{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:55:01Z","timestamp":1773921301971,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesiologie"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Radial artery cannulation helps to maintain the stability of maternal hemodynamics and reduce complications; however, it is difficult for women with gestational hypertension. Subcutaneous nitroglycerin was found to improve the first attempt success rate of radial artery cannulation in pediatric patients. Therefore, this study evaluated the effect of subcutaneous nitroglycerin on the radial artery diameter and area, blood flow rate and the success rate of radial artery cannulation in women with pregnancy-induced hypertension.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A\u00a0total of 94 women with gestational hypertension and risk of intraoperative bleeding undergoing cesarean section were identified and randomized into the subcutaneous nitroglycerin group and control group. The primary outcome was the success rate of left radial artery cannulation within 3\u202fmin after subcutaneous injecting (T2). The puncture time, number of attempts, the overall complications, and ultrasonographic measurements including radial artery diameter, cross-sectional area and depth were also recorded before subcutaneous injection (T1), 3\u202fmin after subcutaneous injection (T2) and immediately after radial artery cannulation (T3).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The first attempt success rate of radial artery cannulation was significantly higher (97.9% vs. 76.6%, <jats:italic>p<\/jats:italic>\u202f=\u20090.004) and procedure time to success was significantly shorter (111\u202f\u00b1\u200918\u202fs vs. 171\u202f\u00b1\u200970\u202fs, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001) in the subcutaneous nitroglycerin group as compared to the control group. The subcutaneous nitroglycerin group also had a\u00a0significantly less overall number of attempts as 1\/2\/3 attempts (<jats:italic>n<\/jats:italic>), 46\/1\/0 vs. 36\/7\/4 (<jats:italic>p<\/jats:italic>\u202f=\u20090.008). Compared with the control group, the diameter and cross-sectional area of radial artery increased significantly at the T2 and T3\u00a0points in the subcutaneous nitroglycerin group (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001), as well as percentage change of radial artery diameter and CSA. Vasospasm (6.4% vs. 31.9%; <jats:italic>p<\/jats:italic>\u202f=\u20090.003) was significantly lower in the subcutaneous nitroglycerin group; however, no difference was found in hematoma (2.1% vs. 12.8%; <jats:italic>p<\/jats:italic>\u202f=\u20090.111).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Subcutaneous nitroglycerin along with the routine local anesthetic preparation before radial artery cannulation increased the first attempt success rate of radial artery cannulation and decreased the overall number of cannulation attempts in women with gestational hypertension and risks of intraoperative bleeding undergoing cesarean section, it also decreased cannulation times and overall number of vasospasms.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00101-023-01264-6","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T20:26:39Z","timestamp":1679862399000},"page":"28-35","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Subcutaneous nitroglycerin increased the success rate of radial artery cannulation in women with gestational hypertension undergoing cesarean section","Subkutanes Nitroglyzerin erh\u00f6hte die Erfolgsrate der Kan\u00fclierung der A.