{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:11:13Z","timestamp":1785453073136,"version":"3.56.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"S2","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesiologie"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00101-021-01040-4","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T20:02:11Z","timestamp":1632254531000},"page":"212-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of 5\u202f\u00b5g\/kg intrathecal morphine for postoperative analgesia in pediatric patients undergoing major surgery","Auswirkungen von 5\u00a0\u00b5g\/kg intrathekalem Morphin zur postoperativen Analgesie bei gr\u00f6\u00dferen Operationen p\u00e4diatrischer Patienten"],"prefix":"10.1007","volume":"71","author":[{"given":"G\u00fclsen","family":"Keskin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Ak\u0131n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye\u015fim","family":"\u015eenayl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can \u0130hsan","family":"\u00d6ztorun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Bah\u00e7ecitapar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"issue":"1","key":"1040_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1177\/000992289002900107","volume":"29","author":"JD Tobias","year":"1990","unstructured":"Tobias\u00a0JD, Deshpande\u00a0JK, Wetzel\u00a0RC et\u00a0al (1990) Postoperative analgesia. Use of intrathecal morphine in children. Clin Pediatr 29(1):44\u201348","journal-title":"Clin Pediatr"},{"key":"1040_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.urology.2016.04.064","volume":"97","author":"AK Srinivasan","year":"2016","unstructured":"Srinivasan\u00a0AK, Shrivastava\u00a0D, Kurzweil\u00a0RE et al (2016) Port site local anesthetic infiltration vs single-dose intrathecal opioid injection to control perioperative pain in children undergoing minimal invasive surgery: a comparative analysis. Urology 97:179\u2013183","journal-title":"Urology"},{"issue":"11","key":"1040_CR3","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/j.1460-9592.2009.03136.x","volume":"9","author":"S Apiliogullari","year":"2009","unstructured":"Apiliogullari\u00a0S, Duman\u00a0A, Gok\u00a0F et al (2009) Efficacy of a\u00a0low-dose spinal morphine with bupivacaine for postoperative analgesia in children undergoing hypospadias repair. Paediatr Anaesth 9(11):1078\u20131083","journal-title":"Paediatr Anaesth"},{"issue":"4","key":"1040_CR4","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1093\/bja\/aen025","volume":"100","author":"S Eschertzhuber","year":"2008","unstructured":"Eschertzhuber\u00a0S, Hohlrieder\u00a0M, Keller\u00a0C et al (2008) Comparison of high- and low-dose intrathecal morphine for spinal fusion in children. Br J Anaesth 100(4):538\u2013543","journal-title":"Br J Anaesth"},{"key":"1040_CR5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/bja\/56.2.137","volume":"56","author":"SE Jones","year":"1984","unstructured":"Jones\u00a0SE, Beasley\u00a0JM, MacFarlane\u00a0DW et\u00a0al (1984) Intrathecal morphine for postoperative pain relief in children. Br J Anaesth 56:137\u2013140","journal-title":"Br J Anaesth"},{"key":"1040_CR6","first-page":"1711","volume-title":"Miller\u2019s anesthesia","author":"RD Miller","year":"2015","unstructured":"Miller\u00a0RD, Eriksson\u00a0LI, Fleisher\u00a0LA et\u00a0al (2015) Miller\u2019s anesthesia, 8th\u00a0edn. Elsevier Saunders, Philadelphia, pp\u00a01711\u20131712 (Chapter 56)","edition":"8"},{"key":"1040_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1055\/s-0033-1351138","volume":"26","author":"V Garimella","year":"2013","unstructured":"Garimella\u00a0V, Cellini\u00a0C (2013) Postoperative pain control. Clin Colon Rectal Surg 26:191\u2013196","journal-title":"Clin Colon Rectal Surg"},{"issue":"3","key":"1040_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1093\/bjaceaccp\/mkn016","volume":"8","author":"A