{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T20:50:12Z","timestamp":1675284612527},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bundesgesundheitsbl."],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00103-014-2093-2","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T11:40:25Z","timestamp":1417434025000},"page":"146-153","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetik und Pr\u00e4vention am Beispiel genetischer Aortensyndrome (GAS) und des Marfan-Syndroms"],"prefix":"10.1007","volume":"58","author":[{"given":"Y.","family":"von Kodolitsch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. R.","family":"Blankart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kallenbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. N.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"2093_CR1","unstructured":"Centers of Disease Control and Prevention (2007) WISQARS leading causes of death reports, 1999\u20132007. 20 leading causes of death, United States 2007, all races, both sexes. http:\/\/webappcdcgov\/cgi-bin\/brokerexe . Zugegriffen: 3. Nov. 2012"},{"key":"2093_CR2","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1161\/CIRCULATIONAHA.112.000483","volume":"127","author":"DP Howard","year":"2013","unstructured":"Howard DP, Banerjee A, Fairhead JF, Perkins J, Silver LE, Rothwell PM (2013) Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study. Circulation 127:2031\u20132037","journal-title":"Circulation"},{"key":"2093_CR3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jama.283.7.897","volume":"283","author":"PG Hagan","year":"2000","unstructured":"Hagan PG, Nienaber CA, Isselbacher EM et al (2000) The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA 283:897\u2013903","journal-title":"JAMA"},{"key":"2093_CR4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jacc.2003.08.054","volume":"43","author":"JL Januzzi","year":"2004","unstructured":"Januzzi JL, Isselbacher EM, Fattori R et al (2004) Characterizing the young patient with aortic dissection: results from the International Registry of Aortic Dissection (IRAD). J Am Coll Cardiol 43:665\u2013669","journal-title":"J Am Coll Cardiol"},{"key":"2093_CR5","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1086\/520125","volume":"81","author":"L Faivre","year":"2007","unstructured":"Faivre L, Collod-Beroud G, Loeys BL et al (2007) Effect of mutation type and location on clinical outcome in 1013 probands with Marfan syndrome or related phenotypes and FBN1 mutations: an international study. Am J Hum Genet 81:454\u2013466","journal-title":"Am J Hum Genet"},{"key":"2093_CR6","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.ijcard.2012.10.044","volume":"168","author":"K Kuhne","year":"2012","unstructured":"Kuhne K, Keyser B, Groene EF et al (2012) FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression. Int J Cardiol 168:953\u2013959","journal-title":"Int J Cardiol"},{"key":"2093_CR7","doi-asserted-by":"crossref","first-page":"e81281","DOI":"10.1371\/journal.pone.0081281","volume":"8","author":"A Aydin","year":"2013","unstructured":"Aydin A, Adsay BA, Sheikhzadeh S et al (2013) Observational cohort study of ventricular arrhythmia in adults with Marfan syndrome caused byFBN1 mutations. PLoS One 8:e81281","journal-title":"PLoS One"},{"key":"2093_CR8","doi-asserted-by":"crossref","unstructured":"Sheikhzadeh S, Sondermann C, Rybczynski M et al (2013) Comprehensive analysis of dural ectasia in 150 patients with a causative FBN1 mutation. Clin Genet 86(3):238\u2013245","DOI":"10.1111\/cge.12264"},{"key":"2093_CR9","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0140-6736(98)12448-0","volume":"354","author":"R Fattori","year":"1999","unstructured":"Fattori R, Nienaber CA, Descovich B et al (1999) Importance of dural ectasia in phenotypic assessment of Marfan\u2019s syndrome. Lancet 354:910\u2013913","journal-title":"Lancet"},{"key":"2093_CR10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1399-0004.2011.01771.x","volume":"82","author":"S Sheikhzadeh","year":"2012","unstructured":"Sheikhzadeh S, Kade C, Keyser B et al (2012) Analysis of phenotype and genotype information for the diagnosis of Marfan syndrome. Clin Genet 82:240\u2013247","journal-title":"Clin Genet"},{"key":"2093_CR11","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1056\/NEJMoa055695","volume":"355","author":"BL Loeys","year":"2006","unstructured":"Loeys BL, Schwarze U, Holm T et al (2006) Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med 355:788\u2013798","journal-title":"N