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Die relativ geringe Inzidenz und Pr\u00e4valenz der Erkrankung, die uneinheitliche Dokumentation in den verschiedenen Studien sowie die notwendige Langzeitbeobachtung zur Erfassung therapeutischer Effekte erschwerten das Generieren valider Daten. Die Ver\u00f6ffentlichung des MGTX-Trials 2016 im <jats:italic>New England Journal of Medicine<\/jats:italic> lieferte die ersten randomisiert-kontrollierten Daten, nach denen Patienten mit Acetylcholin-Rezeptor-Antik\u00f6rper-positiver generalisierter Myasthenia gravis im Alter von 18 bis 65\u00a0Jahren von der chirurgischen Resektion des Thymus \u00fcber eine mediane Sternotomie profitieren. Trotz fehlender Validierung des Vorteils der Thymektomie \u00fcber minimal-invasive Techniken durch randomisiert-kontrollierte Studien scheinen diese das Outcome bestimmter Patientengruppen in \u00e4hnlicher Form positiv zu beeinflussen. So haben videoassistiert-thorakoskopische, roboterassistierte, subxiphoidale und transzervikale Zugangswege nicht nur \u00e4sthetische Vorteile, sondern zeigen in der Beeinflussung des Krankheitsverlaufs der Myasthenia gravis keine relevante Unterlegenheit gegen\u00fcber der medianen Sternotomie. Doch nicht nur der Nutzen und das \u00e4sthetische Ergebnis differieren, sondern auch die Erfolgsaussichten im Hinblick auf die Remission sind bei den Unterformen der Myasthenia gravis unterschiedlich. Die heterogene Gruppe der Myasthenien unterscheidet sich bez\u00fcglich des Auftretens von Autoantik\u00f6rpern, der betroffenen K\u00f6rperregionen und des Alters der Patienten bei Erstdiagnose. Schlie\u00dflich ist die Thymektomie eine wirksame kausale Therapie der Myasthenia gravis.<\/jats:p>","DOI":"10.1007\/s00104-021-01436-3","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T12:02:36Z","timestamp":1623844956000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Der Stellenwert der Thymektomie ohne Thymom in der Therapie der Myasthenia gravis","The value of thymectomy in the treatment of non-thymomatous myasthenia gravis"],"prefix":"10.1007","volume":"93","author":[{"given":"Hruy","family":"Menghesha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schroeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Doerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schlachtenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias B.","family":"Heldwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Chiapponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wahlers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Bruns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khosro","family":"Hekmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"1436_CR1","first-page":"529","volume":"189","author":"H Adler","year":"1937","unstructured":"Adler\u00a0H (1937) Thymus und myasthenie. 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