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In Deutschland gibt es umfangreiche Daten zur Antibiotikaresistenz (AMR) und multiresistenten Erregern (MRE) in der Human- und Veterin\u00e4rmedizin sowie aus Untersuchungen in verschiedenen Umweltkompartimenten (Boden, Wasser, Abwasser). Die Erhebung erfolgt nach unterschiedlichen Vorgaben und Standards, was den Vergleich von Daten erschwert. Ein Fokus auf humantherapeutisch wichtige AMR und MRE ist hilfreich, um eine gewisse Orientierung vorzugeben. Die meisten Daten liegen sektor\u00fcbergreifend zu Methicillin-resistenten\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    und multiresistenten Enterobacterales wie\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    und\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    vor. Hier sind die Trends der Resistenzen heterogen. Der Einsatz von Antibiotika f\u00fchrt zur Selektion von MRE, was gut dokumentiert ist. Erfolge bei der Minimierung des Antibiotikaeinsatzes konnten in zur\u00fcckliegenden Jahren f\u00fcr einzelne Sektoren dargestellt und z.\u202fT. mit Erfolgen in der Eind\u00e4mmung von AMR und MRE korreliert werden (R\u00fcckgang MRSA in der Humanmedizin). Auch sektorspezifische Ma\u00dfnahmen zur Senkung der Last durch MRE und AMR sind notwendig, da Resistenzprobleme nicht generell eine Verkn\u00fcpfung mit anderen Sektoren aufweisen. Carbapenemresistenzen sind vor allem bei pathogenen Erregern vom Menschen nachweisbar. Colistinresistenzen kommen in verschiedenen Sektoren vor, zeigen aber dort jeweils verschiedene Mechanismen. Resistenzen gegen Reservesubstanzen wie Linezolid sind in Deutschland selten, sie zeigen aber einen konkreten One-Health-Bezug. Bestrebungen zur Harmonisierung von Methoden, z.\u202fB. im Bereich der antimikrobiellen Empfindlichkeitstestung und genombasierten Erreger- und AMR-Surveillance, sind ein wichtiger erster Schritt zu einer Vergleichbarkeit der verschiedenen Datenerhebungen.\n                  <\/jats:p>","DOI":"10.1007\/s00103-023-03713-4","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:30:39Z","timestamp":1684150239000},"page":"628-643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Therapierelevante Antibiotikaresistenzen im One-Health-Kontext","Therapy-relevant antibiotic resistances in a\u00a0One Health context"],"prefix":"10.1007","volume":"66","author":[{"given":"Guido","family":"Werner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muna","family":"Abu Sin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Bahrs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Brogden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea T.","family":"Fe\u00dfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"K\u00f6ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Kreienbrock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Kr\u00fcger-Haker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike","family":"Maechler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias W.","family":"Pletz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd-Alois","family":"Tenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Mielke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"issue":"Suppl 3","key":"3713_CR1","doi-asserted-by":"publisher","first-page":"S216","DOI":"10.1086\/591407","volume":"47","author":"M Singer","year":"2008","unstructured":"Singer\u00a0M, Nambiar\u00a0S, Valappil\u00a0T, Higgins\u00a0K, Gitterman\u00a0S (2008) Historical and regulatory perspectives on the treatment effect of antibacterial drugs for community-acquired pneumonia. 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