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Selye beobachtete an Ratten, die er unterschiedlichen physikalischen oder chemischen Noxen unterwarf, stereotype hormonelle Reaktionen und f\u00fchrte in sp\u00e4teren Arbeiten den heute ubiquit\u00e4r verwendeten Begriff \u201eStress\u201c hierf\u00fcr ein. Dabei entlehnte er den Begriff aus der Physik (\u201estress and strain\u201c), wo er die Verformung eines Festk\u00f6rpers durch einwirkende Kr\u00e4fte beschreibt. Selye r\u00e4umte sp\u00e4ter ein, dass es im biomedizinischen Kontext besser gewesen w\u00e4re, statt der ausl\u00f6senden Faktoren \u201eStress\u201c die Belastungs\n                    <jats:italic>effekte<\/jats:italic>\n                    \u2013\u00a0also \u201estrain\u201c\u00a0\u2013 zur Beschreibung des allgemeinen Anpassungssyndroms zu nutzen. Analog zum \u00dcberdehnen eines Festk\u00f6rpers bis zum Bruch, wird beim \u00dcberschreiten der Reparatur- und Defensivsysteme lebender Organismen ein \u201epoint of no return\u201c erreicht, der durch Organsch\u00e4den bis hin zum Tod charakterisiert ist. Selyes Forschung hat grundlegend zum Verst\u00e4ndnis der Sch\u00e4digungsreaktionen gerade auch in der Intensivmedizin beigetragen. So lassen sich z.\u202fB. traumainduzierte Stresseffekte in chirurgischen Patienten durch Analgesie und Sedierung modulieren. In der vorliegenden \u00dcbersicht sollen die Fortschritte in der medizinischen Stressforschung, insbesondere das Konzept der Allostase und der Hormese sowie deren zugrunde liegenden molekularen Mechanismen f\u00fcr das \u00e4rztliche Handeln am Beispiel des Organversagens bei Sepsis erl\u00e4utert werden.\n                  <\/jats:p>","DOI":"10.1007\/s00101-026-01735-6","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:17:59Z","timestamp":1790230679000},"page":"723-730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stress, Allostase und Organversagen","Stress, allostasis and organ failure"],"prefix":"10.1007","volume":"75","author":[{"given":"Michael","family":"Bauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Wetzker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"1735_CR1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1056\/NEJMoa1705716","volume":"378","author":"D Annane","year":"2018","unstructured":"Annane\u00a0D (2018) Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. 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