{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:44:16Z","timestamp":1740185056426,"version":"3.37.3"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005296","name":"Universit\u00e4tsklinikum Regensburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005296","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chirurgie"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Trotz steigender Inzidenz ist die optimale chirurgische Versorgung des Adenokarzinoms des \u00f6sophagogastralen \u00dcbergangs (AEG) Typ\u00a0II weiterhin Gegenstand aktueller Forschung. Ziel dieser Untersuchung ist es, \u00dcberlebens- und Rezidivraten von Patienten zu vergleichen, die sich entweder einer transhiatal erweiterten Gastrektomie (TEG) oder einer thorakoabdominellen \u00d6sophagektomie (TAE) unterzogen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Es handelt es sich um eine retrospektive populationsbasierte Kohortenstudie (<jats:italic>n<\/jats:italic>\u202f=\u2009272) auf der Basis von Krebsregisterdaten. Ber\u00fccksichtigt wurden alle Patienten, die zwischen 2002 und 2020 an einem AEG Typ\u00a0II erkrankten. W\u00e4hrend 63\u00a0Patienten mittels TAE operiert wurden, geh\u00f6ren der Gruppe der TEG 209\u00a0Patienten an. Um das Gesamt\u00fcberleben, Rezidivraten und rezidivfreies \u00dcberleben zu untersuchen, wurden die Kaplan-Meier-Methode sowie uni- und multivariable Cox-Regressionen angewendet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>Zwischen beiden Operationsgruppen gab es bez\u00fcglich des Gesamt\u00fcberlebens keinen signifikanten Unterschied (<jats:italic>p<\/jats:italic>\u202f=\u20090,333). Allerdings lie\u00df die Richtung der HR im Zeitraum von 2016 bis 2020 eine m\u00f6gliche Tendenz in Richtung der TAE erkennen (<jats:italic>p<\/jats:italic>\u202f=\u20090,058). Im Gegensatz dazu ergab der Kaplan-Meier-Sch\u00e4tzer ein signifikant h\u00f6heres Risiko, nach einer TAE an einem Rezidiv zu erkranken (<jats:italic>p<\/jats:italic>\u202f=\u20090,049). Dies konnte nicht im Zeitraum 2016 bis 2020, der mehr als die H\u00e4lfte der TAE-Patienten umfasst, beobachtet werden (<jats:italic>p<\/jats:italic>\u202f=\u20090,993). Hinsichtlich des rezidivfreien \u00dcberlebens wurden keine signifikanten Unterschiede detektiert (<jats:italic>p<\/jats:italic>\u202f=\u20090,772).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Die Ergebnisse dieser verh\u00e4ltnism\u00e4\u00dfig kleinen Kohorte decken sich mit den meisten Studien, die hinsichtlich des Gesamt\u00fcberlebens entweder keine Unterschiede oder eine Tendenz in Richtung der TAE fanden. Weitere Arbeiten kamen ebenfalls zu dem Ergebnis, dass es keine signifikanten Unterschiede zwischen den beiden Operationsgruppen bez\u00fcglich des rezidivfreien \u00dcberlebens gibt. Zusammenfassend l\u00e4sst sich festhalten, dass es keine signifikanten Unterschiede zwischen TEG und TAE in der Therapie des AEG Typ\u00a0II gibt.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00104-022-01703-x","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T18:02:43Z","timestamp":1661018563000},"page":"1072-1081","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chirurgische Therapie des Adenokarzinoms des \u00f6sophagogastralen \u00dcbergangs Typ\u00a0II","Surgical treatment of adenocarcinoma of the esophagogastric junction type II"],"prefix":"10.1007","volume":"93","author":[{"given":"Roman","family":"St\u00fcrzl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gerken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Bruns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Klinkhammer-Schalke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Pauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pompiliu","family":"Piso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"1703_CR1","first-page":"6","volume-title":"Krebs in Deutschland f\u00fcr 2017\/2018. 13. Ausgabe","author":"Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.\u202fV.","year":"2021","unstructured":"Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.\u202fV. (2021) Krebs in Deutschland f\u00fcr 2017\/2018. 13. Ausgabe Bd. 40. Robert Koch-Institut, Gesellschaft der epidemiologischen Krebsregister in Deutschland e.