{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:11:59Z","timestamp":1783037519486,"version":"3.54.6"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesiologie"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:sec>\n            <jats:title>Hintergrund<\/jats:title>\n            <jats:p>Im September 2023 wurde die \u00fcberarbeitete S3-Leitlinie <jats:italic>Versorgung peripherer Nervenverletzungen <\/jats:italic>publiziert. Multimodale schmerztherapeutische Behandlungsstrategien haben hierbei Eingang in die Leitlinie gefunden und schlie\u00dfen systemische und lokal-medikament\u00f6se, physiotherapeutische und ergotherapeutische Ma\u00dfnahmen mit ein. Eine zentrale Fragestellung bewertete dabei die viel diskutierte Behandlungsoption mittels perineuraler Lokalan\u00e4sthesie.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ziel der Arbeit<\/jats:title>\n            <jats:p>Um die Effektivit\u00e4t lokaler Infiltrationen bei der Behandlung von neuropathischen Schmerzen nach einer Nervenverletzung darzustellen, erfolgen eine systematische Literaturrecherche und Evidenzbewertung mittels Metaanalyse.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Material und Methoden<\/jats:title>\n            <jats:p>Nach Formulierung einer entsprechenden PICO(\u201epatient\/population, intervention, comparison and outcomes\u201c)-Frage (Infobox\u00a01) innerhalb der Leitliniengruppe erfolgte eine selektive Literaturanalyse zu klinischen Studien in Datenbanken (PubMed, Cochrane Central Register of Controlled Trials \u2013 CENTRAL) bis zum 31.07.2023. Zwei Reviewer bewerteten die Literatur und pr\u00fcften systematische Reviews auf zus\u00e4tzliche Literaturverweise.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Insgesamt wurden 357 Publikationen identifiziert. Nach Entfernung von Duplikaten (<jats:italic>n<\/jats:italic>\u202f=\u200915) wurden <jats:italic>n<\/jats:italic>\u202f=\u2009327 Publikationen bewertet. In der vertiefenden Literaturanalyse wurde schlussendlich eine relevante Studie identifiziert und in die Evidenzbewertung eingeschlossen.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Diskussion<\/jats:title>\n            <jats:p>Lokalan\u00e4sthetikainfiltrationen stellen eine Therapieoption von Neuropathien nach Amputationen dar. Ein RCT (Randomisierte kontrollierte Studie) zeigte \u00fcber 4\u00a0Wochen nach mehrt\u00e4giger perineuraler Lokalan\u00e4sthetikainfiltration eine Reduktion von Schmerzen und schmerzbedingter Funktionseinschr\u00e4nkung. Weitere Studien sind erforderlich, um einen h\u00f6heren Evidenzgrad zur Effektivit\u00e4t dieser Therapieform ableiten zu k\u00f6nnen.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphic abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00101-025-01500-1","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T12:23:07Z","timestamp":1740399787000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systematisches Review zur Effektivit\u00e4t von Lokalan\u00e4sthetika bei der Therapie von neuropathischen Schmerzen oder Phantomschmerzen","Systematic review of the effectiveness of local anaesthetics in the treatment of neuropathic pain or phantom pain"],"prefix":"10.1007","volume":"74","author":[{"given":"Joanna","family":"Kastelik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Schwerdtfeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Stolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Tafelski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"1500_CR1","first-page":"512","volume":"46","author":"Anonymous","year":"1892","unstructured":"Anonymous (1892) Treatment of Neuralgia by Hypodermic Injections of. 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Unabh\u00e4ngig von der vorliegenden Arbeit ist S.\u00a0Tafelski t\u00e4tig im Wissenschaftlichen Arbeitskreis Schmerzmedizin der DGAI e.\u202fV. sowie in der Deutschen Schmerzgesellschaft e.\u202fV.. Er erhielt DFG-F\u00f6rderung \u00fcber den Open Access Publication Fonds der Charit\u00e9\u00a0\u2013 Universit\u00e4tsmedizin Berlin und institutionelle F\u00f6rderung \u00fcber die AMS Stiftung. K.\u00a0Schwerdtfeger ist Teil folgender medizinischer Gesellschaften DGNKN, DGNC, DGKN, GMDS.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor:innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}