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Vernebelte Medikamente sollen u.\u202fa. die mukozili\u00e4re Clearance verbessern oder eine Bronchoobstruktion behandeln. Es existieren allerdings keine Empfehlungen, wie die Verneblungstherapie bei dieser Patientengruppe am besten durchgef\u00fchrt werden sollte.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ziel der Arbeit<\/jats:title>\n                    <jats:p>Ziel der In-vitro-Studie war es herauszufinden, mit welchem Aerosolgenerator und \u00fcber welches Interface die Medikamentendepositionsrate bei spontan atmenden, tracheotomierten Patient:innen am h\u00f6chsten ist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material und Methoden<\/jats:title>\n                    <jats:p>Die Medikamentendepositionsraten eines Jet- (Cirrus\u2122\u00a02, Intersurgical Beatmungsger\u00e4te GmbH, Sankt Augustin, DE) und eines Vibrating-mesh-Verneblers (Aerogen\u00ae Solo, Aerogen Ltd., Galway, IE) wurden in einem In-vitro-Modell spontan und Raumluft atmender, tracheotomierter Patient:innen verglichen. Das Aerosol wurde sowohl \u00fcber 2 verschiedene Verneblermasken als auch \u00fcber ein T\u2011St\u00fcck, das direkt an die Trachealkan\u00fcle angeschlossen wurde, verabreicht.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>\n                      Der Meshvernebler konnte mittels T\u2011St\u00fcck die h\u00f6chste Medikamentendepositionsrate erreichen (19,32\u202f\u00b1\u20094,29\u202f%). Diese war signifikant h\u00f6her (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090,008) als die beste Depositionsrate des Jetverneblers, die dieser unter Verwendung einer Gesichtsmaske erreichte (12,33\u202f\u00b1\u20091,38\u202f%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Die regelhafte Verwendung von Vibrating-mesh-Verneblern, die zur Medikamentenverneblung mittels T\u2011St\u00fcck direkt an die Trachealkan\u00fcle konnektiert werden, k\u00f6nnte die Aerosoltherapie von spontan atmenden, tracheotomierten Patient:innen verbessern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00101-025-01618-2","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:17:13Z","timestamp":1766089033000},"page":"12-19","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aerosoltherapie bei spontan atmenden, tracheotomierten Patienten: eine In-vitro-Studie","Aerosol therapy in spontaneously breathing tracheostomized patients: an in vitro study"],"prefix":"10.1007","volume":"75","author":[{"given":"Y.","family":"Kropp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Barthel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Beck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tsagogiorgas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"1618_CR1","doi-asserted-by":"publisher","first-page":"847","DOI":"10.4187\/respcare.11495","volume":"69","author":"FA Albuainain","year":"2024","unstructured":"Albuainain\u00a0FA, Li\u00a0J (2024) Aerosol Delivery to Simulated Spontaneously Breathing Tracheostomized Adult Model With and Without Humidification. 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