{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:48:16Z","timestamp":1760384896429},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T00:00:00Z","timestamp":1224633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1007\/s00105-008-1591-2","type":"journal-article","created":{"date-parts":[[2008,10,20]],"date-time":"2008-10-20T10:33:23Z","timestamp":1224498803000},"page":"893-903","source":"Crossref","is-referenced-by-count":8,"title":["Genetische Ursachen schwerer Wundheilungsst\u00f6rungen","Genetic causes of impaired wound healing"],"prefix":"10.1007","volume":"59","author":[{"given":"K.","family":"Elsharkawi-Welt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hepp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Scharffetter-Kochanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,10,22]]},"reference":[{"key":"1591_CR1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.it.2003.08.001","volume":"24","author":"Alon","year":"2003","unstructured":"Alon R, Etzioni A (2003) LAD-III, a novel group of leukocyte integrin activation deficiencies. Trends Immunol 24: 561\u2013566","journal-title":"Trends Immunol"},{"key":"1591_CR2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.me.38.020187.001135","volume":"38","author":"Anderson","year":"1987","unstructured":"Anderson DC, Springer TA (1987) Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 38: 175\u2013194","journal-title":"Annu Rev Med"},{"key":"1591_CR3","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2165\/00003495-200262080-00003","volume":"62","author":"Ballas","year":"2002","unstructured":"Ballas SK (2002) Sickle cell anaemia: progress in pathogenesis and treatment. Drugs 62: 1143\u20131172","journal-title":"Drugs"},{"key":"1591_CR4","unstructured":"Becker PS, Lux SE (1993) Disorders of the red cell membrane. In: Nathan O (ed) Hematology of infancy and childhood. WB Sanders, Philadelphia"},{"key":"1591_CR5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1072-7515(98)00196-3","volume":"187","author":"Cackovic","year":"1998","unstructured":"Cackovic M, Chung C, Bolton LL, Kerstein MD (1998) Leg ulceration in the sickle cell patient. J Am Coll Surg 187(3): 307\u2013309","journal-title":"J Am Coll Surg"},{"key":"1591_CR6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1399-0004.1981.tb00709.x","volume":"19","author":"Campbell","year":"1981","unstructured":"Campbell WA, Price W (1981) Venous thromboembolic disease in Klinefelter\u2019s syndrome. Clin Genet 19: 275\u2013280","journal-title":"Clin Genet"},{"key":"1591_CR7","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/0026-0495(89)90014-0","volume":"38","author":"Caron","year":"1989","unstructured":"Caron P, Bennet A, Camare R et al (1989) Plasminogen activator inhibitor in plasma is related to testoterone in men. Metabolism 38: 1010\u20131015","journal-title":"Metabolism"},{"key":"1591_CR8","first-page":"240","volume":"19","author":"Dissemond","year":"2005","unstructured":"Dissemond J, Knab J, Lehnen M, Goos M (2005) Increased activity of factor VIII coagulant associated with venous ulcer in a patient with Klinefelters\u2019s syndrome. JEADV 19: 240\u2013242","journal-title":"JEADV"},{"key":"1591_CR9","first-page":"516","volume":"13","author":"Egeborg","year":"1965","unstructured":"Egeborg O (1965) Inherited antithrombin deficiency causing thrombophilia. Thromb Diathesis Haemorrhage 13: 516\u2013530","journal-title":"Thromb Diathesis Haemorrhage"},{"key":"1591_CR10","first-page":"375","volume":"29","author":"Frost","year":"1990","unstructured":"Frost ML, Treadwell P (1990) Treatment of sickle cell leg ulcers with pentoxifylline. In J Dermatol 29: 375\u2013376","journal-title":"In J Dermatol"},{"key":"1591_CR11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1365-2249.2000.01264.x","volume":"121","author":"Gadola","year":"2000","unstructured":"Gadola SD, Moins-Teisserenc HT, Trowsdale J et al. (2000) Tap deficiency syndrome. Clin Exp Immunol 121: 173\u2013178","journal-title":"Clin Exp Immunol"},{"key":"1591_CR12","first-page":"254","volume":"25","author":"Gallenkemper","year":"1996","unstructured":"Gallenkemper G, Bulling BJ, Kahle B et al. (1996) Leitlinie zur Diagnostik und Therapie des Ulcus cruris venosum. Phlebol 25: 254\u2013258","journal-title":"Phlebol"},{"key":"1591_CR13","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1172\/JCI110385","volume":"68","author":"Griffin","year":"1981","unstructured":"Griffin JH, Evatt B, Zimmermann TS et al. (1981) Deficiency of protein C in congenital thrombotic disease. J Clin Invest 68: 1370\u20131373","journal-title":"J Clin Invest"},{"key":"1591_CR14","doi-asserted-by":"crossref","unstructured":"Gromme M, Neefjes J (2002) Antigen degradation or presentation by MHC class I molecules via classical and non-classical pathways. Mol Immunol. 