Hindle","year":"2008","unstructured":"Hindle\u00a0A (2008) Intrathecal opioids in the management of acute post operative pain. Cont Educ Anaesth Crit Care Pain 8(3):81\u201385","journal-title":"Cont Educ Anaesth Crit Care Pain"},{"issue":"1","key":"1040_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/pan.13037","volume":"27","author":"RA Hong","year":"2017","unstructured":"Hong\u00a0RA et\u00a0al (2017) A retrospective comparison of intrathecal morphine and epidural hydromorphone for analgesia following posterior spinal fusion in adolescents with idiopathic scoliosis. Paediatr Anaesth 27(1):91\u201397","journal-title":"Paediatr Anaesth"},{"key":"1040_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1460-9592.1995.tb00274.x","volume":"5","author":"WS Krechel","year":"1995","unstructured":"Krechel\u00a0WS, Helikson\u00a0MA, Kittle\u00a0D, Eggers\u00a0GWN (1995) Intrathecal morphin for postoperative pain in children: a comparison with nalbuphine for patient controlled analgesia. Paediatr Anaesth 5:177\u2013183","journal-title":"Paediatr Anaesth"},{"key":"1040_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1046\/j.1460-9592.1998.00737.x","volume":"8","author":"M Goodarzi","year":"1998","unstructured":"Goodarzi\u00a0M (1998) The advantages of intrathecal opioids for spinal fusion in children. Paediatr Anaesth 8:131\u2013134","journal-title":"Paediatr Anaesth"},{"key":"1040_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1213\/01.ane.0000252418.05394.28","volume":"104","author":"A Ganesh","year":"2007","unstructured":"Ganesh\u00a0A, Kim\u00a0A, Casale\u00a0P et al (2007) Low-dose intrathecal morphine for postoperative analgesia in children. Anesth Analg 104:271\u2013276","journal-title":"Anesth Analg"},{"key":"1040_CR13","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/j.0001-5172.2004.00449.x","volume":"48","author":"P Suominen","year":"2004","unstructured":"Suominen\u00a0P, Ragg\u00a0P, McKinley\u00a0D et\u00a0al (2004) Intrathecal morphine for postoperative analgesia in children following cardiac surgery. Acta Anaesthesiol Scand 48:875\u2013882","journal-title":"Acta Anaesthesiol Scand"},{"key":"1040_CR14","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1097\/00000542-200103000-00014","volume":"94","author":"O Gall","year":"2001","unstructured":"Gall\u00a0O, Aubineau\u00a0J\u2011V, Berniere\u00a0J et al (2001) Analgesic effect of low dose intrathecal morphine after spinal fusion in children. Anesthesiology 94:447\u2013452","journal-title":"Anesthesiology"},{"issue":"6","key":"1040_CR15","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1365-2044.2008.05817.x","volume":"64","author":"M Gehling","year":"2009","unstructured":"Gehling\u00a0M, Tryba\u00a0M (2009) Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a\u00a0meta-analysis. Anaesthesia 64(6):643\u2013651","journal-title":"Anaesthesia"},{"issue":"6","key":"1040_CR16","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/pan.13639","volume":"29","author":"JP Cravero","year":"2019","unstructured":"Cravero\u00a0JP, Agarwal\u00a0R, Berde\u00a0C et\u00a0al (2019) The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period. Paediatr Anaesth 29(6):547\u2013571","journal-title":"Paediatr Anaesth"},{"issue":"9","key":"1040_CR17","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/pan.12428","volume":"24","author":"N Bourdaud","year":"2014","unstructured":"Bourdaud\u00a0N, Devys\u00a0JM, Bientz\u00a0J et\u00a0al (2014) Development and validation of a\u00a0risk score to predict the probability of postoperative vomiting in pediatric patients: the VPOP score. Paediatr Anaesth 24(9):945\u2013952","journal-title":"Paediatr Anaesth"},{"issue":"6","key":"1040_CR18","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1097\/AJP.0000000000000706","volume":"35","author":"AS