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Die im Jahr 2020 erfolgte Fortschreibung der deutschen Leitlinie zur Behandlung des SE h\u00e4lt an der streng stufengerechten Therapie fest, die eskalierend die Anwendung von Benzodiazepinen, spezifischen Antiepileptika und An\u00e4sthetika vorsieht. Bisher ist die Eingrenzung eines in den allermeisten F\u00e4llen wirksamen sowie zugleich sicheren und interaktionsfreien Antiepileptikums nicht gelungen. Individuelle Vorerkrankungen und aktuelle Begleitumst\u00e4nde gehen daher genauso wie Erfahrungen des Behandlerteams in die differenzierte Behandlung des SE ein. Insbesondere bei therapierefrakt\u00e4ren Formen des SE erweist sich die Therapie als durchaus kompliziert und hat regelhaft intensivmedizinische Implikationen. Mithin ergeben sich im Zuge der modernen SE-Behandlung zahlreiche interdisziplin\u00e4re Schnittstellen. 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