{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:44:38Z","timestamp":1764251078942,"version":"3.46.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesiologie"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Transfusion von Thrombozytenkonzentraten\u00a0ist eine etablierte Therapie bei Thrombozytopenie oder Thrombozytenfunktionsst\u00f6rungen. Die neue internationale Leitlinie der Association for the Advancement of Blood and Biotherapies in Zusammenarbeit mit der International Collaboration for Transfusion Medicine Guidelines\u00a0basiert auf 21\u00a0randomisierten und 13\u00a0Beobachtungsstudien, in denen restriktive und liberale Transfusionsstrategien verglichen wurden. Die Evidenz zeigt, dass restriktive Strategien weder die 30-Tages-Mortalit\u00e4t noch das Risiko schwerer Blutungen (WHO-Grad\u00a03\u20134) signifikant erh\u00f6hen, jedoch mit einer geringeren Rate transfusionsassoziierter Nebenwirkungen, einer verbesserten Ressourcenverf\u00fcgbarkeit und niedrigeren Kosten einhergehen. Die Leitlinie unterst\u00fctzt restriktive Transfusionsstrategien, betont jedoch die Notwendigkeit individueller klinischer Entscheidungen unter Ber\u00fccksichtigung von Symptomen, Komorbidit\u00e4ten und Patientenpr\u00e4ferenzen.<\/jats:p>","DOI":"10.1007\/s00101-025-01603-9","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:57:53Z","timestamp":1762199873000},"page":"839-842","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidenzbasiert und praxisnah: die neue Leitlinie zur Thrombozytentransfusion im Fokus","Evidence-based and practical: scrutiny of the new guidelines on platelet transfusion"],"prefix":"10.1007","volume":"74","author":[{"given":"Philipp","family":"P\u00fctz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Piekarski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"issue":"1","key":"1603_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/trf.16134","volume":"61","author":"M Hill-Strathy","year":"2021","unstructured":"Hill-Strathy\u00a0M, Pinkerton\u00a0PH, Thompson\u00a0TA et\u00a0al (2021) Evaluating the appropriateness of platelet transfusions compared with evidence-based platelet guidelines: an audit of platelet transfusions at 57\u00a0hospitals. 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M.\u00a0Coburn ist Vorsitzender des Forschungsausschusses der European Society of Anaesthesiology and Intensive Care (ESAIC), Vorsitzender des Forums Nachhaltigkeit sowie Vorsitzender des Klinischen Studienzentrums der Deutschen Gesellschaft f\u00fcr An\u00e4sthesiologie und Intensivmedizin (DGAI); er erhielt Referentenhonorare von Baxter, Dr\u00e4ger und Abbott. F.\u00a0Piekarski erhielt Unterst\u00fctzung f\u00fcr berufliche Weiterbildungen von Edwards Lifesciences und Abbott, erh\u00e4lt Honorare von CSL Behring und ist Vorsitzender des Arbeitskreises \u201ePoint of Care\u201c der Interdisziplin\u00e4ren Arbeitsgemeinschaft f\u00fcr Klinische H\u00e4motherapie (IAKH). Die angegebenen Beziehungen stehen in keinem Zusammenhang mit dem Inhalt des Manuskripts und haben diesen nicht beeinflusst.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}