39(3\u20134): 181\u2013202","DOI":"10.1016\/S0161-5890(02)00101-3"},{"key":"1591_CR15","first-page":"431","volume":"15","author":"Gruble","year":"1996","unstructured":"Gruble N, Stegnar M, Peternel P et al. (1996) A novel G\/A and the 4G\/5G-polymorphism within the promoter of the plasminogen activator inhibitor-1 gene in patients with deep vein thrombosis. Thromb Res 15(84): 431\u2013443","journal-title":"Thromb Res"},{"key":"1591_CR16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-2141.2003.03849.x","volume":"120","author":"Halsey","year":"2003","unstructured":"Halsey C, Roberts IA (2003) The role of Hydroxyurea in sickle cell disease. Br J Haematol 120: 177\u2013186","journal-title":"Br J Haematol"},{"key":"1591_CR17","doi-asserted-by":"crossref","first-page":"1285S","DOI":"10.1093\/jn\/126.suppl_4.1285S","volume":"126","author":"Harpel","year":"1996","unstructured":"Harpel PC, Zhang X, Borth W (1996) Homocysteine and hemostasis: pathogenic mechanisms predisposing to thrombosis. J Nutr 126 (4 Suppl): 1285S\u20131289S","journal-title":"J Nutr"},{"key":"1591_CR18","unstructured":"Has C (2008) Epidermolysis bullosa. In: Derma-Net\u2013Online Kap 7.1. S\u00a01\u201312"},{"key":"1591_CR19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/15513819209023288","volume":"12","author":"Hawkins","year":"1992","unstructured":"Hawkins HK, Heffelfinger SC, Anderson DC (1992) Leukocyte adhesion deficiency: clinical and postmortem observations. Pediatr Pathol 12: 119\u2013130","journal-title":"Pediatr Pathol"},{"key":"1591_CR20","doi-asserted-by":"crossref","unstructured":"Helmus Y, Denecke J, Yakubenia S et al. (2006) Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter. Blood 15, 107(10): 3959\u20133966","DOI":"10.1182\/blood-2005-08-3334"},{"key":"1591_CR21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrc1012","volume":"3","author":"Hickson","year":"2003","unstructured":"Hickson ID (2003) RecQ helicases: caretakers of the genome. Nat Rev Cancer 3: 169\u2013178","journal-title":"Nat Rev Cancer"},{"key":"1591_CR22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1365-2133.1989.tb07799.x","volume":"120","author":"Higgins","year":"1989","unstructured":"Higgins EJ, Tidman MJ, Savidge GF et al. (1989) Platelet hyperaggregability in two patients with Klinefelter\u2019s syndrome complicated by leg ulcers. Br J Dermatol 120: 322","journal-title":"Br J Dermatol"},{"key":"1591_CR23","first-page":"346","volume":"104","author":"Hirschfeld","year":"2007","unstructured":"Hirschfeld G, Berneburg M, von Armin C et al. (2007) Progeroid-Syndrome. Dtsch \u00c4rztebl 104: 346\u2013353","journal-title":"Dtsch \u00c4rztebl"},{"key":"1591_CR24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1046\/j.1525-1470.2003.20312.x","volume":"20","author":"Kahofer","year":"2003","unstructured":"Kahofer P, Bruckner-Tudermann L, Metze MD et al. (2003) Dystrophic epidermolysis bullosa inverse with COL7A1 mutations and absence of GDA-J\/F3 Protein. Ped Dermatol 20: 243\u2013248","journal-title":"Ped Dermatol"},{"key":"1591_CR25","first-page":"414","volume":"43","author":"Kang","year":"1988","unstructured":"Kang SS, Zhou J, Wong PW et al. (1988) Intermediate homocysteinemia: a thermolabile variant of methylentetrahydrofolate reductase. Am J Hum Genet 43(4): 414\u2013421","journal-title":"Am J Hum Genet"},{"key":"1591_CR26","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1172\/JCI905","volume":"1","author":"Karsan","year":"1998","unstructured":"Karsan A, Cornejo CJ, Winn RK et al. (1998) Leukocyte adhesion deficiency type II is a generalized defect of de novo GDP-fucose biosynthesis. Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium. J Clin Invest 1(101): 2438\u20132445","journal-title":"J Clin Invest"},{"key":"1591_CR27","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jcem-2-11-615","volume":"2","author":"Klinefelter","year":"1942","unstructured":"Klinefelter HF, Reifenstein EC, Albright F (1942) Syndrome characterized by gynecomastia, spermatogenesis without aleydigism and increased excretion of follicle-stimulating hormone. J Clin Endocr 2: 615\u2013627","journal-title":"J Clin Endocr"},{"key":"1591_CR28","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1006\/bcmd.2000.0328","volume":"26","author":"Loukopoulos","year":"2000","unstructured":"Loukopoulos D, Voskaridou E, Kalotychou V et al. (2000) Reduction of the clinical severity of sickle cell\/beta-thalassemia with hydroxyurea: the experience of a single center in Greece. Blood Cells Mol Dis 26(5): 453\u2013466","journal-title":"Blood Cells Mol Dis"},{"key":"1591_CR29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1182\/blood.V97.1.330","volume":"97","author":"L\u00fchn","year":"2001","unstructured":"L\u00fchn K, Marquardt T, Harms E, Vestweber D (2001) Discontinuation of fucose therapy in LADII causes rapid loss of selectin ligands and rise of leukocyte counts. Blood 97: 330\u2013332","journal-title":"Blood"},{"key":"1591_CR30","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1136\/jmg.2005.038224","volume":"43","author":"Malfait","year":"2005","unstructured":"Malfait F, De Paepe A (2005) Molecular genetics in classic Ehlers-Danlos syndrome. Am J Med C Semin Med Genet 43: e36, PMIDs 16816023","journal-title":"Am J Med C Semin Med Genet"},{"key":"1591_CR31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4065\/71.9.897","volume":"71","author":"Nichols","year":"1996","unstructured":"Nichols WL, Heitt JA (1996) Activated protein C resistance and thrombosis. Mayo Clin Proc 71: 897\u2013898","journal-title":"Mayo Clin Proc"},{"key":"1591_CR32","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2133.1996.tb16262.x","volume":"134","author":"Pernod","year":"1996","unstructured":"Pernod G, Villemur B, Bosson JL et al. (1996) Leg ulcers and Klinefelter\u2019s syndrome: role of PAI\u20131. Br J Dermatol 134: 593\u2013606","journal-title":"Br J Dermatol"},{"key":"1591_CR33","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1038\/sj.emboj.7600809","volume":"5","author":"Peters","year":"2005","unstructured":"Peters T, Sindrilaru A, Hinz B et al. (2005) Wound-healing defect of CD18\u2212\/\u2212 mice due to a decrease in TGF-\u03b21 and myofibroblast differentiation. EMBO J 5(24): 3400\u20133410","journal-title":"EMBO J"},{"key":"1591_CR34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1399-0004.2004.00315.x","volume":"66","author":"Pollex","year":"2004","unstructured":"Pollex RL, Hegele RA (2004) Hutchinson Gilford progeria syndrome. Clin Genet 66: 375\u2013381","journal-title":"Clin Genet"},{"key":"1591_CR35","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","volume":"88","author":"Poort","year":"1996","unstructured":"Poort SR, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variant in the 3-untranslated region of the prothrombin gene is asociated with elevated plasma prothrombin levels and increase in thrombosis. Blood 88: 3698\u20133703","journal-title":"Blood"},{"key":"1591_CR36","doi-asserted-by":"crossref","unstructured":"Rampf J, Sunderk\u00f6tter C, Hirschfeld G et al. (2006) Methylentetrahydrofolate reductase polymorphism associated with moderate hyperhomocysteinaemia in a patient with livedo vasculopathy: treatment with vitamin supplementation and low molecular weight heparin, Br J Dermatol 155: 850\u2013852","DOI":"10.1111\/j.1365-2133.2006.07448.x"},{"key":"1591_CR37","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1006\/bcmd.2001.0473","volume":"27","author":"Roos","year":"2001","unstructured":"Roos D, Law SK (2001) Hematologically important mutations: leukocyte adhesion deficiency. Blood Cells Mol Dis 27: 1000\u20131004","journal-title":"Blood Cells Mol Dis"},{"key":"1591_CR38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1024\/0301-1526.31.3.191","volume":"31","author":"Sawhney","year":"2002","unstructured":"Sawhney H, Weedon J, Gillette P et al. (2002) Predilection of haemolytic anemia-associated leg ulcers for the medial malleolus. Vasa 31: 191\u2013193","journal-title":"Vasa"},{"key":"1591_CR39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1084\/jem.188.1.119","volume":"188","author":"Scharffetter-Kochanek","year":"1998","unstructured":"Scharffetter-Kochanek K, Lu H, Norman K et al. (1998) Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med 188(1): 119\u2013131","journal-title":"J Exp Med"},{"key":"1591_CR40","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1182\/blood.V64.6.1297.1297","volume":"64","author":"Schwarzt","year":"1984","unstructured":"Schwarzt