{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:35:30Z","timestamp":1758818130836},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1007\/s00105-006-1171-2","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T12:37:08Z","timestamp":1150202228000},"page":"576-585","source":"Crossref","is-referenced-by-count":2,"title":["Atopische Dermatitis: Hygiene-Hypothese","Atopic dermatitis: The hygiene hypothesis"],"prefix":"10.1007","volume":"57","author":[{"given":"A.","family":"Heratizadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Werfel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"1171_CR1","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0140-6736(98)09344-1","volume":"353","author":"Alm","year":"1999","unstructured":"Alm SJ, Swartz J, Lilja G et al. (1999) Atopy in children of families with an anthroposophic lifestyle. Lancet 353: 1485\u20131488","journal-title":"Lancet"},{"key":"1171_CR2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1183\/09031936.98.12020315","volume":"12","author":"Asher","year":"1998","unstructured":"Asher MI, Anderson HR, Stewart AW, Crane J (1998) Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC). Eur Respir J 12: 315\u2013335","journal-title":"Eur Respir J"},{"key":"1171_CR3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","volume":"347","author":"Bach","year":"2002","unstructured":"Bach JF (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347: 911\u2013920","journal-title":"N Engl J Med"},{"key":"1171_CR4","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.4049\/jimmunol.169.6.3284","volume":"169","author":"Bashir","year":"2002","unstructured":"Bashir MEH, Andersen P, Fuss IJ et al. (2002) An enteric helminth infection protects against an allergic response to dietary antigen. J Immunol 169: 3284\u20133292","journal-title":"J Immunol"},{"key":"1171_CR5","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(97)07302-9","volume":"351","author":"Beasley","year":"1998","unstructured":"Beasley R, Keil U, von Mutius E, Pearce N (1998) Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 351: 1225\u20131232","journal-title":"Lancet"},{"key":"1171_CR6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1067\/mai.2003.1348","volume":"111","author":"Cooper","year":"2003","unstructured":"Cooper PJ, Chico ME, Rodrigues LC et al. (2003) Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol 111: 995\u20131000","journal-title":"J Allergy Clin Immunol"},{"key":"1171_CR7","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1086\/515661","volume":"178","author":"Cooper","year":"1998","unstructured":"Cooper PJ, Espinel I, Paredes W et al. (1998) Impaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: A possible role for interleukin-10. J Inf Dis 178: 1133\u20131138","journal-title":"J Inf Dis"},{"key":"1171_CR8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0091-6749(98)70129-0","volume":"102","author":"Dold","year":"1998","unstructured":"Dold S, Heinrich J, Wichmann HE, Wjst M (1998) Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany. J Allergy Clin Immunol 102: 414\u2013420","journal-title":"J Allergy Clin Immunol"},{"key":"1171_CR9","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1046\/j.1365-2222.2000.00939.x","volume":"30","author":"Droste","year":"2000","unstructured":"Droste JHJ, Wieringa MH, Weyler J et al. (2000) Does the use of antibiotics in early childhood increase the risk of asthma and allergic disease? Clin Exp Allergy 30: 1547\u20131553","journal-title":"Clin Exp Allergy"},{"key":"1171_CR10","unstructured":"Eckert J (1998) Helminthen als Krankheitserreger. In: Kayser FH, Bienz KA, Eckert J, Zinkernagel RM (Hrsg) Medizinische Mikrobiologie. Thieme, Stuttgart New York, S 557\u2013620"},{"key":"1171_CR11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1136\/thx.53.11.927","volume":"53","author":"Farooqi","year":"1998","unstructured":"Farooqi IS, Hopkin JM (1998) Early childhood infection and atopic disorder. Thorax 53: 927\u2013932","journal-title":"Thorax"},{"key":"1171_CR12","doi-asserted-by":"crossref","unstructured":"Flohr C (2003) Dirt, worms and atopic dermatitis, Br J Dermatol 148: 871\u2013877","DOI":"10.1046\/j.1365-2133.2003.05403.x"},{"key":"1171_CR13","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1046\/j.1365-2745.2002.01424.x","volume":"32","author":"Huang","year":"2002","unstructured":"Huang SL, Tsai PF, Yeh YF (2002) Negative association of the Enterobius infestation with asthma and rhinitis in primary school children in Taipei. Clin Exp Allergy 32: 1029\u20131032","journal-title":"Clin Exp Allergy"},{"key":"1171_CR14","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0140-6736(03)13490-3","volume":"361","author":"Kalliom","year":"2003","unstructured":"Kalliom\u00e4ki M, Salminen S, Poussa T et al. (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361: 1869\u20131871","journal-title":"Lancet"},{"key":"1171_CR15","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.4049\/jimmunol.150.5.1873","volume":"150","author":"King","year":"1993","unstructured":"King CL, Low CC, Nutman TB (1993) IgE production in human