{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:24:57Z","timestamp":1778808297634,"version":"3.51.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bundesgesundheitsbl"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Living donor kidney transplantation (LDKT) is the preferred treatment for patients with end-stage kidney disease, offering longer graft survival and improved quality of life. However, LDKT poses risks to living donors. Black living donors face disproportionately higher risks of postdonation kidney disease than White counterparts, necessitating deeper understanding of the factors contributing to this disparity. This study evaluated the implementation of the <jats:italic>APOL1<\/jats:italic> Genetic Testing and Counseling Program at two transplant centers to improve donors\u2019 informed decision-making, which entailed examining the contextual factors influencing its adoption and sustainment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a\u00a0mixed-methods evaluation involving semistructured interviews guided by the Consolidated Framework for Implementation Research and surveys with transplant nephrologists to identify facilitators and barriers of intervention implementation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Eleven nephrologists participated. Key facilitators included alignment with clinical priorities, strong organizational support, and value attributed to the intended goal of enhancing donors\u2019 informed consent process and to the integration of culturally sensitive counseling practices. Key barriers included time constraints and the need for clear evidence-based guidelines. Participants reported high acceptability, appropriateness, feasibility, and sustainability of the <jats:italic>APOL1 <\/jats:italic>Program.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our study identified facilitators and barriers that should be addressed to ensure the <jats:italic>APOL1<\/jats:italic> program\u2019s sustainment and potential to improve donors\u2019 informed consent. Future research should leverage system-level implementation strategies to overcome identified barriers when taking the <jats:italic>APOL1<\/jats:italic> Genetic Testing and Counseling Program to scale.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00103-025-04068-8","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:29:04Z","timestamp":1749616144000},"page":"758-768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Contextual factors of implementing APOL1 genetic testing into living kidney donor clinical evaluation","Kontextfaktoren der Implementierung von APOL1-Gentests in der klinischen Bewertung von Lebendnierenspendern"],"prefix":"10.1007","volume":"68","author":[{"given":"James L.","family":"Merle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marissa C.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Gacki-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akansha","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9344-9928","authenticated-orcid":false,"given":"John","family":"Friedewald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-1998","authenticated-orcid":false,"given":"Elisa J.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"4068_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1053\/j.ajkd.2021.05.007","volume":"78","author":"KL Lentine","year":"2021","unstructured":"Lentine\u00a0KL, Pastan\u00a0S, Mohan\u00a0S et\u00a0al (2021) A roadmap for innovation to advance transplant access and outcomes: a\u00a0position statement from the national kidney foundation. 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