-0248-x"},{"issue":"1","key":"3086_CR8","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-018-0179-0","volume":"13","author":"M Sartelli","year":"2018","unstructured":"Sartelli M, Baiocchi GL, Di Saverio S, et al. Prospective observational study on acute Appendicitis Worldwide (POSAW). World J Emerg Surg. 2018;13(1):19. https:\/\/doi.org\/10.1186\/s13017-018-0179-0.","journal-title":"World J Emerg Surg"},{"issue":"12","key":"3086_CR9","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1016\/j.jpedsurg.2019.08.039","volume":"54","author":"RM Nataraja","year":"2019","unstructured":"Nataraja RM, Panabokke G, Chang AD, et al. Does peritoneal lavage influence the rate of complications following pediatric Laparoscopic Appendicectomy in Children with Complicated Appendicitis? A prospective randomized clinical trial. J Pediatr Surg. 2019;54(12):2524\u20137. https:\/\/doi.org\/10.1016\/j.jpedsurg.2019.08.039.","journal-title":"J Pediatr Surg"},{"issue":"3","key":"3086_CR10","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.26820\/reciamuc\/3.(3).julio.2019.1191-1213","volume":"3","author":"JA Gonz\u00e1lez-Macas","year":"2019","unstructured":"Gonz\u00e1lez-Macas JA, Rugel-Zerna EV, Casa G\u00f3mez PY, et al. Complicaciones postoperatorias En Los Pacientes sometidos a cirug\u00eda de apendicitis Aguda. RECIAMUC. 2019;3(3):1191\u2013213. https:\/\/doi.org\/10.26820\/reciamuc\/3.(3).julio.2019.1191-1213.","journal-title":"RECIAMUC"},{"issue":"12","key":"3086_CR11","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1016\/j.jpedsurg.2008.08.051","volume":"43","author":"SD St Peter","year":"2008","unstructured":"St Peter SD, Sharp SW, Holcomb GW, Ostlie DJ. An evidence-based definition for perforated appendicitis derived from a prospective randomized trial. J Pediatr Surg. 2008;43(12):2242\u20135. https:\/\/doi.org\/10.1016\/j.jpedsurg.2008.08.051.","journal-title":"J Pediatr Surg"},{"issue":"1","key":"3086_CR12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1177\/000313481107700126","volume":"77","author":"CB Moore","year":"2011","unstructured":"Moore CB, Smith RS, Herbertson R, Toevs C. Does use of intraoperative irrigation with open or laparoscopic appendectomy reduce post-operative intra-abdominal abscess? Am Surg. 2011;77(1):78\u201380. https:\/\/doi.org\/10.1177\/000313481107700126.","journal-title":"Am Surg"},{"issue":"4","key":"3086_CR13","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.0954-6820.1967.tb10875.x","volume":"182","author":"J Gjessing","year":"1967","unstructured":"Gjessing J. Bacterial growth in the dialysate fluid and the reaction of peritoneum to peritoneal dialysis. Acta Med Scand. 1967;182(4):509\u201312. https:\/\/doi.org\/10.1111\/j.0954-6820.1967.tb10875.x.","journal-title":"Acta Med Scand"},{"issue":"6","key":"3086_CR14","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1089\/sur.2016.158","volume":"17","author":"CE Edmiston Jr","year":"2016","unstructured":"Edmiston CE Jr, Leaper DJ. Intra-operative surgical irrigation of the surgical incision: what does the future hold-saline, antibiotic agents, or antiseptic agents? Surg Infect. 2016;17(6):656\u201364. https:\/\/doi.org\/10.1089\/sur.2016.158.","journal-title":"Surg Infect"},{"issue":"1","key":"3086_CR15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/bjs5.50118","volume":"3","author":"E Gammeri","year":"2018","unstructured":"Gammeri E, Petrinic T, Bond-Smith G, Gordon-Weeks A. Meta-analysis of peritoneal lavage in appendicectomy. BJS Open. 2018;3(1):24\u201330. https:\/\/doi.org\/10.1002\/bjs5.50118.","journal-title":"BJS Open"},{"issue":"1","key":"3086_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-023-00496-6","volume":"18","author":"Q Zhou","year":"2023","unstructured":"Zhou Q, Meng W, Ren Y, et al. Effectiveness of intraoperative peritoneal lavage with saline in patient with intra-abdominal infections: a systematic review and meta-analysis. World J Emerg Surg. 2023;18(1):24. https:\/\/doi.org\/10.1186\/s13017-023-00496-6.","journal-title":"World J Emerg Surg"},{"issue":"5","key":"3086_CR17","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/00004630-199109000-00005","volume":"12","author":"JP Heggers","year":"1991","unstructured":"Heggers JP, Sazy JA, Stenberg BD, et al. Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg award. J Burn Care Rehabil. 1991;12(5):420\u20134. https:\/\/doi.org\/10.1097\/00004630-199109000-00005.","journal-title":"J Burn Care Rehabil"},{"issue":"9","key":"3086_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091395","volume":"11","author":"L Ortega-Llamas","year":"2022","unstructured":"Ortega-Llamas L, Qui\u00f1ones-Vico MI, Garc\u00eda-Valdivia M, et al. Cytotoxicity and wound closure evaluation in skin cell lines after treatment with common antiseptics for clinical use. Cells. 2022;11(9):1395. https:\/\/doi.org\/10.3390\/cells11091395.","journal-title":"Cells"},{"key":"3086_CR19","unstructured":"Anacapa Technologies. Anasept antimicrobial skin & wound cleanser. anasept Antimicrobial skin and wound care products. http:\/\/static.webareacontrol.com\/CommonFile\/anacapa-anasept-antimicrobialskinandwoundcleanser-1699938167212.pdf. Accessed 22 July 2025."},{"key":"3086_CR20","unstructured":"Federal Drug Administration. Device: Anasept\u2122 Antimicrobial Skin and Wound Gel Section D: 510(K) Summary Anacapa\u2122 Technologies, Inc. 510(k) Premarket Notification.  https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf7\/K073547.pdf.\u00a0Accessed 22 July 2025."},{"issue":"Sup2","key":"3086_CR21","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.12968\/jowc.2022.31.Sup2.S32","volume":"31","author":"TE Serena","year":"2022","unstructured":"Serena TE, Serena L, Al-Jalodi O, et al. The efficacy of sodium hypochlorite antiseptic: a double-blind, randomised controlled pilot study. J Wound Care. 2022;31(Sup2):S32\u20135. https:\/\/doi.org\/10.12968\/jowc.2022.31.Sup2.S32.","journal-title":"J Wound Care"},{"issue":"1","key":"3086_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-021-00387-8","volume":"16","author":"M Sartelli","year":"2021","unstructured":"Sartelli M, Coccolini F, Kluger Y, et al. WSES\/GAIS\/SIS-E\/WSIS\/AAST global clinical pathways for patients with intra-abdominal infections. World J Emerg Surg. 2021;16(1):49. https:\/\/doi.org\/10.1186\/s13017-021-00387-8.","journal-title":"World J Emerg Surg"},{"issue":"1","key":"3086_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-024-00551-w","volume":"19","author":"M Sartelli","year":"2024","unstructured":"Sartelli M, Tascini C, Coccolini F, et al. Management of intra-abdominal infections: recommendations by the Italian council for the optimization of antimicrobial use. World J Emerg Surg. 2024;19(1):23. https:\/\/doi.org\/10.1186\/s13017-024-00551-w.","journal-title":"World J Emerg Surg"},{"issue":"2","key":"3086_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1089\/sur.2018.282","volume":"20","author":"TG Weiser","year":"2019","unstructured":"Weiser TG, Forrester JD, Forrester JA. Tactics to prevent intra-abdominal infections in general surgery. Surg Infect. 2019;20(2):139\u201345. https:\/\/doi.org\/10.1089\/sur.2018.282.","journal-title":"Surg Infect"},{"issue":"2","key":"3086_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00423-015-1279-x","volume":"400","author":"TC Mueller","year":"2015","unstructured":"Mueller TC, Loos M, Haller B, et al. Intra-operative wound irrigation to reduce surgical site infections after abdominal surgery: a systematic review and meta-analysis. Langenbecks Arch Surg. 2015;400(2):167\u201381. https:\/\/doi.org\/10.1007\/s00423-015-1279-x.","journal-title":"Langenbecks Arch Surg"},{"issue":"10","key":"3086_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20728","volume":"9","author":"FV Rheinbaben","year":"2023","unstructured":"Rheinbaben FV, K\u00f6hnlein J, Schmidt N, Hildebrandt C, Werner S. To reduce cytotoxicity when testing the virucidal activity of chemical disinfectants and biocides: the \u201cT-25 method\u201d as an alternative to \u201clarge-volume-plating.