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Auch in Deutschland sind die Entwicklungen der Resistenzsituation teilweise kritisch. Die Resistenzanteile der wichtigsten Erreger-Wirkstoff-Kombinationen werden mithilfe von Daten der Antibiotika-Resistenz-Surveillance (ARS) berechnet. F\u00fcr 4\u00a0Erreger-Wirkstoff-Kombinationen wurden im Aktionsplan der Deutschen Antibiotika-Resistenzstrategie (DART 2030) Reduktionsziele f\u00fcr Inzidenzen (Blutstrominfektionen pro 100.000 Einwohnende) f\u00fcr das Jahr 2030 festgelegt. W\u00e4hrend f\u00fcr die grampositiven Erreger Vancomycin-resistente\n                    <jats:italic>Enterococcus faecium<\/jats:italic>\n                    (VRE) und Methicillin-resistente\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) die Inzidenzen bereits im Zielbereich liegen, ist dies f\u00fcr\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    mit Resistenz gegen Cephalosporine der 3.\u00a0Generation und\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    mit Resistenz gegen Carbapeneme nicht der Fall und die Inzidenzen steigen an. Im EU-Vergleich liegt Deutschland bei den Inzidenzen im Mittelfeld.\n                  <\/jats:p>\n                  <jats:p>Neben Resistenzanteilen und Inzidenzen gibt das MICROBE-Projekt (Measuring Infectious Causes and Resistance Outcomes for Burden Estimation) absolute Anzahlen von Todesf\u00e4llen durch Krankheitsepisoden mit resistenten Erregern an. Es sterben pro Jahr \u00fcber 40.000 Menschen in Deutschland an Infektionen mit antibiotikaresistenten Erregern, bei fast 10.000 dieser F\u00e4lle ist die Resistenz der Erreger die Ursache. Damit sterben an solchen Infektionen deutlich mehr Menschen in Deutschland als an anderen Infektionskrankheiten.<\/jats:p>\n                  <jats:p>Die Auswirkungen auf das Gesundheitssystem sind erheblich, so f\u00fchrt die zunehmende Antibiotikaresistenz unter anderem zu einer erh\u00f6hten Krankheitslast bei h\u00e4matoonkologischen Krankheiten und Herausforderungen bei der perioperativen Antibiotikaprophylaxe.<\/jats:p>","DOI":"10.1007\/s00103-026-04234-6","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:19:43Z","timestamp":1777274383000},"page":"546-555","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Entwicklung der Epidemiologie antibiotikaresistenter Erreger in der Humanmedizin und deren Bedeutung f\u00fcr das Gesundheitssystem","Development of the epidemiology of antibiotic-resistant pathogens in human medicine and their significance for the health system in Germany"],"prefix":"10.1007","volume":"69","author":[{"given":"Tim","family":"Eckmanns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Feig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"4234_CR1","unstructured":"Bundesministerium f\u00fcr Gesundheit (2024) 1. 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