Engl J Med"},{"key":"2093_CR12","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","volume":"47","author":"BL Loeys","year":"2010","unstructured":"Loeys BL, Dietz HC, Braverman AC et al (2010) The revised Ghent nosology for the Marfan syndrome. J Med Genet 47:476\u2013485","journal-title":"J Med Genet"},{"issue":"8","key":"2093_CR13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/gim.2014.11","volume":"16","author":"G Maccarrick","year":"2014","unstructured":"Maccarrick G, Black JH 3rd, Bowdin S et al (2014) Loeys-Dietz syndrome: a primer for diagnosis and management. Genet Med 16(8):576\u2013587","journal-title":"Genet Med"},{"key":"2093_CR14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.genom.8.080706.092303","volume":"9","author":"DM Milewicz","year":"2008","unstructured":"Milewicz DM, Guo DC, Tran-Fadulu V et al (2008) Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction. Annu Rev Genomics Hum Genet 9:283\u2013302","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"2093_CR15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCRESAHA.113.300675","volume":"113","author":"E Gillis","year":"2013","unstructured":"Gillis E, Van Laer L, Loeys BL (2013) Genetics of thoracic aortic aneurysm: at the crossroad of transforming growth factor-\u03b2 signaling and vascular smooth muscle cell contractility. Circulat Res 113:327\u2013340","journal-title":"Circulat Res"},{"key":"2093_CR16","doi-asserted-by":"crossref","first-page":"1233151","DOI":"10.1126\/science.1233151","volume":"341","author":"A Aiuti","year":"2013","unstructured":"Aiuti A, Biasco L, Scaramuzza S et al (2013) Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science 341:1233151","journal-title":"Science"},{"key":"2093_CR17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1056\/NEJMoa1000164","volume":"363","author":"S Hacein-Bey-Abina","year":"2010","unstructured":"Hacein-Bey-Abina S, Hauer J, Lim A et al (2010) Efficacy of gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 363:355\u2013364","journal-title":"N Engl J Med"},{"key":"2093_CR18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1006\/bbrc.1998.9241","volume":"249","author":"LA Phylactou","year":"1998","unstructured":"Phylactou LA, Tsipouras P, Kilpatrick MW (1998) Hammerhead ribozymes targeted to the FBN1 mRNA can discriminate a single base mismatch between ribozyme and target. Biochem Biophys Res Commun 249:804\u2013810","journal-title":"Biochem Biophys Res Commun"},{"key":"2093_CR19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nbt.2884","volume":"32","author":"H Yin","year":"2014","unstructured":"Yin H, Xue W, Chen S et al (2014) Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nat Biotechnol 32:551\u2013553","journal-title":"Nat Biotechnol"},{"key":"2093_CR20","doi-asserted-by":"crossref","unstructured":"Zaradzki M, Arif R, Schwill S et al (2013) AP-1 decoy oligodeoxynucleotide inhibition of matrix metalloproteinase expression in vascular smooth muscle cells of fibrillin-1-deficient mgR\/mgR-mice. Thorac Cardiovasc Surg 61:S23","DOI":"10.1055\/s-0032-1332283"},{"key":"2093_CR21","unstructured":"Hurrelmann K, Klotz T, Haisch J (2004) Einf\u00fchrung: Krankheitspr\u00e4vention und Gesundheitsf\u00f6rderung. In: Hurrelmann K, Altgeld T (Hrsg) Lehrbuch Pr\u00e4vention und Gesundheitsf\u00f6rderung. H. Huber, Bern, S\u00a013\u201324"},{"key":"2093_CR22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-3-642-12584-3_10","volume-title":"Medizinische Psychologie und Soziologie","author":"H Faller","year":"2010","unstructured":"Faller H, Lang H (2010) F\u00f6rderung und Erhaltung von Gesundheit: Pr\u00e4vention. In: Medizinische Psychologie und Soziologie. Springer, Heidelberg, S\u00a0311\u2013337"},{"key":"2093_CR23","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/pd.4008","volume":"32","author":"F Coron","year":"2012","unstructured":"Coron F, Rousseau T, Jondeau G et al (2012) What do French patients and geneticists think about prenatal and preimplantation diagnoses in Marfan syndrome? Prenat Diagn 32:1318\u20131323","journal-title":"Prenat Diagn"},{"key":"2093_CR24","unstructured":"Madelin R (2009) The voice of 12,000 patients. Experiences and expectations of rare disease patients on diagnosis and care in Europe. http:\/\/www.eurordis.org\/IMG\/pdf\/voice_12000_patients\/EURORDISCARE_FULLBOOKr.pdf . Zugegriffen: 21. Sept. 2014"},{"key":"2093_CR25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.healthpol.2012.02.003","volume":"105","author":"K