{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:13:55Z","timestamp":1767827635620,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T00:00:00Z","timestamp":1481241600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesist"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1007\/s00101-016-0249-1","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T09:15:01Z","timestamp":1481274901000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gerinnungsfaktor\u00a0XIII","Factor\u00a0XIII"],"prefix":"10.1007","volume":"66","author":[{"given":"E. H.","family":"Adam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kreuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Zacharowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wildenauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"249_CR1","doi-asserted-by":"publisher","unstructured":"Bundes\u00e4rztekammer (2016) Cross-sectional guidelines for therapy with blood components and plasma derivatives: Chapter 5 Human albumin\u00a0\u2013 revised. Transfus Med Hemother 43(3):223\u2013232. doi: 10.1159\/000446043","DOI":"10.1159\/000446043"},{"key":"249_CR2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1182\/blood-2008-09-179333","volume":"113","author":"E Ajzner","year":"2009","unstructured":"Ajzner E, Schlammadinger A, Kerenyi A et\u00a0al (2009) Severe bleeding complications caused by an autoantibody against the B subunit of plasma factor XIII: a\u00a0novel form of acquired factor XIII deficiency. Blood 113:723\u2013725","journal-title":"Blood"},{"key":"249_CR3","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/hae.12524","volume":"21","author":"C Ashley","year":"2015","unstructured":"Ashley C, Chang E, Davis J et al (2015) Efficacy and safety of prophylactic treatment with plasma-derived factor XIII concentrate (human) in patients with congenital factor XIII deficiency. Haemophilia 21:102\u2013108","journal-title":"Haemophilia"},{"key":"249_CR4","volume-title":"Fachinformation Fibrogammin\u00ae 250\/1250","author":"Behring","year":"2015","unstructured":"Behring (2015) Fachinformation Fibrogammin\u00ae 250\/1250"},{"key":"249_CR5","doi-asserted-by":"crossref","first-page":"e00227","DOI":"10.1002\/prp2.227","volume":"4","author":"A Beyerle","year":"2016","unstructured":"Beyerle A, Solomon C, Dickneite G et al (2016) Nonclinical analysis of the safety, pharmacodynamics, and pharmacokinetics of plasma-derived human FXIII concentrate in animals. Pharmacol Res Perspect 4:e00227","journal-title":"Pharmacol Res Perspect"},{"key":"249_CR6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5482\/HAMO-13-08-0046","volume":"34","author":"A Biswas","year":"2014","unstructured":"Biswas A, Ivaskevicius V, Thomas A et\u00a0al (2014) Coagulation factor XIII deficiency. Diagnosis, prevalence and management of inherited and acquired forms. Hamostaseologie 34:160\u2013166","journal-title":"Hamostaseologie"},{"key":"249_CR7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0268-960X(93)90010-2","volume":"7","author":"PG Board","year":"1993","unstructured":"Board PG, Losowsky MS, Miloszewski KJ (1993) Factor XIII: inherited and acquired deficiency. Blood Rev 7:229\u2013242","journal-title":"Blood Rev."},{"key":"249_CR8","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1055\/s-0038-1649787","volume":"74","author":"HH Brackmann","year":"1995","unstructured":"Brackmann HH, Egbring R, Ferster A et\u00a0al (1995) Pharmacokinetics and tolerability of factor XIII concentrates prepared from human placenta or plasma: a\u00a0crossover randomised study. Thromb Haemost 74:622\u2013625","journal-title":"Thromb. Haemost."},{"key":"249_CR9","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1055\/s-0038-1666935","volume":"42","author":"BN Dardik","year":"1979","unstructured":"Dardik BN, Shainoff JR (1979) Crosslinking of monomeric fibrin by factor XIIIa. Thromb Haemost 42:864\u2013872","journal-title":"Thromb. Haemost."},{"key":"249_CR10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0020-711X(92)90234-R","volume":"24","author":"C Backer-Royer De","year":"1992","unstructured":"De Backer-Royer C, Traore F, Meunier JC (1992) Purification and properties of factor XIII from human placenta. Int J Biochem 24:91\u201397","journal-title":"Int. J. Biochem."},{"key":"249_CR11","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1160\/TH14-07-0625","volume":"113","author":"G Dickneite","year":"2015","unstructured":"Dickneite G, Herwald H, Korte W et\u00a0al (2015) Coagulation factor XIII: a\u00a0multifunctional transglutaminase with clinical potential in a\u00a0range of conditions. Thromb Haemost 113:686\u2013697","journal-title":"Thromb. Haemost."},{"key":"249_CR12","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.blre.2016.06.002","volume":"30","author":"A Dorgalaleh","year":"2016","unstructured":"Dorgalaleh A, Rashidpanah J (2016) Blood coagulation factor XIII and factor XIII deficiency. Blood Rev 30:461. doi: 10.1016\/j.blre.2016.06.002","journal-title":"Blood Rev."