\u00a0radialis bei Frauen mit Schwangerschaftshypertonie, die sich einem Kaiserschnitt unterziehen"],"prefix":"10.1007","volume":"72","author":[{"given":"Xin","family":"Men","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-sheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-yan","family":"Shou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"issue":"3","key":"1264_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/ACO.0000000000000835","volume":"33","author":"R Russell","year":"2020","unstructured":"Russell\u00a0R (2020) Preeclampsia and the anaesthesiologist: current management. Curr Opin Anaesthesiol 33(3):305\u2013310","journal-title":"Curr Opin Anaesthesiol"},{"issue":"9995","key":"1264_CR2","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/S0140-6736(15)60692-4","volume":"386","author":"Global Burden of Disease Study 2013 Collaborators","year":"2015","unstructured":"Global Burden of Disease Study 2013 Collaborators (2015) Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188\u00a0countries, 1990\u20132013: a\u00a0systematic analysis for the Global Burden of Disease Study 2013. Lancet 386(9995):743\u2013800","journal-title":"Lancet"},{"issue":"3","key":"1264_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/ALN.0000000000001774","volume":"127","author":"EH Kim","year":"2017","unstructured":"Kim\u00a0EH, Lee\u00a0JH, Song\u00a0IK, Kim\u00a0JT, Lee\u00a0WJ, Kim\u00a0HS (2017) Posterior tibial artery as an alternative to the radial artery for arterial cannulation site in small children: a randomized controlled study. Anesthesiology 127(3):423\u2013431","journal-title":"Anesthesiology"},{"issue":"6","key":"1264_CR4","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1213\/ANE.0b013e3181bbd416","volume":"109","author":"M Brzezinski","year":"2009","unstructured":"Brzezinski\u00a0M, Luisetti\u00a0T, London\u00a0MJ (2009) Radial artery cannulation: a\u00a0comprehensive review of recent anatomic and physiologic investigations. Anesth Analg 109(6):1763\u20131781","journal-title":"Anesth Analg"},{"issue":"7","key":"1264_CR5","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1097\/EJA.0000000000000453","volume":"33","author":"IK Song","year":"2016","unstructured":"Song\u00a0IK, Choi\u00a0JY, Lee\u00a0JH et al (2016) Short-axis\/out-of-plane or long-axis\/in-plane ultrasound-guided arterial cannulation in children: a randomised controlled trial. Eur J Anaesthesiol 33(7):522\u2013527","journal-title":"Eur J Anaesthesiol"},{"issue":"5","key":"1264_CR6","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/PCC.0b013e31828a8657","volume":"14","author":"S Ishii","year":"2013","unstructured":"Ishii\u00a0S, Shime\u00a0N, Shibasaki\u00a0M, Sawa\u00a0T (2013) Ultrasound-guided radial artery catheterization in infants and small children. Pediatr Crit Care Med 14(5):471\u2013473","journal-title":"Pediatr Crit Care Med"},{"issue":"6","key":"1264_CR7","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1017\/S0265021506000275","volume":"23","author":"U Schwemmer","year":"2006","unstructured":"Schwemmer\u00a0U, Arzet\u00a0HA, Trautner\u00a0H, Rauch\u00a0S, Roewer\u00a0N, Greim\u00a0CA (2006) Ultrasound-guided arterial cannulation in infants improves success rate. Eur J Anaesthesiol 23(6):476\u2013480","journal-title":"Eur J Anaesthesiol"},{"issue":"1","key":"1264_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1213\/ANE.0000000000002261","volume":"126","author":"RK Kiberenge","year":"2018","unstructured":"Kiberenge\u00a0RK, Ueda\u00a0K, Rosauer\u00a0B (2018) Ultrasound-guided dynamic needle tip positioning technique versus palpation technique for radial arterial cannulation in adult surgical patients: a randomized controlled trial. Anesth Analg 126(1):120\u2013126","journal-title":"Anesth Analg"},{"issue":"1","key":"1264_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12871-021-01244-6","volume":"21","author":"N Kim","year":"2021","unstructured":"Kim\u00a0N, Kim\u00a0HI, Kim\u00a0DH, Park\u00a0D, Song\u00a0SH, Byon\u00a0HJ (2021) A novel electromagnetic guidance ultrasound system on radial artery cannulation: a\u00a0prospective randomized controlled trial. BMC Anesthesiol 21(1):21","journal-title":"BMC Anesthesiol"},{"issue":"5","key":"1264_CR10","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1093\/bja\/aew097","volume":"116","author":"L White","year":"2016","unstructured":"White\u00a0L, Halpin\u00a0A, Turner\u00a0M, Wallace\u00a0L (2016) Ultrasound-guided radial artery cannulation in adult and paediatric populations: a\u00a0systematic review and meta-analysis. Br J Anaesth 116(5):610\u2013617","journal-title":"Br J Anaesth"},{"issue":"5","key":"1264_CR11","first-page":"505","volume":"99","author":"S