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Welche Toxine zu schweren und letalen Vergiftungen f\u00fchren, wurde in Deutschland bislang nicht genau analysiert.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methode<\/jats:title>\n            <jats:p>In dieser Untersuchung wurden alle \u00fcber einen 5\u2011Jahres-Zeitraum vom Rettungsdienst dem GIZ-Nord gemeldeten Vergiftungen, die einen schweren oder t\u00f6dlichen Verlauf hatten, analysiert. Die Vergiftungsschwere wurde mittels Poisoning Severity Score (PSS) [4] klassifiziert, und die urs\u00e4chlichen Noxen wurden nach dem ATC-System [6] zugeordnet.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Ergebnisse<\/jats:title>\n            <jats:p>Von 8528 Anfragen waren in 259 F\u00e4llen die Intoxikationen schwer, in 14\u00a0F\u00e4llen letal. Am h\u00e4ufigsten betroffen waren 20- bis 49-J\u00e4hrige. In 221 (81\u202f%) dieser F\u00e4lle erfolgte die Intoxikation in suizidaler Absicht und am h\u00e4ufigsten im h\u00e4uslichen Umfeld. In 199 F\u00e4llen waren Arzneimittel, die mehrheitlich von Frauen (60,8\u202f%) eingenommen wurden, urs\u00e4chlich. Die h\u00e4ufigsten Substanzen waren Medikamente mit Wirkungen auf das Nervensystem, am zweith\u00e4ufigsten, aber nur in 16\u00a0F\u00e4llen, Medikamente mit Wirkung auf das kardiovaskul\u00e4re System. In 29\u00a0F\u00e4llen (10,6\u202f%) waren chemische Produkte ausl\u00f6sendes Agens, und nur bei 14\u00a0F\u00e4llen (5,1\u202f%) waren es Drogen. T\u00f6dliche Verl\u00e4ufe wurden bei 14\u00a0Patienten (5,1\u202f%) erfasst. Die meisten dieser Patienten wurden leblos aufgefunden und konnten nicht wiederbelebt werden. Drei Patienten wurden noch in eine Klinik transportiert, starben aber dort. Bei den letalen Intoxikationen waren prinzipiell geeignete Antidota nur in 3 F\u00e4llen verf\u00fcgbar; bei diesen waren Wiederbelebungsma\u00dfnahmen aber nicht mehr indiziert oder nicht erfolgreich.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Schlussfolgerung<\/jats:title>\n            <jats:p>Diese Untersuchung zeigt, dass sich die meisten schweren und t\u00f6dlichen Intoxikationen im h\u00e4uslichen Umfeld in suizidaler Absicht mithilfe von Arzneimitteln ereignen. Aufgrund der m\u00f6glichen Zahl unterschiedlicher Substanzen und mit Blick auf die Kombinationsm\u00f6glichkeiten ist es Rettungsdienstpersonal nicht m\u00f6glich, alle Effekte und Stoffinteraktionen einsch\u00e4tzen zu k\u00f6nnen. Bei einem fr\u00fchzeitigen Kontakt zu einer GIZ kann diese durch ihren Zugriff auf gro\u00dfe Datenbanken wichtige Empfehlungen hinsichtlich symptomatischer oder weiterf\u00fchrender Therapie und zu geeigneten Zielekrankenh\u00e4usern geben.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphic abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00101-025-01544-3","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T13:55:37Z","timestamp":1749822937000},"page":"429-438","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Schwere\u00a0und\u00a0letale\u00a0Vergiftungsf\u00e4lle im Rettungsdienst\u00a0\u2013 eine 5-Jahres-Analyse des Giftinformationszentrum-Nord","Severe and fatal cases of poisoning in the emergency medical services\u2014A 5-year analysis from the Poisoning Information Center North"],"prefix":"10.1007","volume":"74","author":[{"given":"Markus","family":"Roessler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Anja","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schaper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"1544_CR1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00103-017-2550-9","volume":"60","author":"H Desel","year":"2017","unstructured":"Desel\u00a0H, Hentschel\u00a0H, St\u00fcrer\u00a0A (2017) Vergiftungen in Deutschland: Giftinformationszentren, medizinische Versorgung und nationales Monitoring. 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