\u201d Heliyon. 2023;9(10):e20728. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20728.","journal-title":"Heliyon"},{"issue":"1","key":"3086_CR27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.33235\/wcet.43.1.35-40","volume":"43","author":"E Haesler","year":"2023","unstructured":"Haesler E, Carville K. WHAM evidence summary: traditional hypochlorite solutions. WCET J. 2023;43(1):35\u201340. https:\/\/doi.org\/10.33235\/wcet.43.1.35-40.","journal-title":"WCET J"},{"issue":"8","key":"3086_CR28","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s001130050318","volume":"101","author":"W Fleischmann","year":"1998","unstructured":"Fleischmann W, Russ M, Westhauser A, Stampehl M. Vacuum-sealing-technique used as drug release system for topical treatment of wound infections. Unfallchirurg. 1998;101(8):649\u201354. https:\/\/doi.org\/10.1007\/s001130050318.","journal-title":"Unfallchirurg"},{"issue":"3","key":"3086_CR29","doi-asserted-by":"publisher","first-page":"209","DOI":"10.4321\/s0376-78922013000300001","volume":"39","author":"A Garc\u00eda-Ruano","year":"2013","unstructured":"Garc\u00eda-Ruano A, Garc\u00eda-Fern\u00e1ndez S, Mahedero-Navarrete S, Lasso-V\u00e1zquez JM, P\u00e9rez-Cano R. Innovador Tratamiento de Heridas abdominales Complejas mediante terapia de presi\u00f3n negativa Con instilaci\u00f3n intermitente. Cir Plast Iberolatinoam. 2013;39(3):209\u201317. https:\/\/doi.org\/10.4321\/s0376-78922013000300001.","journal-title":"Cir Plast Iberolatinoam"},{"key":"3086_CR30","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.amsu.2018.10.007","volume":"36","author":"P Sibaja-\u00c1lvarez","year":"2018","unstructured":"Sibaja-\u00c1lvarez P, S\u00e1nchez-Betancourt A, Fern\u00e1ndez LG. Negative pressure wound therapy with instillation in the septic open abdomen utilizing a modified negative pressure therapy system. Ann Med Surg (Lond). 2018;36:246\u201351. https:\/\/doi.org\/10.1016\/j.amsu.2018.10.007.","journal-title":"Ann Med Surg (Lond)"},{"issue":"1","key":"3086_CR31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13017-016-0090-5","volume":"11","author":"S Di Saverio","year":"2016","unstructured":"Di Saverio S, Birindelli A, Kelly MD, et al. WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016;11(1):34. https:\/\/doi.org\/10.1186\/s13017-016-0090-5.","journal-title":"World J Emerg Surg"}],"container-title":["European Journal of Trauma and Emergency Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-026-03086-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00068-026-03086-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00068-026-03086-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T17:10:04Z","timestamp":1771434604000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00068-026-03086-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,16]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3086"],"URL":"https:\/\/doi.org\/10.1007\/s00068-026-03086-8","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7482183\/v1","asserted-by":"object"}]},"ISSN":["1863-9941"],"issn-type":[{"value":"1863-9941","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,16]]},"assertion":[{"value":"28 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This project was evaluated and approved by the corresponding ethics committee and the corresponding research committee. Both committes assigned the approval number R-2024-1912-028.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Written informed consent was obtained from all participants or their legal representatives for publication data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}