Tangwiwat","year":"2016","unstructured":"Tangwiwat\u00a0S, Pankla\u00a0W, Rushatamukayanunt\u00a0P, Waitayawinyu\u00a0P, Soontrakom\u00a0T, Jirakulsawat\u00a0A (2016) Comparing the success rate of radial artery cannulation under ultrasound guidance and palpation technique in adults. J\u00a0Med Assoc Thai 99(5):505\u2013510","journal-title":"J Med Assoc Thai"},{"issue":"9","key":"1264_CR12","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/anae.13062","volume":"70","author":"K Ueda","year":"2015","unstructured":"Ueda\u00a0K, Bayman\u00a0EO, Johnson\u00a0C, Odum\u00a0NJ, Lee\u00a0JJ (2015) A randomised controlled trial of radial artery cannulation guided by Doppler vs. palpation vs. ultrasound. Anaesthesia 70(9):1039\u20131044","journal-title":"Anaesthesia"},{"issue":"3","key":"1264_CR13","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1016\/j.ijcard.2013.03.048","volume":"168","author":"AT Beyer","year":"2013","unstructured":"Beyer\u00a0AT, Ng\u00a0R, Singh\u00a0A et al (2013) Topical nitroglycerin and lidocaine to dilate the radial artery prior to transradial cardiac catheterization: a\u00a0randomized, placebo-controlled, double-blind clinical trial: the PRE-DILATE Study. Int J Cardiol 168(3):2575\u20132578","journal-title":"Int J Cardiol"},{"issue":"5","key":"1264_CR14","doi-asserted-by":"publisher","first-page":"532.e9","DOI":"10.1016\/j.jcrc.2012.04.019","volume":"27","author":"DT Majure","year":"2012","unstructured":"Majure\u00a0DT, Hallaux\u00a0M, Yeghiazarians\u00a0Y, Boyle\u00a0AJ (2012) Topical nitroglycerin and lidocaine locally vasodilate the radial artery without affecting systemic blood pressure: a\u00a0dose-finding phase I study. J\u00a0Crit Care 27(5):532.e9\u2013532.13","journal-title":"J Crit Care"},{"issue":"1","key":"1264_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/ALN.0000000000003308","volume":"133","author":"YE Jang","year":"2020","unstructured":"Jang\u00a0YE, Ji\u00a0SH, Kim\u00a0EH et\u00a0al (2020) Subcutaneous nitroglycerin for radial arterial catheterization in pediatric patients: a randomized controlled trial. Anesthesiology 133(1):53\u201363","journal-title":"Anesthesiology"},{"issue":"5","key":"1264_CR16","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/pan.12151","volume":"23","author":"EQ Varga","year":"2013","unstructured":"Varga\u00a0EQ, Candiotti\u00a0KA, Saltzman\u00a0B et al (2013) Evaluation of distal radial artery cross-sectional internal diameter in pediatric patients using ultrasound. Paediatr Anaesth 23(5):460\u2013462","journal-title":"Paediatr Anaesth"},{"key":"1264_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2147\/LRA.S9524","volume":"3","author":"JJ Badal","year":"2010","unstructured":"Badal\u00a0JJ, Kiesau\u00a0A, Boyle\u00a0P (2010) Effects of median nerve block on radial artery diameter and peak velocity. Local Reg Anesth 3:5\u201310","journal-title":"Local Reg Anesth"},{"issue":"2","key":"1264_CR18","doi-asserted-by":"publisher","first-page":"100831","DOI":"10.1016\/j.accpm.2021.100831","volume":"40","author":"C Sinha","year":"2021","unstructured":"Sinha\u00a0C, Kumar\u00a0A, Kumari\u00a0P, Kumar\u00a0A, Bhar\u00a0D, Singh\u00a0V (2021) Does radial or median nerve blocks affect the area and blood flow of radial artery. Anaesth Crit Care Pain Med 40(2):100831","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"1","key":"1264_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1213\/ANE.0000000000000242","volume":"119","author":"Z Quan","year":"2014","unstructured":"Quan\u00a0Z, Tian\u00a0M, Chi\u00a0P, Cao\u00a0Y, Li\u00a0X, Peng\u00a0K (2014) Modified short-axis out-of-plane ultrasound versus conventional long-axis in-plane ultrasound to guide radial artery cannulation: a\u00a0randomized controlled trial. Anesth Analg 119(1):163\u2013169","journal-title":"Anesth Analg"},{"issue":"3","key":"1264_CR20","first-page":"431","volume":"41","author":"G Goh","year":"2013","unstructured":"Goh\u00a0G, Tan\u00a0C, Weinberg\u00a0L (2013) Dynamic ultrasound-guided, short axis, out-of-plane radial artery cannulation: the \u2018follow the tip\u2019 technique. Anaesth Intensive Care 41(3):431\u2013432","journal-title":"Anaesth