{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:15:14Z","timestamp":1775996114322,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesist"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00101-018-0532-4","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T03:47:15Z","timestamp":1548388035000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Perioperative Anwendung von Metamizol und anderen Nichtopioidanalgetika bei Kindern","Perioperative use of metamizole and other nonopioid analgesics in children"],"prefix":"10.1007","volume":"68","author":[{"given":"L.","family":"Witschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Reist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Stammschulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Erlenwein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Becke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Stamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"532_CR1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00228-014-1781-z","volume":"71","author":"LS Blaser","year":"2015","unstructured":"Blaser LS, Tramonti A, Egger P et\u00a0al (2015) Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports. Eur J Clin Pharmacol 71:209\u2013217","journal-title":"Eur J Clin Pharmacol"},{"key":"532_CR2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s001010050971","volume":"50","author":"DH Bremerich","year":"2001","unstructured":"Bremerich DH, Neidhart G, Roth B et\u00a0al (2001) Postoperative Schmerztherapie im Kindesalter. Ergenisse einer rep\u00e4sentativen Umfrage in Deutschland. Anaesthesist 50:102\u2013112","journal-title":"Anaesthesist"},{"key":"532_CR3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s11684-015-0414-y","volume":"9","author":"X Bu","year":"2015","unstructured":"Bu X, Yang L, Zuo Y (2015) Efficacy and safety of perioperative parecoxib for acute postoperative pain treatment in children: a\u00a0meta-analysis. Front Med 9:496\u2013507","journal-title":"Front Med"},{"key":"532_CR4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2253-13-34","volume":"13","author":"E Caliskan","year":"2013","unstructured":"Caliskan E, Sener M, Kocum A et al (2013) The efficacy of intravenous paracetamol versus dipyrone for postoperative analgesia after day-case lower abdominal surgery in children with spinal anesthesia: a\u00a0prospective randomized double-blind placebo-controlled study. BMC Anesthesiol 13:34","journal-title":"BMC Anesthesiol."},{"key":"532_CR5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/pan.13257","volume":"27","author":"TG Leeuw De","year":"2017","unstructured":"De Leeuw TG, Dirckx M, Gonzalez CA et\u00a0al (2017) The use of dipyrone (metamizol) as an analgesic in children: What is the evidence? A review. Paediatr Anaesth 27:1193\u20131201","journal-title":"Paediatr Anaesth"},{"key":"532_CR6","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/EJA.0000000000000272","volume":"32","author":"M Fieler","year":"2015","unstructured":"Fieler M, Eich C, Becke K et\u00a0al (2015) Metamizole for postoperative pain therapy in 1177 children: a prospective, multicentre, observational, postauthorisation safety study. Eur J Anaesthesiol 32:839\u2013843","journal-title":"Eur J Anaesthesiol"},{"key":"532_CR7","first-page":"46","volume":"40","author":"E Haen","year":"2013","unstructured":"Haen E, H\u00f6ffler D, Stammschulte T (2013) T\u00f6dliche Agranulozytose unter Novaminsulfon\u2014aus Fehlern lernen. Arzneiverordn Prax 40:46\u201347","journal-title":"Arzneiverordn Prax"},{"key":"532_CR8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00482-004-0318-2","volume":"19","author":"C Hunseler","year":"2005","unstructured":"Hunseler C, Roth B, Pothmann R et\u00a0al (2005) Intramuskul\u00e4re injektionen im Kindesalter. Schmerz 19:140\u2013143","journal-title":"Schmerz"},{"key":"532_CR9","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1097\/MPH.0b013e31826e7d9d","volume":"36","author":"M Isik","year":"2014","unstructured":"Isik M, Kaya Z, Belen FB et al (2014) Life-threatening agranulocytosis, anemia, and plasmacytosis after dipyrone use for fever in a\u00a0child. J\u00a0Pediatr Hematol Oncol 36:e46\u2013e48","journal-title":"J