HP, Fischer M, Hopmeier P et al. (1984) Plasma protein S deficiency in familial thrombotic disease. Blood 64: 1297\u20131300","journal-title":"Blood"},{"key":"1591_CR41","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0021-9258(18)48342-1","volume":"267","author":"Sligh","year":"1992","unstructured":"Sligh JE jr, Hurwitz MY, Zhu CM et al. (1992) An initiation codon mutation in CD18 in association with the moderate phenotype of leukocyte adhesion deficiency. J Biol Chem 267: 714\u2013718","journal-title":"J Biol Chem"},{"key":"1591_CR42","first-page":"190","volume":"10","author":"Stanger","year":"2003","unstructured":"Stanger O, Hermann W, Pietrzik K et al. (2003) Konsensuspapier der DACH-Liga Homocystein \u00fcber den rationellen klinischen Umgang mit Homocystein bei kardiovaskul\u00e4ren und thrombotischen Erkrankungen \u2013 Richtlinien und Empfehlungen. J Kardiol 10(5): 190\u2013199","journal-title":"J Kardiol"},{"key":"1591_CR43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00281-008-0121-8","volume":"30","author":"Stasia","year":"2008","unstructured":"Stasia MJ, Li XJ (2008) Genetics and immunopathology of chronic granulomatous disease. Semin Immunopathol 30: 209\u2013235","journal-title":"Semin Immunopathol"},{"key":"1591_CR44","doi-asserted-by":"crossref","unstructured":"Steinberg MH (1999) Management of sickle cell disease. N Engl J Med. 340(13): 1021\u20131030","DOI":"10.1056\/NEJM199904013401307"},{"key":"1591_CR45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1524-4725.1982.tb00283.x","volume":"8","author":"Sternberg","year":"1982","unstructured":"Sternberg N, Golan J, Sternberg I, Ben-Hur N (1982) Werner\u2019s syndrome as a cause of chronic leg ulcers. J Dermatol Surg Oncol 8: 293\u2013295","journal-title":"J Dermatol Surg Oncol"},{"key":"1591_CR46","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1001\/archderm.1977.01640110078012","volume":"113","author":"Stevens","year":"1977","unstructured":"Stevens DM, Shupack JL, Javid J, Silber R (1977) Ulcers of the leg in thalassaemia. Arch Dermatol 113: 1558\u20131560","journal-title":"Arch Dermatol"},{"key":"1591_CR47","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1002\/art.23675","volume":"58","author":"Villa-Forte","year":"2008","unstructured":"Villa-Forte A, De la Salle H, Fricker D et al. (2008) HLA Class I Deficiency syndrome mimicking Wegener\u2019s Granulomatosis. Arthritis Rheumatism 58: 2579\u20132582","journal-title":"Arthritis Rheumatism"},{"key":"1591_CR48","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1111\/j.1742-4658.2006.05438.x","volume":"273","author":"Yakubenia","year":"2006","unstructured":"Yakubenia S, Wild MK (2006) Leukocyte adhesion deficiency II. Advances and open questions. FEBS J 273: 4390\u20134398","journal-title":"FEBS J"},{"key":"1591_CR49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/qjmed\/hci112","volume":"98","author":"Zimmer","year":"2005","unstructured":"Zimmer J, Andres E, Donato L et al. (2005) Clinical and immunological aspects of HLA class I deficiency. Q J Med 98: 719\u2013727","journal-title":"Q J Med"},{"key":"1591_CR50","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1365-2133.1997.tb14940.x","volume":"136","author":"Zollner","year":"1997","unstructured":"Zollner TM, Verhaart JC, Wolter M et al (1997) Leg ulcers in Klinefelter\u2019s syndrome: further evidence for an involvement of plasminogen activator inhibitor-1. Br J Dermatol 136: 341\u2013344","journal-title":"Br J Dermatol"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-008-1591-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00105-008-1591-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-008-1591-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T05:08:17Z","timestamp":1632028097000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00105-008-1591-2"}},"subtitle":["Seltene Differenzialdiagnosen der nicht heilenden Wunde","Rare differential diagnosis of the non-healing wound"],"short-title":[],"issued":{"date-parts":[[2008,10,22]]},"references-count":50,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["1591"],"URL":"https:\/\/doi.org\/10.1007\/s00105-008-1591-2","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"value":"0017-8470","type":"print"},{"value":"1432-1173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,22]]}}}