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Insbesondere die Besiedelung des Gastrointestinaltrakts mit multiresistenten Erregern gilt f\u00fcr verschiedene Gruppen als kritischer Risikofaktor f\u00fcr nosokomiale Infektionen. In diesem Zusammenhang r\u00fcckt die gezielte Dekolonisation des Darms zunehmend in den Fokus klinischer Forschung. Nicht absorbierbare Antibiotika galten lange als vielversprechender Ansatz zur lokalen Eradikation \u2013\u00a0die mittlerweile generierte Evidenz spricht jedoch nicht f\u00fcr die Wirksamkeit dieses Ansatzes. Alternativverfahren wie der f\u00e4kale Mikrobiota-Transfer zeigen in Einzelfallberichten und kleinen Studien vielversprechende Ergebnisse bei der Dekolonisation multiresistenter Erreger. Auch lebende biotherapeutische Produkte (Live Biotherapeutic Products\u00a0\u2013 LBPs) sowie bestimmte Probiotika werden als Optionen zur Modulation des Mikrobioms und zur Resistenzreduktion untersucht. Die Evidenzlage ist bislang heterogen und robuste randomisierte Studien fehlen gr\u00f6\u00dftenteils. Dieser Beitrag soll einen \u00dcberblick \u00fcber den aktuellen Kenntnisstand zur gastrointestinalen Besiedelung mit multiresistenten Erregern geben. Dar\u00fcber hinaus diskutiert er die klinische Relevanz nicht absorbierbarer Antibiotika bzw. den Stellenwert mikrobiombasierter Therapien im Kontext der globalen Antibiotikaresistenzkrise.<\/jats:p>","DOI":"10.1007\/s00103-026-04229-3","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:15:12Z","timestamp":1775564112000},"page":"590-596","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation des Darmmikrobioms zur Eradikation multiresistenter Erreger: Aktuelle Ans\u00e4tze und Perspektiven","Modulation of the gut microbiome for the eradication of multidrug-resistant pathogens: current approaches and perspectives"],"prefix":"10.1007","volume":"69","author":[{"given":"Tobias","family":"Weirauch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J. G. 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