{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:43:27Z","timestamp":1771490607776,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008967","name":"Philipps-Universit\u00e4t Marburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008967","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesiologie"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>W\u00e4hrend zu klinischer \u00dcberwachung und Kontrolle von Hypnose und Muskelrelaxation validierte Methoden im An\u00e4sthesiealltag existieren, basiert die Einsch\u00e4tzung der Analgesie immer noch \u00fcberwiegend auf der Interpretation klinischer Vitalparameter. In der vorliegenden klinischen Studie wurde untersucht, ob die Verwendung eines \u201eNozizeption-Monitors\u201c zur Erfassung des intraoperativen Analgetikabedarfs der bisherigen Analyse der Vitalparameter \u00fcberlegen ist. Zur quantitativen Erfassung der Analgesie wurde der Analgesia Nociception Index (ANI; Fa. MDoloris, Lille, France) verwendet. Dieser beruht auf der Analyse der atemabh\u00e4ngigen Herzfrequenzvariabilit\u00e4t.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methode<\/jats:title>\n                <jats:p>Es handelt sich um eine klinische prospektive randomisierte kontrollierte Einfachblindstudie an 110\u00a0Patientinnen, welche sich einer laparoskopischen Hysterektomie in balancierter An\u00e4sthesie in der Agaplesion Diakonie Kliniken Kassel unterzogen.<\/jats:p>\n                <jats:p>Bei der Interventionsgruppe (ANI) erfolgte die intraoperative Analgetikagabe unter Verwendung des ANI-Monitors, wohingegen in der Vergleichsgruppe (VER) die Analgetikadosierung nach bisherigen klinischen Parametern (Vitalparameter, intraoperative Abwehrbewegungen) erfolgte. Anschlie\u00dfend wurden die Gruppen im Hinblick auf intraoperativen Opioidverbrauch (Fentanyl), postoperative Schmerzen und opioidinduzierte Nebenwirkungen sowie Patientenzufriedenheit am 3.\u00a0postoperativen Tag verglichen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Insgesamt wurden 101\u00a0Patientinnen analysiert. Unsere Beobachtungen ergaben einen h\u00f6heren durchschnittlichen intraoperativen Fentanylverbrauch in der Interventionsgruppe, bedingt durch eine signifikant h\u00f6here Anzahl an Einzelgaben (0,54 vs. 0,44\u202fmg, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090,001). Bez\u00fcglich der weiteren Beobachtungspunkte gab es kaum Unterschiede zwischen den Gruppen. Bei der Patientenbefragung am 3.\u00a0postoperativen Tag ergab sich ein Unterschied bez\u00fcglich einer h\u00f6heren subjektiv geschilderten Vigilanzminderung in der ANI-Gruppe, nicht jedoch anderer Nebenwirkungen oder der Zufriedenheit mit der Schmerztherapie insgesamt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Eine Optimierung der Schmerztherapie durch intraoperative Zuhilfenahme des Analgesia-Nociception-Index(ANI)-Monitors bei Hysterektomiepatientinnen unter balancierter An\u00e4sthesie mit Sevofluran und Fentanyl konnte demzufolge nicht nachgewiesen werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00101-023-01288-y","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T13:02:27Z","timestamp":1686142947000},"page":"477-487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intraoperative Analgesiesteuerung: Analgesie Nociception Index (ANI) vs. \u201estandard care\u201c bei Hysterektomien unter Sevoflurannarkose","Intraoperative guidance of anesthesia: Analgesie Nociception Index (ANI) vs. standard care for hysterectomy under anesthesia with sevoflurane"],"prefix":"10.1007","volume":"72","author":[{"given":"A. M.","family":"Kunst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Stegemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fiehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"1288_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2019.03.002","author":"R Abdullayev","year":"2019","unstructured":"Abdullayev R et al (2019) Analgesia Nociception Index: assessment of acute postoperative pain. Rev Bras Anestesiol. https:\/\/doi.org\/10.1016\/j.bjane.2019.03.002","journal-title":"Rev Bras Anestesiol"},{"key":"1288_CR2","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1111\/pme.12751","volume":"16","author":"A Buvanendran","year":"2015","unstructured":"Buvanendran A, Fiala J, Patel KA, Golden AD, Moric M, Kroin JS (2015) The incidence and severity of postoperative pain following inpatient surgery. Pain Med 16:2277\u20132283","journal-title":"Pain Med"},{"key":"1288_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2016.08.006","author":"G Daccache","year":"2016","unstructured":"Daccache G et al (2016) A targetet remifentanil administration protocol based on the Analgesia Nociception Index during vascular sugery. Anaesth Crit Care Pain Med. https:\/\/doi.org\/10.1016\/j.accpm.2016.08.006","journal-title":"Anaesth Crit Care Pain Med"},{"key":"1288_CR4","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002145","author":"G Daccache","year":"2017","unstructured":"Daccache G, Jeanne M, Fletcher D (2017) The Analgesia Nociception Index: Tailoring Opioid Administration. Int Anaesth Res Soc. https:\/\/doi.org\/10.1213\/ANE.0000000000002145","journal-title":"Soc"},{"key":"1288_CR5","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1093\/bja\/aet485","volume":"112","author":"M Gruenewald","year":"2014","unstructured":"Gruenewald