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Todesf\u00e4lle verantwortlich. Die Epidemiologie sepsisassoziierter Todesf\u00e4lle ist in Deutschland unzureichend verstanden, da Sepsis bisher nicht \u00fcber die deutsche unikausale Todesursachenstatistik erfasst werden kann.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ziel der Arbeit<\/jats:title>\n                <jats:p>Epidemiologie und Charakteristika sepsisassoziierter Krankenhaustodesf\u00e4lle sollen analysiert sowie regionale Unterschiede beschrieben werden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Retrospektive Beobachtungsstudie basierend auf der deutschlandweiten fallpauschalenbezogenen Krankenhausstatistik (DRG-Statistik) 2016. Sepsisassoziierte Krankenhaustodesf\u00e4lle wurden \u00fcber explizite und implizite Sepsis-ICD-10-GM(Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme,\u00a010. Revision,\u00a0German Modification)-Codierungen identifiziert. Verstorbene wurden anhand der klinischen Merkmale und ihres Wohnortes entsprechend Amtlichem Gemeindeschl\u00fcssel (AGS-5-Steller) charakterisiert. Basierend auf der Bev\u00f6lkerungsstatistik wurde der Anteil an den Gesamttodesf\u00e4llen ermittelt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>2016 gab es in Deutschland 58.689 mit explizit codierter Sepsis assoziierte Krankenhaustodesf\u00e4lle (14,1\u202f% aller Krankenhaustodesf\u00e4lle). Die Mortalit\u00e4t betrug 73\/100.000 Einwohner und variierte 1,8-fach zwischen den Bundesl\u00e4ndern und 7,9-fach zwischen den Kreisen. 6,4\u202f% der deutschlandweiten Todesf\u00e4lle waren sepsisassoziierte Krankenhaustodesf\u00e4lle. Dieser Anteil war am h\u00f6chsten in der Altersgruppe der 40- bis 64-J\u00e4hrigen (9,6\u202f%) und h\u00f6her bei M\u00e4nnern als bei Frauen (7,7\u202f% vs. 5,2\u202f%). Im Vergleich dazu betrug der Anteil von implizit codierten sepsisassoziierten Krankenhaustodesf\u00e4llen 47,2\u202f% an allen Krankenhaustodesf\u00e4llen und 21,6\u202f% an allen Todesf\u00e4llen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Auch wenn die direkte Todesursache nicht sicher ableitbar ist, l\u00e4sst sich aus dem hohen Anteil sepsisassoziierter Todesf\u00e4lle an den Krankenhaustodesf\u00e4llen der Bedarf weiterer Forschung und epidemiologischer Surveillance ableiten, zum Beispiel in Kohortenstudien oder auf Basis von multikausalen Todesursachenstatistiken.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00103-021-03427-5","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T21:03:32Z","timestamp":1636405412000},"page":"388-395","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sepsisassoziierte Todesf\u00e4lle in Deutschland: Charakteristika und regionale Variation","Sepsis-associated deaths in Germany: characteristics and regional variation"],"prefix":"10.1007","volume":"65","author":[{"given":"Carolin","family":"Fleischmann-Struzek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Reinhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"3427_CR1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer\u00a0M, Deutschman\u00a0CS, Seymour\u00a0CW et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). 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