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Wie typisch f\u00fcr Pankreaskarzinome zeichnen sich periampull\u00e4re Pankreaskarzinome durch ein aggressives Wachstum und eine fr\u00fche systemische Progression aus. Aufgrund ihrer besonderen Lage in unmittelbarer N\u00e4he zur Papilla Vateri treten Symptome in eher fr\u00fcherem Tumorstadium auf, sodass die Therapiem\u00f6glichkeiten und Prognose insgesamt g\u00fcnstiger sind als bei Pankreaskarzinomen anderer Lokalisation. Trotzdem unterscheiden sich die Therapieprinzipien bei periampull\u00e4ren Pankreaskarzinomen nicht wesentlich von den Standards bei Pankreaskarzinomen anderer Lokalisation. Ein potenziell kurativer Therapieansatz beim nichtmetastasierten periampull\u00e4ren Pankreaskarzinom ist multimodal und besteht aus der Durchf\u00fchrung einer partiellen Duodenopankreatektomie als radikale onkologische Resektion in Kombination mit einer systemischen, meist adjuvant verabreichten Chemotherapie. Bei Patienten mit g\u00fcnstigen prognostischen Faktoren kann hierdurch ein Langzeit\u00fcberleben erzielt werden. Zudem wurden mit der Weiterentwicklung der Chirurgie und Systemtherapie auch potenziell kurative Therapiekonzepte f\u00fcr fortgeschrittene, fr\u00fcher irresektable Tumoren etabliert, welche nun nach Durchf\u00fchrung einer neoadjuvanten Therapie oft einer Resektion zugef\u00fchrt werden k\u00f6nnen. In diesem Beitrag werden die aktuellen chirurgischen Prinzipien der radikalen onkologischen Resektion periampull\u00e4rer Pankreaskarzinome im Kontext der multimodalen Therapie dargestellt und ein Ausblick auf m\u00f6gliche k\u00fcnftige Entwicklungen der Therapie gegeben.<\/jats:p>","DOI":"10.1007\/s00104-021-01462-1","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T12:03:54Z","timestamp":1626264234000},"page":"776-787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chirurgie periampull\u00e4rer Pankreaskarzinome","Surgery for periampullary pancreatic cancer"],"prefix":"10.1007","volume":"92","author":[{"given":"Thomas","family":"Hank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Klaiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Sahora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schindl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Strobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"1462_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S0039-6109(05)70142-0","volume":"81","author":"JM Sarmiento","year":"2001","unstructured":"Sarmiento\u00a0JM, Nagomey\u00a0DM, Sarr\u00a0MG, Farnell\u00a0MB (2001) Periampullary cancers: are there differences? 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