M, Willms\u00a0S, Brach\u00a0O, Kott\u00a0M, Steinfath\u00a0M, Bein\u00a0B (2014) Sufentanil administration guided by surgical Plethi Index vs standard practice during sevoflurane anaesthesia: a\u00a0randomized controlled pilot study. Br J Anaesth 112:898\u2013905","journal-title":"Br J Anaesth"},{"key":"1288_CR6","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1097\/AJP.0000000000000083","volume":"30","author":"M Jeanne","year":"2014","unstructured":"Jeanne M, Delecroix M, De Jonckheere J, Keribedj A, Logier R, Tavernier B  (2014) Variations of the Analgesia Nociception Index during Propofol anesthesia for total knee replacement. Clin J Pain 30:1084\u20131088. https:\/\/doi.org\/10.1097\/AJP.0000000000000083","journal-title":"Clin J Pain"},{"key":"1288_CR7","doi-asserted-by":"crossref","unstructured":"Jeanne M, Logier R, De Jonckheere J, Tavernier B (2009) Validation of a\u00a0graphic measurement of heart rate variability to assess analgesia\/nociception balance during general anesthesia. In International Conference of the IEEE EMBS, 2009","DOI":"10.1109\/IEMBS.2009.5332598"},{"key":"1288_CR8","first-page":"63","volume":"2","author":"M Jeanne","year":"2017","unstructured":"Jeanne M, Tavernier B, Logier R, De Jonckheere J (2017) Closed-loop administration of general anaesthesia: from sensor to medical device. Pharm Technol Hosp Pharm 2:63\u201370","journal-title":"Hosp Pharm"},{"key":"1288_CR9","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.bja.2019.03.024","volume":"123","author":"T Ledowski","year":"2019","unstructured":"Ledowski\u00a0T (2019) Objective monitoring of nociception: a\u00a0review of current commercial solutions. Br Jornal Anesth Pp 123:312\u2013321","journal-title":"Br Jornal Anesth Pp"},{"key":"1288_CR10","first-page":"35","volume":"38","author":"L Le Gall","year":"2017","unstructured":"Le Gall\u00a0L, David\u00a0A, Carles\u00a0P, Leuillet\u00a0S, Chastel\u00a0B, Fleureau\u00a0C, Dewitte\u00a0A, Ouattara\u00a0A (2017) Benefits of intraoperative analgesia guided by the Analgesia Nociception Index (ANI) in bariatric surgery: an unmatched case-control study. SFAR 38:35\u201339","journal-title":"SFAR"},{"key":"1288_CR11","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s00101-021-01022-6","volume":"70","author":"R Nitzschke","year":"2021","unstructured":"Nitzschke\u00a0R, Fischer\u00a0M, Funcke\u00a0S (2021) Nozizeptionsmonitoring \u2013 Methode zur intraoperativen Opioidsteuerung? Anaesthesist 70:735\u2013752","journal-title":"Anaesthesist"},{"key":"1288_CR12","unstructured":"qm-anaesthesie.de https:\/\/www.qm-anaesthesie.de\/fachmaterial\/downloads\/ppp33-fragebogen\/10-ppp33-fragebogen-version-050415-dina3\/file.html. Zugegriffen: 1. Aug. 2019"},{"issue":"4","key":"1288_CR13","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1093\/bja\/aeu411","volume":"114","author":"J Szental","year":"2015","unstructured":"Szental J, Webb A, Weeraratne C, Campbell A, Sivakumar H, Leong S (2015) Postoperative pain after laparoscopic cholecystectomy is not reduced by intraoperative analgesia guided by Analgesia Nociception Index (ANI) monitoring: a randomized clinical trial. Brit J Anaesthes 114(4):640\u2013645. https:\/\/doi.org\/10.1093\/bja\/aeu411","journal-title":"Brit J Anaesthes"},{"key":"1288_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1213\/ANE.0000000000001984","volume":"125","author":"H Upton","year":"2017","unstructured":"Upton\u00a0H, Ludbrook\u00a0G, Wing\u00a0A, Sleigh\u00a0J (2017) \u201eintraoperative \u201eAnalgesia Nociception Index\u201c\u2014guided fentanyl administration during sevoflurane an\u00e4sthesie in lumbar discectomy and laminectomy: a randomized clinical trial. Anesth Analg 125:81\u201390","journal-title":"Anesth Analg"},{"key":"1288_CR15","doi-asserted-by":"publisher","first-page":"4386","DOI":"10.1177\/0300060518796749","volume":"46","author":"Y Won","year":"2018","unstructured":"Won\u00a0Y, Kim\u00a0Y, Lee\u00a0M, Kim\u00a0H (2018) Usefulness of surgical pleats index\u2014guided analgesia during general anesthesia: a\u00a0systematic review and meta-analysis of randomized controlled trials. J\u00a0Int Med Res 46:4386\u20134398","journal-title":"J Int Med Res"}],"container-title":["Die Anaesthesiologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-023-01288-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00101-023-01288-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-023-01288-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T12:03:05Z","timestamp":1688558585000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00101-023-01288-y"}},"subtitle":["Eine randomisierte kontrollierte Einfachblindstudie zu intraoperativem Opioidverbrauch, postoperativen Schmerzen und Patientenzufriedenheit","A randomized controlled simple blinded study on intraoperative opioid consumption, postoperative pain and patient satisfaction"],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["1288"],"URL":"https:\/\/doi.org\/10.1007\/s00101-023-01288-y","relation":{},"ISSN":["2731-6858","2731-6866"],"issn-type":[{"value":"2731-6858","type":"print"},{"value":"2731-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"15 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"A.M.\u00a0Kunst, H.\u00a0Wulf, B.\u00a0Stegemann und A.\u00a0Fiehn geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patient\/-innen liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}