Pediatr Hematol Oncol"},{"key":"532_CR10","first-page":"28","volume":"5","author":"J K\u00f6bberling","year":"2017","unstructured":"K\u00f6bberling J, von Alpen R (2017) Metamizol und Agranulozytose \u2013 Aufkl\u00e4rungspflicht. Rheinisches Arztebl 5:28\u201329","journal-title":"Rheinisches Arztebl"},{"key":"532_CR11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5935\/1808-8694.20130015","volume":"79","author":"AI Kocum","year":"2013","unstructured":"Kocum AI, Sener M, Caliskan E et al (2013) Intravenous paracetamol and dipyrone for postoperative analgesia after day-case tonsillectomy in children: a\u00a0prospective, randomized, double blind, placebo controlled study. Braz J Otorhinolaryngol 79:89\u201394","journal-title":"Braz J Otorhinolaryngol"},{"key":"532_CR12","doi-asserted-by":"crossref","first-page":"e0122918","DOI":"10.1371\/journal.pone.0122918","volume":"10","author":"T Kotter","year":"2015","unstructured":"Kotter T, Da Costa BR, Fassler M et al (2015) Metamizole-associated adverse events: a\u00a0systematic review and meta-analysis. PLoS ONE 10:e122918","journal-title":"PLoS ONE"},{"key":"532_CR13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00482-013-1384-0","volume":"28","author":"B Messerer","year":"2014","unstructured":"Messerer B, Grogl G, Stromer W et\u00a0al (2014) Perioperative systemische Schmerztherapie bei Kindern: \u00d6sterreichische interdiszplin\u00e4re Handlungsempfehlungen zum perioperativen Schmerzmanagement bei Kindern. Schmerz 28:43\u201364","journal-title":"Schmerz"},{"key":"532_CR14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s12630-015-0376-1","volume":"62","author":"K Murto","year":"2015","unstructured":"Murto K, Lamontagne C, Mcfaul C et al (2015) Celecoxib pharmacogenetics and pediatric adenotonsillectomy: a\u00a0double-blinded randomized controlled study. Can J Anaesth 62:785\u2013797","journal-title":"Can. J. Anaesth."},{"key":"532_CR15","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/ejp.1194","volume":"22","author":"L Reist","year":"2018","unstructured":"Reist L, Erlenwein J, Meissner W et al (2018) Dipyrone is the preferred nonopioid analgesic for the treatment of acute and chronic pain. A survey of clinical practice in German-speaking countries. Eur J Pain 22:1103\u20131112","journal-title":"Eur J Pain"},{"key":"532_CR16","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1097\/EJA.0000000000000275","volume":"32","author":"V Rollason","year":"2015","unstructured":"Rollason V, Desmeules JA (2015) Use of metamizole in children and the risk of agranulocytosis: Is the benefit worth the risk? Eur J Anaesthesiol 32:837\u2013838","journal-title":"Eur J Anaesthesiol"},{"key":"532_CR17","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bjan.2013.09.009","volume":"65","author":"M Sener","year":"2015","unstructured":"Sener M, Kocum A, Caliskan E et al (2015) Administration of paracetamol versus dipyrone by intravenous patient-controlled analgesia for postoperative pain relief in children after tonsillectomy. Braz J Anesthesiol 65:476\u2013482","journal-title":"Braz J Anesthesiol"},{"key":"532_CR18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/EJA.0000000000000498","volume":"33","author":"MA Souki","year":"2016","unstructured":"Souki MA (2016) Metamizole for postoperative pain therapy. Eur J Anaesthesiol 33:785\u2013786","journal-title":"Eur J Anaesthesiol"},{"key":"532_CR19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00482-016-0160-3","volume":"31","author":"UM Stamer","year":"2017","unstructured":"Stamer UM, Gundert-Remy U, Biermann E et al (2017) Metamizol: \u00dcberlegungen zum Monitoring zur fr\u00fchzeitigen Diagnose einer Agranulozytose. Schmerz 31:5\u201313","journal-title":"Schmerz"},{"key":"532_CR20","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/pan.13456","volume":"28","author":"UM Stamer","year":"2018","unstructured":"Stamer UM, Stuber F (2018) Analgesic efficacy of dipyrone in children: still an absence of evidence. Paediatr Anaesth 28:748\u2013749","journal-title":"Paediatr Anaesth"},{"key":"532_CR21","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00228-015-1895-y","volume":"71","author":"T