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Trotz der Zunahme an Kinderzulassungen durch die EU-Kinderarzneimittelverordnung werden Off-Label-Anwendungen weiterhin Teil der p\u00e4diatrischen Therapien bleiben. Die Online-Plattform \u201eKinderformularium.DE\u201c stellt seit 2021 evidenzbasierte Dosierungsempfehlungen f\u00fcr den On- und Off-Label-Bereich in Deutschland bereit und hat sich als feste Informationsquelle in der p\u00e4diatrischen Praxis etabliert. Ziel dieser Arbeit ist es, den Umfang und den Zulassungsstatus der enthaltenen altersspezifischen (Off-Label\u2011)Dosierungsempfehlungen zu analysieren und die Nutzung und Akzeptanz zu evaluieren.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methoden<\/jats:title>\n                    <jats:p>In den Wirkstoffmonographien wurden die Verf\u00fcgbarkeit und der Zulassungsstatus altersspezifischer Dosierungsempfehlungen unter Ber\u00fccksichtigung unterschiedlicher Indikationen und Applikationswege untersucht. Eine Nutzerumfrage (von 11\/2024 bis 02\/2025) wurde mittels Mixed-Methods-Analyse ausgewertet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Kinderformularium.DE enth\u00e4lt 637 Monographien mit 5536 spezifischen Dosierungsempfehlungen. Diese sind altersabh\u00e4ngig verteilt: F\u00fcr Fr\u00fch- und Neugeborene gibt es weniger Dosierungsinformationen, die zudem h\u00e4ufiger als off-label eingestuft sind. Die hohe Akzeptanz der Plattform, die vor allem von \u00c4rztinnen und \u00c4rzten h\u00e4ufig genutzt wird, best\u00e4tigt ihren Stellenwert in der p\u00e4diatrischen Versorgung.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Diskussion<\/jats:title>\n                    <jats:p>Mit seinen altersspezifischen (Off-Label\u2011)Dosierungsempfehlungen ist Kinderformularium.DE ein wichtiges Instrument zur F\u00f6rderung der Arzneimitteltherapiesicherheit in der p\u00e4diatrischen Versorgung in Deutschland. Die Plattform muss weiterhin kontinuierlich aktualisiert und erg\u00e4nzt werden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00103-026-04239-1","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:03:25Z","timestamp":1778490205000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evidenzbasierte Arzneimittelinformationen f\u00fcr Kinder und Jugendliche in Deutschland\u00a0\u2013 Sind wir auf dem richtigen Weg?","Evidence-based drug information for children and adolescents in Germany\u2014Are we moving in the right direction?"],"prefix":"10.1007","volume":"69","author":[{"given":"Ramona","family":"M\u00f6hrle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Eberl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Gramlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Haering-Zahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ahne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tjitske","family":"van der Zanden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"de Wildt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rascher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Neubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"4239_CR1","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1111\/bcp.12222","volume":"77","author":"JR Bellis","year":"2014","unstructured":"Bellis\u00a0JR, Kirkham\u00a0JJ, Nunn\u00a0AJ, Pirmohamed\u00a0M (2014) Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital. 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