},{"key":"249_CR13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1055\/s-0038-1654918","volume":"5","author":"F Duckert","year":"1960","unstructured":"Duckert F, Jung E, Shmerling DH (1960) A\u00a0hitherto undescribed congenital haemorrhagic diathesis probably due to fibrin stabilizing factor deficiency. Thromb Diath Haemorrh 5:179\u2013186","journal-title":"Thromb Diath Haemorrh"},{"key":"249_CR14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/hae.12137","volume":"19","author":"MA Escobar","year":"2013","unstructured":"Escobar MA (2013) Advances in the treatment of inherited coagulation disorders. Haemophilia 19:648\u2013659","journal-title":"Haemophilia"},{"key":"249_CR15","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V71.5.1361.1361","volume":"71","author":"CW Francis","year":"1988","unstructured":"Francis CW, Marder VJ (1988) Increased resistance to plasmic degradation of fibrin with highly crosslinked alpha-polymer chains formed at high factor XIII concentrations. Blood 71:1361\u20131365","journal-title":"Blood"},{"key":"249_CR16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s12185-012-1064-3","volume":"95","author":"A Ichinose","year":"2012","unstructured":"Ichinose A (2012) Factor XIII is a\u00a0key molecule at the intersection of coagulation and fibrinolysis as well as inflammation and infection control. Int J Hematol 95:362\u2013370","journal-title":"Int. J. Hematol."},{"key":"249_CR17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0076-6879(93)22006-2","volume":"222","author":"A Ichinose","year":"1993","unstructured":"Ichinose A, Kaetsu H (1993) Molecular approach to structure-function relationship of human coagulation factor XIII. Meth Enzymol 222:36\u201351","journal-title":"Meth. Enzymol."},{"key":"249_CR18","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1111\/jth.12739","volume":"12","author":"B Kerlin","year":"2014","unstructured":"Kerlin B, Brand B, Inbal A et al (2014) Pharmacokinetics of recombinant factor XIII at steady state in patients with congenital factor XIII A\u2011subunit deficiency. J Thromb Haemost 12:2038\u20132043","journal-title":"J. Thromb. Haemost."},{"key":"249_CR19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/EJA.0b013e32835f4d5b","volume":"30","author":"SA Kozek-Langenecker","year":"2013","unstructured":"Kozek-Langenecker SA, Afshari A, Albaladejo P et al (2013) Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology. Eur J Anaesthesiol 30:270\u2013382","journal-title":"Eur J Anaesthesiol"},{"key":"249_CR20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1126\/science.108.2802.280","volume":"108","author":"K Laki","year":"1948","unstructured":"Laki K, Lorand L (1948) On the solubility of fibrin clots. Science 108:280","journal-title":"Science"},{"key":"249_CR21","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1537-2995.2012.03865.x","volume":"53","author":"JH Levy","year":"2013","unstructured":"Levy JH, Greenberg C (2013) Biology of Factor XIII and clinical manifestations of Factor XIII deficiency. Transfusion 53:1120\u20131131","journal-title":"Transfusion"},{"key":"249_CR22","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1182\/blood-2011-02-337568","volume":"118","author":"TG Loof","year":"2011","unstructured":"Loof TG, Morgelin M, Johansson L et\u00a0al (2011) Coagulation, an ancestral serine protease cascade, exerts a\u00a0novel function in early immune defense. Blood 118:2589\u20132598","journal-title":"Blood"},{"key":"249_CR23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1182\/blood-2005-02-0788","volume":"108","author":"AE Lovejoy","year":"2006","unstructured":"Lovejoy AE, Reynolds TC, Visich JE et al (2006) Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency. Blood 108:57\u201362","journal-title":"Blood"},{"key":"249_CR24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1365-2516.2009.02123.x","volume":"16","author":"J Lusher","year":"2010","unstructured":"Lusher J, Pipe SW, Alexander S et\u00a0al (2010) Prophylactic therapy with Fibrogammin P is associated with a\u00a0decreased incidence of bleeding episodes: a\u00a0retrospective study. Haemophilia 16:316\u2013321","journal-title":"Haemophilia"},{"key":"249_CR25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00001721-199707000-00001","volume":"8","author":"MW Mosesson","year":"1997","unstructured":"Mosesson MW (1997) Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coagul Fibrinolysis 8:257\u2013267","journal-title":"Blood Coagul Fibrinolysis"},{"key":"249_CR26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/10408369609084691","volume":"33","author":"L Muszbek","year":"1996","unstructured":"Muszbek L, Adany R, Mikkola H (1996) Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, and function. Crit Rev Clin Lab Sci 33:357\u2013421","journal-title":"Crit Rev Clin Lab Sci"},{"key":"249_CR27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1152\/physrev.00016.2010","volume":"91","author":"L Muszbek","year":"2011","unstructured":"Muszbek L, Bereczky Z, Bagoly Z et\u00a0al (2011) Factor XIII: a\u00a0coagulation factor with multiple plasmatic and cellular functions. Physiol Rev 91:931\u2013972","journal-title":"Physiol. Rev."},{"issue":"Suppl 2","key":"249_CR28","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0049-3848(13)70005-7","volume":"130","author":"D Nugent","year":"2012","unstructured":"Nugent D (2012) Corifact\/Fibrogammin(R) P in the prophylactic treatment of hereditary factor XIII deficiency: results of a\u00a0prospective, multicenter, open-label study. Thromb Res 130(Suppl 2):S12\u2013S14","journal-title":"Thromb. Res."