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Die PD ist auch bei benignen Neoplasien mit dem Risiko erheblicher Komplikationen in der fr\u00fchen postoperativen Phase assoziiert und geht mit einer Krankenhausmortalit\u00e4t von bis zu 5\u202f% einher. Nach Whipple-Operation wird bei 14\u201320\u202f% der Patienten ein sich neu manifestierender Diabetes mellitus beobachtet, bei 25\u201345\u202f% tritt eine exokrine Insuffizienz auf, was zu einer nach Resektion benigner Tumoren persistierenden metabolischen Dysfunktion und Beeintr\u00e4chtigung der Lebensqualit\u00e4t f\u00fchrt. Symptomatische Neoplasien sind Indikation f\u00fcr die operative Therapie. Patienten mit asymptomatischen Pankreastumoren werden gem\u00e4\u00df den Kriterien von Surveillance-Protokollen behandelt. Ziel der operativen Therapie bei asymptomatischen Patienten ist entsprechend den Leitlinienkriterien der Abbruch des Surveillance-Programms, bevor sich eine fortgeschrittene Krebserkrankung im Zusammenhang mit der Neoplasie entwickelt. Die Tumorenukleation und duodenumerhaltende Pankreaskopfresektion, entweder total oder partiell, sind parenchymsparende Resektionen bei benignen Neoplasien des Pankreaskopfs. Erste Wahl bei kleinen Tumoren ist die Enukleation; allerdings ist diese mit einem erh\u00f6hten Risiko f\u00fcr Pankreasfisteln von Grad\u00a0B\u202f+\u2009C nach Pankreas-Hauptgangverletzung assoziiert. Vorteile der duodenumerhaltenden totalen oder partiellen Pankreaskopfresektion sind geringe operationsbedingte Komplikationen, eine\u00a0Mortalit\u00e4t von &lt;\u202f0,5\u202f% und die Aufrechterhaltung der endo- und exokrinen Pankreasfunktionen. Parenchymsparende Pankreaskopfresektionen sollten die klassischen Whipple-Operationen bei Neoplasien des Pankreaskopfs abl\u00f6sen.<\/jats:p>","DOI":"10.1007\/s00104-024-02070-5","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:02:07Z","timestamp":1712124127000},"page":"461-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pr\u00e4maligne, zystische Neoplasien und neuroendokrine Tumoren des Pankreaskopfes\u00a0\u2013 Ist die Kausch-Whipple-Resektion eine ad\u00e4quate Therapie?","Premalignant cystic neoplasms and neuroendocrine tumors of the pancreatic head\u2014Is the Kausch-Whipple resection an adequate treatment?"],"prefix":"10.1007","volume":"95","author":[{"given":"Hans G.","family":"Beger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"issue":"3","key":"2070_CR1","doi-asserted-by":"publisher","first-page":"e325","DOI":"10.1097\/AS9.0000000000000325","volume":"4","author":"HG Beger","year":"2023","unstructured":"Beger\u00a0HG, Friess\u00a0H, Uhl\u00a0W (2023) Whipple resection for genign tumors and premalignant neoplasms of the pancreatic head. 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