{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:15:51Z","timestamp":1790284551950,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Deutsches Krebsforschungszentrum (DKFZ)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bundesgesundheitsbl"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>Die Gruppe der Lippen\u2011, Mundh\u00f6hlen- und Pharynxkarzinome (ICD-10: C00\u2013C14) beschreibt eine heterogene Gruppe b\u00f6sartiger Tumoren, deren Inzidenz, Mortalit\u00e4t und \u00dcberleben sich nach Entit\u00e4t stark unterscheiden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ziel der Arbeit<\/jats:title>\n                    <jats:p>Diese Arbeit gibt eine detaillierte \u00dcbersicht epidemiologischer Ma\u00dfzahlen f\u00fcr diese Tumorentit\u00e4ten unter Ber\u00fccksichtigung der Heterogenit\u00e4t bez\u00fcglich Alter, Geschlecht, Lokalisation und Stadium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material und Methoden<\/jats:title>\n                    <jats:p>Inzidenz- und Mortalit\u00e4tsdaten f\u00fcr Deutschland f\u00fcr die Jahre 1999\u20132016 wurden aus der interaktiven Datenbank des Zentrums f\u00fcr Krebsregisterdaten (ZfKD) extrahiert. Alters- und Stadienverteilungen und altersstandardisiertes relatives 5\u2011Jahres-\u00dcberleben wurden auf dem gepoolten ZfKD-Datensatz (Diagnosejahre 1999\u20132017) berechnet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Im Jahr 2016 lagen die Inzidenz und Mortalit\u00e4t f\u00fcr alle Entit\u00e4ten insgesamt bei\u00a017,6 bzw. 7,0 pro 100.000 M\u00e4nnern und 6,5 bzw. 1,8 pro 100.000 Frauen. Das relative 5\u2011Jahres-\u00dcberleben f\u00fcr 2015\u20132017 lag bei 53\u202f% bzw. 63\u202f%. Es zeigten sich deutliche Unterschiede in der \u00dcberlebensrate und in der Alters- und Stadienverteilung zwischen den Entit\u00e4ten. Im zeitlichen Verlauf zeigte sich ein Anstieg des Alters bei Diagnose, insbesondere bei M\u00e4nnern, aber keine Ver\u00e4nderung in der Stadienverteilung. Trotzdem stieg das relative 5\u2011Jahres-\u00dcberleben zwischen 1999\u20132002 und 2013\u20132017 von 45\u202f% (M\u00e4nner) bzw. 59\u202f% (Frauen) auf 52\u202f% bzw. 63\u202f%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Die starke Heterogenit\u00e4t der untersuchten Tumoren verdeutlicht die Notwendigkeit einer nach Geschlechtern und Lokalisationen getrennten Betrachtung f\u00fcr eine aussagekr\u00e4ftige Interpretation der epidemiologischen Kennzahlen. Mit Ausbau der klinischen Krebsregistrierung werden in Zukunft zus\u00e4tzliche Analysen unter Einbezug weiterer wichtiger klinischer Faktoren m\u00f6glich sein.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00103-021-03368-z","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T14:04:43Z","timestamp":1625148283000},"page":"941-950","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mundh\u00f6hlen- und Pharynxkarzinome: Inzidenz, Mortalit\u00e4t und \u00dcberleben in Deutschland","Oral and pharyngeal cancer: incidence, mortality, and survival in Germany"],"prefix":"10.1007","volume":"64","author":[{"given":"Lina","family":"Jansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Moratin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Waldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Zaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Holleczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Nennecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Pritzkuleit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Plinkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Arndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"3368_CR1","doi-asserted-by":"publisher","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2015","unstructured":"Ferlay\u00a0J, Soerjomataram\u00a0I, Dikshit\u00a0R et\u00a0al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. 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