{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:25:27Z","timestamp":1788881127494,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chirurgie"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n                <jats:title>Hintergrund<\/jats:title>\n                <jats:p>Das Ph\u00e4ochromozytom ist eine seltene, aber schwerwiegende Erkrankung der Nebennieren. Ziel dieser Arbeit ist die Darstellung und Diskussion aktueller Entwicklungen zum diagnostischen und therapeutischen Vorgehen beim Ph\u00e4ochromozytom.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material und Methoden<\/jats:title>\n                <jats:p>Es wurde ein narrativer \u00dcbersichtsartikel auf Basis der aktuellsten Literatur erstellt.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse und Diskussion<\/jats:title>\n                <jats:p>Der Anteil von Ph\u00e4ochromozytomen als Tumoren adrenalen Ursprungs liegt bei etwa 5\u202f% der zuf\u00e4llig entdeckten Nebennierentumoren. Die klassische symptomatische Triade aus Kopfschmerzen, Schwitzen und Palpitationen tritt nur bei etwa 20\u202f% der Patientinnen und Patienten auf, w\u00e4hrend fast alle Patientinnen und Patienten mindestens eines dieser Symptome aufweisen. Die Diagnostik umfasst im ersten Schritt den biochemischen Nachweis der freien Plasmametanephrine oder alternativ fraktionierter Metanephrine im 24-h-Sammelurin. Erst im zweiten Schritt erfolgt ein Schnittbildverfahren (Computer- oder Magnetresonanztomographie) zur Lokalisationsdiagnostik. Eine funktionelle Bildgebung ist ebenfalls sinnvoll, um eine Metastasierung pr\u00e4operativ zu erkennen. Eine genetische Testung sollte immer im Verlauf der Behandlung angeboten werden, da 30\u201340\u202f% der Ph\u00e4ochromozytome mit genetischen Ver\u00e4nderungen assoziiert sind. Das Dogma der pr\u00e4operativen \u03b1\u2011Blockade wird durch aktuelle Daten zunehmend infrage gestellt und in den letzten Jahren kontrovers diskutiert. Die minimal-invasive Entfernung des Nebennierentumors ist Standard, wobei transabdominelle und retroperitoneoskopische laparoskopische Verfahren als gleichwertig anzusehen sind. Die Wahl des minimal-invasiven Verfahrens h\u00e4ngt von der Expertise und Erfahrung des Operateurs\/der Operateurin ab und sollte in erster Linie daran angepasst werden. Postoperativ ist eine individualisierte und regelm\u00e4\u00dfige Nachsorge wichtig.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00104-023-01988-6","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T17:02:49Z","timestamp":1699894969000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Personalisierte Therapie des Ph\u00e4ochromozytoms","Personalized treatment of pheochromocytoma"],"prefix":"10.1007","volume":"95","author":[{"given":"Nicolas","family":"Schlegel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Meir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Reibetanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Wiegering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"issue":"2","key":"1988_CR1","doi-asserted-by":"publisher","first-page":"bvac004","DOI":"10.1210\/jendso\/bvac004","volume":"6","author":"GFC Fagundes","year":"2022","unstructured":"Fagundes\u00a0GFC, Almeida\u00a0MQ (2022) Perioperative management of pheochromocytomas and sympathetic paragangliomas. 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