{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:00:11Z","timestamp":1785708011957,"version":"3.56.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesist"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund<\/jats:title><jats:p>Das MELAS-Syndrom ist gekennzeichnet durch Laktatazidose und schlaganfallartige Episoden. Es handelt sich um eine seltene, progredient verlaufende Erkrankung mit akuten neurologischen Episoden, die durch eine Mitochondriopathie ausgel\u00f6st wird. Durch einen Defekt der oxidativen Phosphorylierung in der Atmungskette kann es insbesondere in Stresssituationen zu einer inad\u00e4quaten Energiebereitstellung mit einer konsekutiven Laktatazidose kommen. Aufgrund der hohen Gefahr metabolischer Entgleisungen ist das MELAS-Syndrom im Hinblick auf das perioperative, an\u00e4sthesiologische Management eine gro\u00dfe Herausforderung.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ziel der Arbeit<\/jats:title><jats:p>Ziel dieser Arbeit soll es sein, einerseits einen allgemeinen \u00dcberblick \u00fcber die Besonderheiten des an\u00e4sthesiologischen Managements bei Patienten mit MELAS-Syndrom zu geben. Andererseits soll anhand eines Fallberichts dargestellt werden, wie eine intraoperative parenterale Ern\u00e4hrung m\u00f6glicherweise dazu beitragen kann, der Entstehung einer Laktatazidose entgegenzuwirken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material und Methoden<\/jats:title><jats:p>F\u00fcr diese Arbeit wurde eine systematische Literaturrecherche durchgef\u00fchrt. Da nur wenige Daten zum MELAS-Syndrom vorliegen, wurde zur Veranschaulichung au\u00dferdem ein Fallbericht in diese \u00dcbersichtsarbeit integriert.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse und Diskussion<\/jats:title><jats:p>Zusammenfassend kann gesagt werden, dass Patienten mit einem MELAS-Syndrom bez\u00fcglich des an\u00e4sthesiologischen Managements eine Herausforderung darstellen und ein engmaschiges Monitoring der Stoffwechsellage unabdingbar ist. Im Falle einer drohenden Laktatazidose k\u00f6nnte eine intraoperative parenterale Ern\u00e4hrung m\u00f6glicherweise ein neuer Therapieansatz sein, um die perioperative Versorgung dieser Patientengruppe in Zukunft zu verbessern.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00101-020-00793-8","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T11:02:40Z","timestamp":1589799760000},"page":"471-476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management von Patienten mit\u00a0MELAS-Syndrom","Management of patients with MELAS syndrome"],"prefix":"10.1007","volume":"69","author":[{"given":"Sebastian","family":"Roth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Nienhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Nickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Kindgen-Milles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kienbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar","family":"Huhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"793_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ymgme.2015.06.004","volume":"116","author":"W El-Hattab","year":"2015","unstructured":"El-Hattab\u00a0W, Adesina\u00a0AM, Jones\u00a0J et al (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. 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