{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:57:09Z","timestamp":1759341429148},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T00:00:00Z","timestamp":1253232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1007\/s00105-009-1794-1","type":"journal-article","created":{"date-parts":[[2009,9,18]],"date-time":"2009-09-18T03:08:39Z","timestamp":1253243319000},"page":"598-602","source":"Crossref","is-referenced-by-count":3,"title":["Ulzerationen unter Therapie mit Hydroxyharnstoff"],"prefix":"10.1007","volume":"61","author":[{"given":"S.","family":"Boneberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.A.","family":"Rupec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ruzicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,9,18]]},"reference":[{"key":"1794_CR1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000204799","volume":"86","author":"Al-Momen","year":"1991","unstructured":"Al-Momen AK (1991) Recombinant human erythropoietin induced rapid healing of a chronic leg ulcer in a patient with sickle cell disease. Acta Haematol 86:46\u201348","journal-title":"Acta Haematol"},{"key":"1794_CR2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1046\/j.1365-2133.2003.05209_7.x","volume":"148","author":"Aragane","year":"2003","unstructured":"Aragane Y, Okamoto T, Yajima A et al (2003) Hydroxyurea-induced foot ulcer successfully treated with a topical basic fibroblast growth factor product. Br J Dermatol 148:599\u2013600","journal-title":"Br J Dermatol"},{"key":"1794_CR3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7326\/0003-4819-128-1-199801010-00005","volume":"128","author":"Best","year":"1998","unstructured":"Best PJ, Daoud MS, Pittelkow MR et al (1998) Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med 128:29\u201332","journal-title":"Ann Intern Med"},{"key":"1794_CR4","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1001\/archderm.132.11.1395","volume":"132","author":"Callot-Mellot","year":"1996","unstructured":"Callot-Mellot C, Bodemer C, Chosidow O et al (1996) Cutaneous carcinoma during long-term hydroxyurea therapy: a report of 5 cases. Arch Dermatol 132:1395\u20131397","journal-title":"Arch Dermatol"},{"key":"1794_CR5","first-page":"467","volume":"137","author":"Chaine","year":"2001","unstructured":"Chaine B, Neonato MG, Girot R et al (2001) Cutaneous adverse reactions to hydroxyurea in patients with sickle cell disease. Arch Dermatol 137:467\u2013470","journal-title":"Arch Dermatol"},{"key":"1794_CR6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1365-2133.1998.02107.x","volume":"138","author":"Cribier","year":"1998","unstructured":"Cribier B, Marquart-Elbaz C, Lipsker D et al (1998) Chronic buccal ulceration induced by nicorandil. Br J Dermatol 138:372\u2013373","journal-title":"Br J Dermatol"},{"key":"1794_CR7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-2230.2004.01586.x","volume":"29","author":"De","year":"2004","unstructured":"De Benedittis M, Petruzzi M, Giardina C et al (2004) Oral squamous cell carcinoma during long-term treatment with hydroxyurea. Clin Exp Dermatol 29:605\u2013607","journal-title":"Clin Exp Dermatol"},{"key":"1794_CR8","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1046\/j.1365-4362.2002.01623.x","volume":"41","author":"Demircay","year":"2002","unstructured":"Demircay Z, Comert A, Adiguzel C (2002) Leg ulcers and hydroxyurea: report of three cases with essential thrombocythemia. Int J Dermatol 41:872\u2013874","journal-title":"Int J Dermatol"},{"key":"1794_CR9","doi-asserted-by":"crossref","unstructured":"Dressler WFC, Stein R (1869) \u00dcber den Hydroxylharnstoff. Lustus Liebig\u2019s Ann Chem Pharm 150:242\u2013252","DOI":"10.1002\/jlac.18691500212"},{"key":"1794_CR10","first-page":"919","volume":"128","author":"Est\u00e8ve","year":"2001","unstructured":"Est\u00e8ve E, Georgescu V, Heitzmann P et al (2001) Carcinomes cutan\u00e9s et buccaux multiples apr\u00e8s traitement par l\u2019hydroxyuree. Ann Dermatol Venereol 128:919\u2013921","journal-title":"Ann Dermatol