Roll","year":"2012","unstructured":"Roll K (2012) The influence of regional health care structures on delay in diagnosis of rare diseases: the case of Marfan Syndrome. Health Policy 105:119\u2013127","journal-title":"Health Policy"},{"key":"2093_CR26","first-page":"483","volume":"105","author":"M Arslan-Kirchner","year":"2008","unstructured":"Arslan-Kirchner M, von Kodolitsch Y, Schmidtke J (2008) Genetische Diagnostik beim Marfan-Syndrom und verwandten Erkrankungen: Bedeutung des klinischen Managements. Dtsch Arztebl Int 105:483\u2013491","journal-title":"Dtsch Arztebl Int"},{"key":"2093_CR27","first-page":"A326","volume":"100","author":"Y von Kodolitsch","year":"2003","unstructured":"von Kodolitsch Y, Baumgart D, Eggebrecht H et al (2003) Das akute Aortensyndrom. Dtsch \u00c4rztebl 100:A326\u2013A333","journal-title":"Dtsch \u00c4rztebl"},{"key":"2093_CR28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/qjmed\/hcs008","volume":"105","author":"S Sheikhzadeh","year":"2012","unstructured":"Sheikhzadeh S, Kusch ML, Rybczynski M et al (2012) A simple clinical model to estimate the probability of Marfan syndrome. QJM 105:527\u2013535","journal-title":"QJM"},{"issue":"17","key":"2093_CR29","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1136\/heartjnl-2013-304709","volume":"100","author":"RM Radke","year":"2014","unstructured":"Radke RM, Baumgartner H (2014) Diagnosis and treatment of Marfan syndrome: an update. Heart 100(17):1382\u20131391","journal-title":"Heart"},{"issue":"2","key":"2093_CR30","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1111\/apa.12072","volume":"102","author":"GC Mueller","year":"2012","unstructured":"Mueller GC, Stark V, Steiner K, Weil J, von Kodolitsch Y, Mir TS (2012) The Kid-Short Marfan Score (Kid-SMS) \u2013 An easy executable risk score for suspected paediatric Marfan patients. Acta Paediatr 102(2):e84\u201389","journal-title":"Acta Paediatr"},{"key":"2093_CR31","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/CIRCULATIONAHA.108.841981","volume":"120","author":"P Matt","year":"2009","unstructured":"Matt P, Schoenhoff F, Habashi J et al (2009) Circulating transforming growth factor-beta in Marfan syndrome. Circulation 120:526\u2013532","journal-title":"Circulation"},{"key":"2093_CR32","unstructured":"Hillebranda M, Millot N, Sheikhzadeh S et al (2014) Total serum transforming growth factor-beta 1 is elevated in the entire spectrum of genetic aortic syndromes. Clin Cardiol. doi:1002\/clc.22320"},{"key":"2093_CR33","unstructured":"Bartmann U (2007) Verhaltensmodifikation als Methode der Sozialen Arbeit: ein Leitfaden. DGVT, T\u00fcbingen"},{"key":"2093_CR34","doi-asserted-by":"crossref","unstructured":"von Kodolitsch Y, Rybczynski M (2007) Marfan-Syndrom: Sport und Fitness. In: Marfan-Syndrom. Ein Ratgeber f\u00fcr Patienten, Angeh\u00f6rige und Betreuende. Steinkopff, Darmstadt","DOI":"10.1007\/978-3-7985-1566-6_17"},{"key":"2093_CR35","unstructured":"e.\u00a0V. M-H (2006) Marfan-Syndrom: ein Ratgeber f\u00fcr Patienten, Angeh\u00f6rige und Betreuende. Steinkopff, Darmstadt"},{"key":"2093_CR36","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng1116","volume":"33","author":"ER Neptune","year":"2003","unstructured":"Neptune ER, Frischmeyer PA, Arking DE et al (2003) Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nat Genet 33:407\u2013411","journal-title":"Nat Genet"},{"key":"2093_CR37","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1172\/JCI200422715","volume":"114","author":"CM Ng","year":"2004","unstructured":"Ng CM, Cheng A, Myers LA et al (2004) TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest 114:1586\u20131592","journal-title":"J Clin Invest"},{"key":"2093_CR38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nm1536","volume":"13","author":"RD Cohn","year":"2007","unstructured":"Cohn RD, van Erp C, Habashi JP et al (2007) Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nature Med 13:204\u2013210","journal-title":"Nature Med"},{"key":"2093_CR39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","volume":"312","author":"JP Habashi","year":"2006","unstructured":"Habashi JP, Judge DP, Holm TM et al (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312:117\u2013121","journal-title":"Science"},{"key":"2093_CR40","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","volume":"358","author":"BS Brooke","year":"2008","unstructured":"Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B, Dietz HC 3rd (2008) Angiotensin II blockade and aortic-root dilation in Marfan\u2019s syndrome. N