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Die Pr\u00e4valenz einer Low-Response ist mit ca.\u00a020\u202f% h\u00e4ufig und ein Therapieregime wurde bisher noch nicht etabliert. Das Ziel dieser prospektiven Studie war es, die Effektivit\u00e4t eines Therapieschemas zur Therapieanpassung bei detektierter LR\/HPR bei gef\u00e4\u00dfchirurgischen Patienten zu evaluieren.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodik<\/jats:title>\n                    <jats:p>Insgesamt wurden 36\u00a0gef\u00e4\u00dfchirurgischen Patienten mit einer antithrombozyt\u00e4ren Dauermedikation mit ASS 100\u202fmg\/Tag und einer nachgewiesenen ASS-Low-Response (ALR) in die Studie eingeschlossen. Entsprechend dem festgelegten Therapieplan wurde bei diesen Patienten eine Therapieanpassung durchgef\u00fchrt und eine Kontrollaggregometrie zur Erfolgskontrolle durchgef\u00fchrt. Das verwendete Therapieschema folgte dem Test-and-treat-Prinzip. Zur Beurteilung der Wirkung von ASS diente die Impedanzaggregometrie mittels Mehrelektrodenaggregometer (Multiplate).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Insgesamt konnten alle 36\u00a0Patienten erfolgreich in eine Response \u00fcberf\u00fchrt werden. Bei 32 (88,89\u202f%) Patienten erfolgte eine Dosiserh\u00f6hung auf 300\u202fmg ASS, 2 (5,56\u202f%) Patienten wurden von ASS auf Clopidogrel umgestellt. Bei weiteren 2 (5,56\u202f%) Patienten wurde auf eine orale Antikoagulation mit Phenprocoumon aufgrund anderer Indikationen umgestellt. Blutungskomplikationen oder Nebenwirkungen traten nicht auf.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Das gew\u00e4hlte Therapieschema zur Behandlung einer Low-Response erwies sich als effektiv und sicher bei gef\u00e4\u00dfchirurgischen Patienten. \u00dcberwiegend f\u00fchrte eine leitliniengerechte Dosiserh\u00f6hung der Prophylaxe von 100\u202fmg auf 300\u202fmg ASS zu einer effektiven Thrombozytenaggregationshemmung in der Aggregometrie.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00104-020-01280-x","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T08:42:52Z","timestamp":1600418572000},"page":"640-646","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation einer Therapieanpassung bei ASS-Low-Response in der Gef\u00e4\u00dfchirurgie","Evaluation of treatment adaptation for low response to ASA in vascular surgery"],"prefix":"10.1007","volume":"92","author":[{"given":"T","family":"Hummel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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