Intensive Care"},{"issue":"3","key":"1264_CR21","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.carrev.2011.11.003","volume":"13","author":"HH Ho","year":"2012","unstructured":"Ho\u00a0HH, Jafary\u00a0FH, Ong\u00a0PJ (2012) Radial artery spasm during transradial cardiac catheterization and percutaneous coronary intervention: incidence, predisposing factors, prevention, and management. Cardiovasc Revasc Med 13(3):193\u2013195","journal-title":"Cardiovasc Revasc Med"},{"issue":"4","key":"1264_CR22","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1399-6576.2006.01260.x","volume":"51","author":"V Yildirim","year":"2007","unstructured":"Yildirim\u00a0V, Akay\u00a0HT, Bingol\u00a0H et al (2007) Pre-emptive stellate ganglion block increases the patency of radial artery grafts in coronary artery bypass surgery. Acta Anaesthesiol Scand 51(4):434\u2013440","journal-title":"Acta Anaesthesiol Scand"},{"issue":"4","key":"1264_CR23","first-page":"155","volume":"18","author":"J Coppola","year":"2006","unstructured":"Coppola\u00a0J, Patel\u00a0T, Kwan\u00a0T et\u00a0al (2006) Nitroglycerin, nitroprusside, or both, in preventing radial artery spasm during transradial artery catheterization. J\u00a0Invasive Cardiol 18(4):155\u2013158","journal-title":"J Invasive Cardiol"},{"issue":"2","key":"1264_CR24","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/1053-0770(94)90091-4","volume":"8","author":"Y Mehta","year":"1994","unstructured":"Mehta\u00a0Y, Juneja\u00a0R (1994) Continuous axillary block for ischemia following failed radial artery cannulation. J\u00a0Cardiothorac Vasc Anesth 8(2):257","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"3","key":"1264_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/cc1489","volume":"6","author":"B Scheer","year":"2002","unstructured":"Scheer\u00a0B, Perel\u00a0A, Pfeiffer\u00a0UJ (2002) Clinical review: complications and risk factors of peripheral arterial catheters used for haemodynamic monitoring in anaesthesia and intensive care medicine. Crit Care 6(3):199\u2013204","journal-title":"Crit Care"},{"issue":"5","key":"1264_CR26","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1002\/ccd.25661","volume":"85","author":"S Dharma","year":"2015","unstructured":"Dharma\u00a0S, Kedev\u00a0S, Patel\u00a0T, Kiemeneij\u00a0F, Gilchrist\u00a0IC (2015) A novel approach to reduce radial artery occlusion after transradial catheterization: postprocedural\/prehemostasis intra-arterial nitroglycerin. Catheter Cardiovasc Interv 85(5):818\u2013825","journal-title":"Catheter Cardiovasc Interv"},{"issue":"6","key":"1264_CR27","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.ihj.2014.05.023","volume":"66","author":"B Ezhumalai","year":"2014","unstructured":"Ezhumalai\u00a0B, Satheesh\u00a0S, Jayaraman\u00a0B (2014) Effects of subcutaneously infiltrated nitroglycerin on diameter, palpability, ease-of-puncture and pre-cannulation spasm of radial artery during transradial coronary angiography. Indian Heart\u00a0J 66(6):593\u2013597","journal-title":"Indian Heart J"},{"issue":"1","key":"1264_CR28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/00000542-200401000-00023","volume":"100","author":"SK Sharma","year":"2004","unstructured":"Sharma\u00a0SK, McIntire\u00a0DD, Wiley\u00a0J, Leveno\u00a0KJ (2004) Labor analgesia and cesarean delivery: an individual patient meta-analysis of nulliparous women. Anesthesiology 100(1):142\u2013148 (discussion 6A)","journal-title":"Anesthesiology"},{"issue":"5","key":"1264_CR29","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/S0022-5223(98)70414-3","volume":"115","author":"GW He","year":"1998","unstructured":"He\u00a0GW, Yang\u00a0CQ (1998) Characteristics of adrenoceptors in the human radial artery: clinical implications. J\u00a0Thorac Cardiovasc Surg 115(5):1136\u20131141","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"1264_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/(SICI)1522-726X(200003)49:3<253::AID-CCD5>3.0.CO;2-5","volume":"49","author":"S Abe","year":"2000","unstructured":"Abe\u00a0S, Meguro\u00a0T, Endoh\u00a0N et\u00a0al (2000) Response of the radial artery to three vasodilatory