Engl J Med 358:2787\u20132795","journal-title":"N Engl J Med"},{"issue":"45","key":"2093_CR41","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1093\/eurheartj\/eht334","volume":"34","author":"M Groenink","year":"2013","unstructured":"Groenink M, den Hartog AW, Franken R et al (2013) Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial. Eur Heart J 34(45):3491\u20133500","journal-title":"Eur Heart J"},{"key":"2093_CR42","doi-asserted-by":"crossref","first-page":"e266","DOI":"10.1161\/CIR.0b013e3181d4739e","volume":"121","author":"LF Hiratzka","year":"2010","unstructured":"Hiratzka LF, Bakris GL, Beckman JA et al (2010) 2010 ACCF\/AHA\/AATS\/ACR\/ASA\/SCA\/SCAI\/SIR\/STS\/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation 121:e266\u2013e369","journal-title":"Circulation"},{"key":"2093_CR43","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.jcmg.2013.08.009","volume":"6","author":"K Kallenbach","year":"2013","unstructured":"Kallenbach K, Sundt TM, Marwick TH (2013) Aortic surgery for ascending aortic aneurysms under 5.0\u00a0cm in diameter in the presence of bicuspid aortic valve. JACC Cardiovasc Imaging 6:1321\u20131326","journal-title":"JACC Cardiovasc Imaging"},{"key":"2093_CR44","doi-asserted-by":"crossref","unstructured":"von Kodolitsch Y, Robinson PN, Berger J (2014) When should surgery be performed in Marfan syndrome and other connective tissue disorders to protect against type A dissection? In: Bonser R, Haverich A, Mascaro J, Pagano D (Hrsg) Controversies in Aortic Dissection and Aneurysmal Disease. Springer, London","DOI":"10.1007\/978-1-4471-5622-2_2"},{"key":"2093_CR45","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/BF02470744","volume":"17","author":"HH Bentall","year":"1987","unstructured":"Bentall HH (1987) Operation for ascending aortic aneurysm and aortic regurgitation\u2013pathological influence on survival. Jpn J Surg 17:425\u2013430","journal-title":"Jpn J Surg"},{"key":"2093_CR46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0022-5223(19)34225-4","volume":"105","author":"MAI Sarsam","year":"1993","unstructured":"Sarsam MAI, Yacoub M (1993) Remodeling of the aortic valve anulus. J Thorac Cardiovasc Surg 105:435\u2013438","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2093_CR47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0022-5223(19)34942-6","volume":"103","author":"TE David","year":"1992","unstructured":"David TE, Feindel CM (1992) An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. J Thorac Cardiovasc Surg 103:617\u2013621. (discussion 622)","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2093_CR48","doi-asserted-by":"crossref","first-page":"S764","DOI":"10.1016\/j.athoracsur.2006.10.097","volume":"83","author":"K Kallenbach","year":"2007","unstructured":"Kallenbach K, Baraki H, Khaladj N et al (2007) Aortic valve-sparing operation in Marfan syndrome: what do we know after a decade? Ann Thorac Surg 83:S764\u2013S768. (discussion S785\u2013790)","journal-title":"Ann Thorac Surg"},{"key":"2093_CR49","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/hrt.2010.210286","volume":"97","author":"U Benedetto","year":"2011","unstructured":"Benedetto U, Melina G, Takkenberg JJM, Roscitano A, Angeloni E, Sinatra R (2011) Surgical management of aortic root disease in Marfan syndrome: a systematic review and meta-analysis. Heart (British Cardiac Society) 97:955\u2013958","journal-title":"Heart (British Cardiac Society)"},{"key":"2093_CR50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1750-1172-9-90","volume":"9","author":"D Achelrod","year":"2014","unstructured":"Achelrod D, Blankart CR, Linder R, von Kodolitsch Y, Stargardt T (2014) The economic impact of Marfan syndrome: a non-experimental, retrospective, population-based matched cohort study. Orphanet J Rare Dis 9:90","journal-title":"Orphanet J Rare Dis"}],"container-title":["Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00103-014-2093-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00103-014-2093-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00103-014-2093-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T10:34:44Z","timestamp":1598524484000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00103-014-2093-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["2093"],"URL":"https:\/\/doi.org\/10.1007\/s00103-014-2093-2","relation":{},"ISSN":["1436-9990","1437-1588"],"issn-type":[{"value":"1436-9990","type":"print"},{"value":"1437-1588","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,2]]}}}