{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:31:00Z","timestamp":1790310660935,"version":"4.1.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Anaesthesiologie"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 24-year-old male experienced cardiac arrest following a generalized seizure shortly after being stopped at a border control. Paramedics administered intranasal midazolam, after which the patient became asystolic and underwent prolonged cardiopulmonary resuscitation. The patient had a history of cocaine abuse. Suspected acute cocaine intoxication prompted the administration of intravenous lipid emulsion (ILE). Shortly thereafter, the rhythm converted to ventricular fibrillation and return of spontaneous circulation occurred 80 min after the arrest. No underlying cause was identified on diagnostic imaging or coronary angiography. Toxicological testing confirmed markedly elevated cocaine levels, consistent with body stuffing. Despite initial stabilization in the intensive care unit (ICU), the patient developed multiorgan failure and progressive cerebral edema leading to malignant intracranial hypertension. The patient died within 24 h of admission. This case highlights the potentially fulminant course of cocaine toxicity and suggests that lipid emulsion therapy may be considered as an early rescue intervention in refractory cocaine-induced cardiac arrest when conventional treatment fails.<\/jats:p>","DOI":"10.1007\/s00101-026-01659-1","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:52:58Z","timestamp":1772805178000},"page":"344-347","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful lipid rescue therapy after prolonged cardiac arrest in acute cocaine intoxication","Erfolgreiche Lipid-Rescue-Therapie nach l\u00e4ngerem Herzstillstand bei akuter Kokainvergiftung"],"prefix":"10.1007","volume":"75","author":[{"given":"Anja","family":"Laska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Dilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schnaidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes S.","family":"Meidert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Huge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"1659_CR1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.amjcard.2012.10.022","volume":"111","author":"NP Arora","year":"2013","unstructured":"Arora\u00a0NP, Berk\u00a0WA, Aaron\u00a0CK, Williams\u00a0KA (2013) Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Am J Cardiol 111:445\u2013447","journal-title":"Am J Cardiol"},{"key":"1659_CR2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0457-5","volume":"18","author":"G Cave","year":"2014","unstructured":"Cave\u00a0G, Harvey\u00a0MG (2014) Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients? Critical Care 18:457","journal-title":"Critical Care"},{"key":"1659_CR3","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1111\/bcp.15717","volume":"89","author":"A Graudins","year":"2023","unstructured":"Graudins\u00a0A, Lee\u00a0HMD, Tong\u00a0LKR (2023) Intravenous Lipid Emulsion does NOT have a\u00a0role in severe poisoning: CON. British Journal of Clinical Pharmacology 89:1719\u20131723","journal-title":"British Journal of Clinical Pharmacology"},{"key":"1659_CR4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00101-011-1848-5","volume":"60","author":"V Huge","year":"2011","unstructured":"Huge\u00a0V, Baschnegger\u00a0H, Moehnle\u00a0P et\u00a0al (2011) Amitriptyline-induced cardiac arrest : treatment with fat emulsion. Anaesthesist 60:541\u2013545","journal-title":"Anaesthesist"},{"key":"1659_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051396","volume":"15","author":"K Jaffal","year":"2023","unstructured":"Jaffal\u00a0K, Chevillard\u00a0L, M\u00e9garbane\u00a0B (2023) Lipid emulsion to treat acute poisonings: mechanisms of action, indications, and controversies. Pharmaceutics 15:1396","journal-title":"Pharmaceutics"},{"key":"1659_CR6","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1111\/j.1365-2044.2011.06895.x","volume":"66","author":"R Jakkala-Saibaba","year":"2011","unstructured":"Jakkala-Saibaba\u00a0R, Morgan\u00a0PG, Morton\u00a0GL (2011) Treatment of cocaine overdose with lipid emulsion. Anaesthesia 66:1168\u20131170","journal-title":"Anaesthesia"},{"key":"1659_CR7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.18433\/J30D2V","volume":"20","author":"N Motayagheni","year":"2017","unstructured":"Motayagheni\u00a0N, Phan\u00a0S, Nozari\u00a0A, Atala\u00a0A (2017) Lipid emulsion, more than reversing bupivacaine cardiotoxicity: potential organ protection. Journal of Pharmacy & Pharmaceutical Sciences 20:329\u2013331","journal-title":"Journal of Pharmacy & Pharmaceutical Sciences"},{"key":"1659_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s13181-016-0550-z","volume":"13","author":"Net ACOMTPA","year":"2017","unstructured":"Net ACOMTPA (2017) ACMT position statement: guidance for the use of intravenous lipid emulsion. Journal of Medical Toxicology 13:124\u2013125","journal-title":"Journal of Medical Toxicology"},{"key":"1659_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jcfm.2005.12.002","volume":"14","author":"GA Norfolk","year":"2007","unstructured":"Norfolk\u00a0GA (2007) The fatal case of a cocaine body-stuffer and a literature review - towards evidence based management. J\u00a0Forensic Leg Med 14:49\u201352","journal-title":"J Forensic Leg Med"},{"key":"1659_CR10","first-page":"527","volume":"119","author":"C Rauschert","year":"2022","unstructured":"Rauschert\u00a0C, M\u00f6ckl\u00a0J, Seitz\u00a0NN et\u00a0al (2022) The Use of Psychoactive Substances in Germany. Dtsch Arztebl Int 119:527\u2013534","journal-title":"Dtsch Arztebl Int"},{"key":"1659_CR11","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.ccc.2012.07.003","volume":"28","author":"JL Zimmerman","year":"2012","unstructured":"Zimmerman\u00a0JL (2012) Cocaine intoxication. Crit Care Clin 28:517\u2013526","journal-title":"Crit Care Clin"}],"container-title":["Die Anaesthesiologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-026-01659-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00101-026-01659-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00101-026-01659-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:04:19Z","timestamp":1777467859000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00101-026-01659-1"}},"subtitle":["A\u00a0case report and mini-review","Ein Fallbericht und Mini-Review"],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1659"],"URL":"https:\/\/doi.org\/10.1007\/s00101-026-01659-1","relation":{},"ISSN":["2731-6858","2731-6866"],"issn-type":[{"value":"2731-6858","type":"print"},{"value":"2731-6866","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"assertion":[{"value":"14 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A.S.\u00a0Meidert has received speaker honoraria from Edwards Lifescience and is inventor of the pending patent \u201cVorrichtung und Verfahren zur Erfassung von zumindest zwei Spurengasen in einer Ausatemluft\u201d (\u201cDevice and method for detecting at least two trace gases in exhaled air\u201d) EP\u00a04644865A. A.\u00a0Laska, M.\u00a0Moser, T.\u00a0Dilger, T.\u00a0Schnaidt and V.\u00a0Huge declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This manuscript presents an anonymized single case report. According to institutional regulations, ethics committee approval was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}