helminth infection. J Immunol 150: 1873\u20131880","journal-title":"J Immunol"},{"key":"1171_CR16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0091-6749(98)70386-0","volume":"101","author":"Lynch","year":"1998","unstructured":"Lynch NR, Hagel IA, Palenque ME et al. (1998) Relationship between helminthic infection and IgE response in atopic and nonatopic children in a tropical environment. J Allergy Clin Immunol 101: 217\u2013221","journal-title":"J Allergy Clin Immunol"},{"key":"1171_CR17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1136\/bmj.320.7232.412","volume":"320","author":"Matricardi","year":"2000","unstructured":"Matricardi PM, Rosmini F, Riondino S et al. (2000) Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 320: 412\u2013417","journal-title":"BMJ"},{"key":"1171_CR18","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1067\/mpd.2002.122937","volume":"140","author":"Perzanowski","year":"2002","unstructured":"Perzanowski MS, Ng\u2019ang\u2019a LW, Carter MC et al. (2002) Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya. J Pediatr 140: 582\u2013588","journal-title":"J Pediatr"},{"key":"1171_CR19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/jrnms-56-229","volume":"56","author":"Preston","year":"1970","unstructured":"Preston PJ (1970) The biology of the atopic response. J Roy Nav Med Ser 56: 229\u2013235","journal-title":"J Roy Nav Med Ser"},{"key":"1171_CR20","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1046\/j.1365-2133.2000.03832.x","volume":"143","author":"Sch","year":"2000","unstructured":"Sch\u00e4fer T, Kr\u00e4mer U, Vieluf D et al. (2000) The excess of atopic eczema in East Germany is related to the intrinsic type. Br J Dermatol 143: 992\u2013998","journal-title":"Br J Dermatol"},{"key":"1171_CR21","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1398-9995.2005.00801.x","volume":"60","author":"Sch","year":"2005","unstructured":"Sch\u00e4fer T, Meyer T, Ring J et al. (2005) Worm infestation and the negative association with eczema (atopic\/nonatopic) and allergic sensitization. Allergy 60: 1014\u20131020","journal-title":"Allergy"},{"key":"1171_CR22","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","volume":"299","author":"Strachan","year":"1989","unstructured":"Strachan DP (1989) Hay fever, hygiene and household size. BMJ 299: 1259\u20131260","journal-title":"BMJ"},{"key":"1171_CR23","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1086\/381767","volume":"189","author":"Van","year":"2004","unstructured":"Van den Biggelaar AHJ, Rodrigues LC, Van Ree R et al. (2004) Long-term treatment of intestinal helminths increases mite skin-test reactivity in Gabonese schoolchildren. JID 189: 892\u2013900","journal-title":"JID"},{"key":"1171_CR24","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(00)03206-2","volume":"356","author":"Van","year":"2000","unstructured":"Van den Biggelaar AHJ, Van Ree R, Rodrigues LC et al. (2000) Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 356: 1723\u20131727","journal-title":"Lancet"},{"key":"1171_CR25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2222.2000.00801.x","volume":"30","author":"Von","year":"2000","unstructured":"Von Ehrenstein OS, Von Mutius E, Illi S et al. (2000) Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 30: 187\u2013193","journal-title":"Clin Exp Allergy"},{"key":"1171_CR26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0091-6749(99)70536-1","volume":"103","author":"Williams","year":"1999","unstructured":"Williams H, Robertson C, Stewart A et al. (1999) Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. J Allergy Clin Immunol 103: 125\u2013138","journal-title":"J Allergy Clin Immunol"},{"key":"1171_CR27","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1126\/science.296.5567.490","volume":"296","author":"Yazdanbakhsh","year":"2002","unstructured":"Yazdanbakhsh M, Kremser PG, Van Ree R (2002) Allergy, parasites, and the hygiene hypothesis. Science 296: 490\u2013494","journal-title":"Science"},{"key":"1171_CR28","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1365-2222.2005.02350.x","volume":"35","author":"Zutavern","year":"2005","unstructured":"Zutavern A, Hirsch T, Leupold W et al. (2005). Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis: results from a cross-sectional study. Clin Exp Allergy 35: 1301\u20131308","journal-title":"Clin Exp Allergy"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-006-1171-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00105-006-1171-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-006-1171-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T18:21:27Z","timestamp":1683483687000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00105-006-1171-2"}},"subtitle":["Pr\u00e4vention durch Helmintheninfektionen?","Prevention through helminth infections?"],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["1171"],"URL":"https:\/\/doi.org\/10.1007\/s00105-006-1171-2","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"value":"0017-8470","type":"print"},{"value":"1432-1173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}