\u202fV., Berlin, S 6\u20139"},{"issue":"1","key":"1703_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.semradonc.2012.09.008","volume":"23","author":"MF Buas","year":"2013","unstructured":"Buas\u00a0MF, Vaughan\u00a0TL (2013) Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease. Semin Radiat Oncol 23(1):3\u20139","journal-title":"Semin Radiat Oncol"},{"key":"1703_CR3","first-page":"25","volume":"58","author":"JR Siewert","year":"1987","unstructured":"Siewert\u00a0JR, H\u00f6lscher\u00a0AH, Becker\u00a0K, G\u00f6ssner\u00a0W (1987) Cardia cancer: attempt at a\u00a0therapeutically relevant classification. Chirurg 58:25\u201332","journal-title":"Chirurg"},{"key":"1703_CR4","first-page":"7","volume":"29","author":"J Werner","year":"2013","unstructured":"Werner\u00a0J, Sauer\u00a0P (2013) Nahtinsuffizienz intestinaler Anastomosen: Endoskopische und laparoskopische Therapieoptionen. Viszeralmedizin 29:7\u201313","journal-title":"Viszeralmedizin"},{"issue":"2","key":"1703_CR5","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/(SICI)1098-2388(199909)17:2<125::AID-SSU7>3.0.CO;2-9","volume":"17","author":"JR Siewert","year":"1999","unstructured":"Siewert\u00a0JR, Stein\u00a0HJ, Sendler\u00a0A, Fink\u00a0U (1999) Surgical resection for cancer of the cardia. Semin Surg Oncol 17(2):125\u2013131","journal-title":"Semin Surg Oncol"},{"key":"1703_CR6","volume-title":"General thoracic surgery","author":"TW Shields","year":"2011","unstructured":"Shields\u00a0TW, LoCicero\u00a0J, Reed\u00a0CE, Feins\u00a0RH (2011) General thoracic surgery. Wolters Kluwer (E-Book)"},{"key":"1703_CR7","unstructured":"Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, Deutsche Krebshilfe, AWMF): S3-Leitlinie Diagnostik und Therapie der Plattenepithelkarzinome und Adenokarzinome des \u00d6sophagus, Langversion 3.0, Oktober 2021, 82, AWMF Registernummer: 021\/023OL https:\/\/www.leitlinienprogramm-onkologie.de\/leitlinien\/oesophaguskarzinom\/ (abgerufen am: 27. Apr. 2022)"},{"issue":"1","key":"1703_CR8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00423-018-1745-3","volume":"404","author":"P Heger","year":"2019","unstructured":"Heger\u00a0P, Blank\u00a0S, Goo\u00dfen\u00a0K, Nienh\u00fcser\u00a0H, Diener\u00a0MK, Ulrich\u00a0A, Mihaljevic\u00a0AL, Schmidt\u00a0T (2019) Thoracoabdominal versus transhiatal surgical approaches for Adenokarzinoma of the esophagogastric junction\u2014a systematic review and meta-analysis. Langenbecks Arch Surg 404(1):103\u2013113","journal-title":"Langenbecks Arch Surg"},{"issue":"44","key":"1703_CR9","first-page":"739","volume":"116","author":"P Baum","year":"2019","unstructured":"Baum\u00a0P, Diers\u00a0J, Lichthardt\u00a0S, Kastner\u00a0C, Schlegel\u00a0N, Germer\u00a0CT, Wiegering\u00a0A (2019) Mortality and complications following visceral surgery: a nationwide analysis based on the diagnostic categories used in German hospital invoicing data. Dtsch Arztebl Int 116(44):739\u2013746","journal-title":"Dtsch Arztebl Int"},{"issue":"8","key":"1703_CR10","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/S1470-2045(06)70766-5","volume":"7","author":"M Sasako","year":"2006","unstructured":"Sasako\u00a0M, Sano\u00a0T, Yamamoto\u00a0S, Sairenji\u00a0M, Arai\u00a0K, Kinoshita\u00a0T, Nashimoto\u00a0A, Hiratsuka\u00a0M, Japan Clinical Oncology Group (JCOG9502) (2006) Left thoracoabdominal approach versus abdominal-transhiatal approach for gastric cancer of the cardia or subcardia: a\u00a0randomised controlled trial. Lancet Oncol 7(8):644\u2013651","journal-title":"Lancet Oncol"},{"issue":"3","key":"1703_CR11","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/00000658-200009000-00007","volume":"232","author":"RJ Siewert","year":"2000","unstructured":"Siewert\u00a0RJ et\u00a0al (2000) Adenokarzinoma of the esophagogastric junction: results of surgical therapy based on anatomical\/topographic classification in 1,002\u00a0consecutive patients. Ann Surg 232(3):353\u2013361","journal-title":"Ann Surg"},{"issue":"1","key":"1703_CR12","doi-asserted-by":"publisher","first-page":"17783","DOI":"10.1038\/s41598-017-18005-6","volume":"7","author":"JH Kauppila","year":"2017","unstructured":"Kauppila\u00a0JH, Wahlin\u00a0K, Lagergren\u00a0J (2017) Gastrectomy compared to oesophagectomy for Siewert II and III gastro-oesophageal junctional cancer in relation to resection margins, lymphadenectomy and survival. Sci