},{"key":"249_CR29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/hae.12505","volume":"21","author":"DJ Nugent","year":"2015","unstructured":"Nugent DJ, Ashley C, Garcia-Talavera J et al (2015) Pharmacokinetics and safety of plasma-derived factor XIII concentrate (human) in patients with congenital factor XIII deficiency. Haemophilia 21:95\u2013101","journal-title":"Haemophilia"},{"key":"249_CR30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MBC.0000000000000029","volume":"25","author":"JE Odame","year":"2014","unstructured":"Odame JE, Chan AK, Wu JK et\u00a0al (2014) Factor XIII deficiency management: a\u00a0review of the literature. Blood Coagul Fibrinolysis 25:199\u2013205","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"Suppl 4","key":"249_CR31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/hae.12428","volume":"20","author":"J Oldenburg","year":"2014","unstructured":"Oldenburg J, Albert T (2014) Novel products for haemostasis \u2013 current status. Haemophilia 20(Suppl 4):23\u201328","journal-title":"Haemophilia"},{"key":"249_CR32","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/hae.12786","volume":"22","author":"K Penzes","year":"2015","unstructured":"Penzes K, Vezina C, Bereczky Z et\u00a0al (2015) Alloantibody developed in a\u00a0factor XIII A\u00a0subunit deficient patient during substitution therapy; characterization of the antibody. Haemophilia 22:268. doi: 10.1111\/hae.12786","journal-title":"Haemophilia"},{"key":"249_CR33","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1538-7836.2012.04653.x","volume":"10","author":"F Peyvandi","year":"2012","unstructured":"Peyvandi F, Palla R, Menegatti M et\u00a0al (2012) Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders. J\u00a0Thromb Haemost 10:615\u2013621","journal-title":"J. Thromb. Haemost."},{"key":"249_CR34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13054-016-1265-x","volume":"20","author":"R Rossaint","year":"2016","unstructured":"Rossaint R, Bouillon B, Cerny V et\u00a0al (2016) The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 20:100","journal-title":"Crit Care"},{"key":"249_CR35","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1055\/s-0033-1353392","volume":"39","author":"V Schroeder","year":"2013","unstructured":"Schroeder V, Kohler HP (2013) Factor XIII deficiency: an update. Semin Thromb Hemost 39:632\u2013641","journal-title":"Semin. Thromb. Hemost."},{"key":"249_CR36","doi-asserted-by":"crossref","first-page":"278","DOI":"10.5858\/arpa.2012-0639-RS","volume":"138","author":"A Tahlan","year":"2014","unstructured":"Tahlan A, Ahluwalia J (2014) Factor XIII: congenital deficiency factor XIII, acquired deficiency, factor XIII A\u2011subunit, and factor XIII B\u2011subunit. Arch Pathol Lab Med 138:278\u2013281","journal-title":"Arch Pathol Lab Med"},{"key":"249_CR37","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1537-2995.2008.02063.x","volume":"49","author":"C Heymann Von","year":"2009","unstructured":"Von Heymann C, Keller MK, Spies C et al (2009) Activity of clotting factors in fresh-frozen plasma during storage at 4 degrees C over 6 days. Transfusion 49:913\u2013920","journal-title":"Transfusion"},{"key":"249_CR38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1055\/s-0041-105951","volume":"50","author":"CF Weber","year":"2015","unstructured":"Weber CF, Adam EH, Pape A et\u00a0al (2015) Coagulation factor XIII \u2013 Pathophysiology, clinic and therapy of factor XIII deficiency. Anasthesiol Intensivmed Notfallmed Schmerzther 50:684\u2013690","journal-title":"Anasthesiol Intensivmed Notfallmed Schmerzther"},{"key":"249_CR39","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood-2012-09-306639","volume":"121","author":"JW Weisel","year":"2013","unstructured":"Weisel JW, Litvinov RI (2013) Mechanisms of fibrin polymerization and clinical implications. Blood 121:1712\u20131719","journal-title":"Blood"},{"key":"249_CR40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.thromres.2006.02.003","volume":"119","author":"S Zeerleder","year":"2007","unstructured":"Zeerleder S, Schroeder V, Lammle B et\u00a0al (2007) Factor XIII in severe sepsis and septic shock. Thromb Res 119:311\u2013318","journal-title":"Thromb. Res."}],"container-title":["Der Anaesthesist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-016-0249-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00101-016-0249-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-016-0249-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T21:10:08Z","timestamp":1601241008000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00101-016-0249-1"}},"subtitle":["Pharmakodynamische und pharmakokinetische Eigenschaften","Pharmacodynamic and pharmacokinetic characteristics"],"short-title":[],"issued":{"date-parts":[[2016,12,9]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["249"],"URL":"https:\/\/doi.org\/10.1007\/s00101-016-0249-1","relation":{},"ISSN":["0003-2417","1432-055X"],"issn-type":[{"value":"0003-2417","type":"print"},{"value":"1432-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,9]]}}}