Stammschulte","year":"2015","unstructured":"Stammschulte T, Ludwig WD, Muhlbauer B et al (2015) Metamizole (dipyrone)-associated agranulocytosis. An analysis of German spontaneous reports 1990\u20132012. Eur J Clin Pharmacol 71:1129\u20131138","journal-title":"Eur J Clin Pharmacol"},{"key":"532_CR22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-0036-1587332","volume":"27","author":"R S\u00fcmpelmann","year":"2017","unstructured":"S\u00fcmpelmann R, Fieler M, Eich C et\u00a0al (2017) Metamizole for postoperative pain therapy in infants younger than 1 year. Eur J Pediatr Surg 27:269\u2013273","journal-title":"Eur J Pediatr Surg"},{"key":"532_CR23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/08880018.2013.874512","volume":"31","author":"B Tavil","year":"2014","unstructured":"Tavil B, Cetin M, Gumruk F et al (2014) Metamizole-induced bicytopenia reversed by G\u2011CSF and IVIG treatment in a\u00a0child. Pediatr Hematol Oncol 31:117\u2013119","journal-title":"Pediatr Hematol Oncol"},{"key":"532_CR24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12642-010-0030-y","volume":"50","author":"H Treiblmaier","year":"2011","unstructured":"Treiblmaier H (2011) Datenqualit\u00e4t und Validit\u00e4t bei Online-Befragungen. Markt 50:3\u201318","journal-title":"Markt"},{"key":"532_CR25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-0609.1996.tb01651.x","volume":"60","author":"JP Uetrecht","year":"1996","unstructured":"Uetrecht JP (1996) Reactive metabolites and agranulocytosis. Eur J Haematol Suppl 60:83\u201388","journal-title":"Eur J Haematol Suppl"},{"key":"532_CR26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s00101-015-0057-z","volume":"64","author":"RM Waeschle","year":"2015","unstructured":"Waeschle RM, Russo SG, Sliwa B et\u00a0al (2015) Perioperatives W\u00e4rmemanagement in Abh\u00e4ngigkeit von der Krankenhausgr\u00f6\u00dfe in Deutschland. Anaesthesist 64:612\u2013622","journal-title":"Anaesthesist"},{"key":"532_CR27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s00101-010-1773-z","volume":"59","author":"PK Zahn","year":"2010","unstructured":"Zahn PK, Sabatowski R, Schug SA et\u00a0al (2010) Paracetamol for perioperative analgesia. Old substance\u2014new insights. Anaesthesist 59:940\u2013952","journal-title":"Anaesthesist"},{"key":"532_CR28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1024\/1661-8157\/a001916","volume":"104","author":"E Zeiner","year":"2015","unstructured":"Zeiner E, Blaser LS, Tisljar K et al (2015) Fatale Agranulocytose nach Metamizol-Reexposition. Praxis (Bern 1994) 104:151\u2013154","journal-title":"Praxis (Bern 1994)"},{"key":"532_CR29","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ejpain.2005.09.002","volume":"10","author":"B Zernikow","year":"2006","unstructured":"Zernikow B, Smale H, Michel E et\u00a0al (2006) Paediatric cancer pain management using the WHO analgesic ladder\u2014results of a\u00a0prospective analysis from 2265 treatment days during a\u00a0quality improvement study. Eur J Pain 10:587\u2013595","journal-title":"Eur J Pain"}],"container-title":["Der Anaesthesist"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-018-0532-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00101-018-0532-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-018-0532-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T09:45:56Z","timestamp":1720950356000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00101-018-0532-4"}},"subtitle":["Ergebnisse einer Umfrage","Results of a survey"],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["532"],"URL":"https:\/\/doi.org\/10.1007\/s00101-018-0532-4","relation":{},"ISSN":["0003-2417","1432-055X"],"issn-type":[{"value":"0003-2417","type":"print"},{"value":"1432-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"assertion":[{"value":"25 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"L.\u00a0Witschi, L.\u00a0Reist, T.\u00a0Stammschulte, J.\u00a0Erlenwein, K.\u00a0Becke und U.\u00a0Stamer geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Dieser Beitrag beinhaltet keine von den Autoren durchgef\u00fchrten Studien an Menschen oder Tieren.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}