{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:52:22Z","timestamp":1789912342882,"version":"4.0.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bundesgesundheitsbl"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Seit wenigen Jahrzehnten ist in Deutschland ein R\u00fcckgang der Karieslast in allen Altersgruppen feststellbar. Hierf\u00fcr wird die regelm\u00e4\u00dfige Anwendung von Fluoridpr\u00e4paraten als wesentliche Ursache beschrieben. Es gilt als gesichert, dass f\u00fcr den R\u00fcckgang der Kariespr\u00e4valenz und Karieserfahrung die lokale Fluoridapplikation, insbesondere durch fluoridhaltige Zahnpasten und Fluoridlacke, auf die Zahnoberfl\u00e4chen in der Mundh\u00f6hle verantwortlich ist. F\u00fcr die klinische Gesamtwirkung wurden einzelne Wirkungsmechanismen wie die Bildung einer Fluoridspeicherschicht, die Remineralisation sowie Effekte auf die bakterielle Plaque bestimmt. Diese Einzeleffekte k\u00f6nnen an Schmelz und Wurzeldentin bei Patienten jeden Alters wirksam werden. Dabei besteht eine Dosis-Wirkungs-Beziehung zwischen der Fluoridkonzentration in den angewendeten Pr\u00e4paraten und der durchschnittlich erzielten Kariesreduktion.<\/jats:p><jats:p>Es bestehen keine allgemeintoxikologischen Bedenken gegen\u00fcber der lokalen Fluoridanwendung. Fluoridzahnpasten sollen ab Durchbruch des ersten Milchzahns verwendet werden. Die Menge der verwendeten Zahnpasta ist auf die empfohlenen Volumina zu begrenzen, um die Entstehung von Schmelzfluorosen zu vermeiden. Die professionell durchgef\u00fchrte Applikation von hochkonzentrierten Fluoridlacken weist neben einer hohen karieshemmenden Effektivit\u00e4t auch bei erh\u00f6htem Kariesrisiko und bei bereits vorhandenen Demineralisationen besondere Vorteile auf. Dies trifft auch f\u00fcr die Anwendung am Wurzeldentin zu, wo durch Verwendung hochkonzentrierter Fluoridpr\u00e4parate signifikante prim\u00e4r- und sekund\u00e4rpr\u00e4ventive Effekte nachgewiesen wurden.<\/jats:p>","DOI":"10.1007\/s00103-021-03347-4","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T06:02:50Z","timestamp":1623391370000},"page":"830-837","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Verwendung von Fluoriden zur Kariespr\u00e4vention","Use of fluorides for caries prevention"],"prefix":"10.1007","volume":"64","author":[{"given":"Ulrich","family":"Schiffner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"3347_CR1","volume-title":"F\u00fcnfte Deutsche Mundgesundheitsstudie","author":"R Jordan","year":"2016","unstructured":"Jordan\u00a0R, Micheelis\u00a0W (2016) F\u00fcnfte Deutsche Mundgesundheitsstudie. 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