Rep 7(1):17783","journal-title":"Sci Rep"},{"key":"1703_CR13","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1245\/s10434-014-4047-1","volume":"22","author":"K Parry","year":"2014","unstructured":"Parry\u00a0K, Haverkamp\u00a0L, Bruijnen\u00a0RCG, Siersema\u00a0PD, Ruurda\u00a0JP, van Hillegersberg\u00a0R (2014) Surgical treatment of Adenokarzinomas of the gastro-esophageal junction. Ann Surg Oncol 22:597\u2013603","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"1703_CR14","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s10120-017-0746-1","volume":"21","author":"S Blank","year":"2018","unstructured":"Blank\u00a0S, Schmidt\u00a0T, Heger\u00a0P, Strowitzki\u00a0MJ, Sisic\u00a0L, Heger\u00a0U, Nienhueser\u00a0H, Haag\u00a0GM, Bruckner\u00a0T, Mihaljevic\u00a0AL, Ott\u00a0K, B\u00fcchler\u00a0MW, Ulrich\u00a0A (2018) Surgical strategies in true Adenokarzinoma of the esophagogastric junction (AEG II): thoracoabdominal or abdominal approach? Gastric Cancer 21(2):303\u2013314","journal-title":"Gastric Cancer"},{"issue":"5","key":"1703_CR15","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1442-2050.2008.00923.x","volume":"22","author":"G Schumacher","year":"2009","unstructured":"Schumacher\u00a0G, Schmidt\u00a0SC, Schlechtweg\u00a0N, Roesch\u00a0T, Sacchi\u00a0M, von Dossow\u00a0V, Chopra\u00a0SS, Pratschke\u00a0J, Zhukova\u00a0J, Stieler\u00a0J, ThussPatience\u00a0P, Neuhaus\u00a0P (2009) Surgical results of patients after esophageal resection or extended gastrectomy for cancer of the esophagogastric junction. Dis Esophagus 22(5):422\u2013426","journal-title":"Dis Esophagus"},{"key":"1703_CR16","unstructured":"AOK-Bundesvorstand Operationen und Prozedurenschl\u00fcssel Version 2021. www.aok-bv.de. https:\/\/www.aok-bv.de\/imperia\/md\/aokbv\/engagement\/mindestmengen\/operationen-_und_prozedurenschluessel_2022.pdf (Erstellt: 17. Juni 2021). Zugegriffen: 17. Febr. 2022"},{"issue":"4","key":"1703_CR17","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.ejso.2021.11.121","volume":"48","author":"PC van der Sluis","year":"2022","unstructured":"van der Sluis\u00a0PC, Babic\u00a0B, Uzun\u00a0E, Tagkalos\u00a0E, Berlth\u00a0F, Hadzijusufovic\u00a0E, Lang\u00a0H, Gockel\u00a0I, van Hillegersberg\u00a0R, Grimminger\u00a0PP (2022) Robot-assisted and conventional minimally invasive esophagectomy are associated with better postoperative results compared to hybrid and open transthoracic esophagectomy. Eur J Surg Oncol 48(4):776\u2013782","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"1703_CR18","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1186\/s12885-020-07152-1","volume":"20","author":"JM Leers","year":"2020","unstructured":"Leers\u00a0JM, Knepper\u00a0L, van der Veen\u00a0A et al (2020) The CARDIA-trial protocol: a\u00a0multinational, prospective, randomized, clinical trial comparing transthoracic esophagectomy with transhiatal extended gastrectomy in adenocarcinoma of the gastroesophageal junction (GEJ) type II. BMC Cancer 20(1):781. https:\/\/doi.org\/10.1186\/s12885-020-07152-1","journal-title":"BMC Cancer"}],"container-title":["Die Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00104-022-01703-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00104-022-01703-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00104-022-01703-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T15:03:05Z","timestamp":1666623785000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00104-022-01703-x"}},"subtitle":["Vergleich zwischen transhiatal erweiterter Gastrektomie und thorakoabdomineller \u00d6sophagektomie","Comparison between transhiatal extended gastrectomy and thoracoabdominal esophagectomy"],"short-title":[],"issued":{"date-parts":[[2022,8,20]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["1703"],"URL":"https:\/\/doi.org\/10.1007\/s00104-022-01703-x","relation":{},"ISSN":["2731-6971","2731-698X"],"issn-type":[{"type":"print","value":"2731-6971"},{"type":"electronic","value":"2731-698X"}],"subject":[],"published":{"date-parts":[[2022,8,20]]},"assertion":[{"value":"28 July 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"R.\u00a0St\u00fcrzl, M.\u00a0Gerken, C.\u00a0Bruns, M.\u00a0Klinkhammer-Schalke, A.\u00a0Pauer und P.\u00a0Piso geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}