Berger","year":"2019","unstructured":"Berger\u00a0AS, Goldschneider\u00a0KR (2019) The role of neuraxial opioids in pediatric practice. Clin J Pain 35(6):497\u2013500","journal-title":"Clin J Pain"},{"key":"1040_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.anclin.2009.07.002","volume":"27","author":"WI Kremer","year":"2009","unstructured":"Kremer\u00a0WI, Rose\u00a0JB (2009) Pharmacologic management of acut pediatric pain. Anesthesiol Clin 27:241\u2013268","journal-title":"Anesthesiol Clin"},{"issue":"14","key":"1040_CR20","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2165\/11596250-000000000-00000","volume":"71","author":"P Sultan","year":"2011","unstructured":"Sultan\u00a0P, Gutierrez\u00a0MC, Carvalho\u00a0B (2011) Neuraxial morphine and respiratory depression: finding the right balance. Drugs 71(14):1807\u20131819","journal-title":"Drugs"},{"key":"1040_CR21","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1213\/ANE.0000000000002061","volume":"124","author":"M Cohen","year":"2017","unstructured":"Cohen\u00a0M, Zuk\u00a0J, McKay\u00a0N et al (2017) Intrathecal morphine versus extended-release epidural morphine for postoperative pain control in pediatric patients undergoing posterior spinal fusion. Anesth Analg 124:2030\u20132037","journal-title":"Anesth Analg"},{"key":"1040_CR22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1097\/BRS.0000000000002245","volume":"43","author":"Y Li","year":"2018","unstructured":"Li\u00a0Y, Hong\u00a0RA, Robbins\u00a0CB et\u00a0al (2018) Intrathecal morphine and oral analgesics provide safe and effective pain control after posterior spinal fusion for adolescent idiopathic scoliosis. Spine 43:98\u2013104","journal-title":"Spine"},{"key":"1040_CR23","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1097\/BRS.0b013e31817bd8be","volume":"33","author":"PA Tripi","year":"2008","unstructured":"Tripi\u00a0PA, Poe-Kochert\u00a0C, Potzman\u00a0J et al (2008) Intrathecal morphine for postoperative analgesia in patients with idiopathic scoliosis undergoing posterior spinal fusion. Spine 33:2248\u20132251","journal-title":"Spine"},{"key":"1040_CR24","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1213\/00000539-198307000-00004","volume":"62","author":"N Rawal","year":"1983","unstructured":"Rawal\u00a0N, Mollefors\u00a0K, Axelsson\u00a0K et\u00a0al (1983) An experimental study of urodynamic effects of epidural morphine and of naloxone reversal. Anesth Analg 62:641\u2013647","journal-title":"Anesth Analg"},{"issue":"3","key":"1040_CR25","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1054\/jpai.2002.123652","volume":"3","author":"M Wheeler","year":"2002","unstructured":"Wheeler\u00a0M, Oderda\u00a0GM, Ashburn\u00a0MA, Lipman\u00a0AG (2002) Adverse events associated with postoperative opioid analgesia: a\u00a0systematic review. J\u00a0Pain 3(3):159\u2013180","journal-title":"J Pain"}],"container-title":["Die Anaesthesiologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-021-01040-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00101-021-01040-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-021-01040-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T10:02:58Z","timestamp":1671444178000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00101-021-01040-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,21]]},"references-count":25,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["1040"],"URL":"https:\/\/doi.org\/10.1007\/s00101-021-01040-4","relation":{},"ISSN":["2731-6858","2731-6866"],"issn-type":[{"value":"2731-6858","type":"print"},{"value":"2731-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,21]]},"assertion":[{"value":"10 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"G.\u00a0Keskin, M.\u00a0Ak\u0131n, Y.\u00a0\u015eenayl\u0131, C.\u0130.\u00a0\u00d6ztorun and M.\u00a0Bah\u00e7ecitapar declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}