agents. Catheter Cardiovasc Interv 49(3):253\u2013256","journal-title":"Catheter Cardiovasc Interv"},{"issue":"19 Suppl","key":"1264_CR31","first-page":"II322","volume":"100","author":"OM Shapira","year":"1999","unstructured":"Shapira\u00a0OM, Xu\u00a0A, Aldea\u00a0GS, Vita\u00a0JA, Shemin\u00a0RJ, Keaney\u00a0JF Jr. (1999) Enhanced nitric oxide-mediated vascular relaxation in radial artery compared with internal mammary artery or saphenous vein. Circulation 100(19 Suppl):II322\u2013II327","journal-title":"Circulation"},{"issue":"6","key":"1264_CR32","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1213\/00000539-197511000-00048","volume":"54","author":"JM Kim","year":"1975","unstructured":"Kim\u00a0JM, Arakawa\u00a0K, Bliss\u00a0J (1975) Arterial cannulation: factors in the development of occlusion. Anesth Analg 54(6):836\u2013841","journal-title":"Anesth Analg"},{"issue":"5","key":"1264_CR33","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1213\/ANE.0000000000000164","volume":"118","author":"Y Nakayama","year":"2014","unstructured":"Nakayama\u00a0Y, Nakajima\u00a0Y, Sessler\u00a0DI et al (2014) A novel method for ultrasound-guided radial arterial catheterization in pediatric patients. Anesth Analg 118(5):1019\u20131026","journal-title":"Anesth Analg"},{"issue":"7","key":"1264_CR34","doi-asserted-by":"publisher","first-page":"e006571","DOI":"10.1161\/CIRCINTERVENTIONS.118.006571","volume":"11","author":"Y Chen","year":"2018","unstructured":"Chen\u00a0Y, Ke\u00a0Z, Xiao\u00a0J et al (2018) Subcutaneous injection of nitroglycerin at the radial artery puncture site reduces the risk of early radial artery occlusion after transradial coronary Catheterization: a randomized, placebo-controlled clinical trial. Circ Cardiovasc Interv 11(7):e6571","journal-title":"Circ Cardiovasc Interv"},{"issue":"3","key":"1264_CR35","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/ccd.20881","volume":"68","author":"SB Pancholy","year":"2006","unstructured":"Pancholy\u00a0SB, Coppola\u00a0J, Patel\u00a0T (2006) Subcutaneous administration of nitroglycerin to facilitate radial artery cannulation. Catheter Cardiovasc Interv 68(3):389\u2013391","journal-title":"Catheter Cardiovasc Interv"},{"issue":"19","key":"1264_CR36","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1161\/01.CIR.0000036743.07406.53","volume":"106","author":"T Gori","year":"2002","unstructured":"Gori\u00a0T, Parker\u00a0JD (2002) Nitrate tolerance: a\u00a0unifying hypothesis. Circulation 106(19):2510\u20132513","journal-title":"Circulation"}],"container-title":["Die Anaesthesiologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-023-01264-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00101-023-01264-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-023-01264-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T12:03:16Z","timestamp":1701432196000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00101-023-01264-6"}},"subtitle":["A\u00a0randomized controlled trial","Eine randomisierte kontrollierte Studie"],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":36,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["1264"],"URL":"https:\/\/doi.org\/10.1007\/s00101-023-01264-6","relation":{},"ISSN":["2731-6858","2731-6866"],"issn-type":[{"value":"2731-6858","type":"print"},{"value":"2731-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"22 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"X.\u00a0Men,Q.\u00a0Wang, P.\u00a0Chen, W.\u2011s.\u00a0Hu, Y.\u00a0Chai, H.\u2011y.\u00a0Shou and Z.\u2011f.\u00a0Zhou declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by The Ethics Committee of Hangzhou Women\u2019s Hospital (IRB:2021-K(9)-02) and written informed consent was obtained from all subjects participating in the study. All methods were performed in accordance with the relevant guidelines and regulations. Clinical trial number and registry URL: ChiCTR2100052981;, Principal investigator: Xin Men, date of registration: 7\u00a0November2021.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The supplement containing this article is not sponsored by industry.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}