Venereol"},{"key":"1794_CR11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.7326\/0003-4819-132-5-200003070-00017","volume":"132","author":"Flores","year":"2000","unstructured":"Flores F, Eaglstein WA, Kirsner RS (2000) Hydroxyurea-induced leg ulcers treated with Apligraf. Ann Intern Med 132:417\u2013418","journal-title":"Ann Intern Med"},{"key":"1794_CR12","first-page":"343","volume":"14","author":"Friedrich","year":"2004","unstructured":"Friedrich S, Raff K, Landthaler M et al (2004) Cutaneous ulcerations on hands and heels secondary to long-term hydroxyurea treatment. Eur J Dermatol 14:343\u2013346","journal-title":"Eur J Dermatol"},{"key":"1794_CR13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0140-6736(90)90101-A","volume":"335","author":"Gilquin","year":"1990","unstructured":"Gilquin J, Weiss L, Kazatchkine MD (1990) Genital and oral erosions induced by foscarnet. Lancet 335:287","journal-title":"Lancet"},{"key":"1794_CR14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.14219\/jada.archive.1975.0119","volume":"90","author":"Guggenheimer","year":"1975","unstructured":"Guggenheimer J, Ismail YH (1975) Oral ulcerations associated with indomethacin therapy: report of three cases. J Am Dent Assoc 90:632\u2013634","journal-title":"J Am Dent Assoc"},{"key":"1794_CR15","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0755-4982(06)74775-3","volume":"35","author":"Hanchi","year":"2006","unstructured":"Hanchi I, Zeglaoui F, Ezzine N et al (2006) Ulc\u00e8re de jambe chez une malade trait\u00e9e par hydroxyur\u00e9e pour maladie de Vaquez. Presse Med 35:1174\u20131176","journal-title":"Presse Med"},{"key":"1794_CR16","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1080\/1042819031000067864","volume":"44","author":"Karincaoglu","year":"2003","unstructured":"Karincaoglu Y, Kaya E, Esrefoglu M et al (2003) Development of large genital ulcer due to hydroxyurea treatment in a patient with chronic myeloid leukemia and Behcet\u2019s disease. Leuk Lymphoma 44:1063\u20131065","journal-title":"Leuk Lymphoma"},{"key":"1794_CR17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1001\/archderm.1975.01630140041002","volume":"111","author":"Kennedy","year":"1975","unstructured":"Kennedy BJ, Smith LR, Goltz RW (1975) Skin changes secondary to hydroxyurea therapy. Arch Dermatol 111:183\u2013187","journal-title":"Arch Dermatol"},{"key":"1794_CR18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/030089168607200314","volume":"72","author":"Montefusco","year":"1986","unstructured":"Montefusco E, Alimena G, Gastaldi R et al (1986) Unusual dermatologic toxicity of long-term therapy with hydroxyurea in chronic myelogenous leukemia. Tumori 72:317\u2013321","journal-title":"Tumori"},{"key":"1794_CR19","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1182\/blood.V90.9.3370","volume":"90","author":"Najean","year":"1997","unstructured":"Najean Y, Rain JD (1997) Treatment of polycythemia vera: the use of hydroxyurea and pipobroman in 292 patients under the age of 65 years. Blood 90:3370\u20133377","journal-title":"Blood"},{"key":"1794_CR20","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1258\/0022215001904518","volume":"114","author":"Paleri","year":"2000","unstructured":"Paleri V, Lindsey L (2000) Oral ulcers caused by hydroxyurea. J Laryngol Otol 114:976\u2013977","journal-title":"J Laryngol Otol"},{"key":"1794_CR21","first-page":"1310","volume":"143","author":"Romanelli","year":"2007","unstructured":"Romanelli M, Dini V, Romanelli P (2007) Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix. Arch Dermatol 143:1310\u20131313","journal-title":"Arch Dermatol"},{"key":"1794_CR22","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/BF01716922","volume":"7","author":"Rosenthal","year":"1928","unstructured":"Rosenthal F, Wislicki L, Kollek L (1928) \u00dcber die Beziehungen von schweren Blutvergiftungen zu Abbauprodukten des Eiweisses: Ein Beitrag zum Entstehungsmechanismus der pernizi\u00f6sen An\u00e4mie. Wien Klin Wochenschr 7:972\u2013977","journal-title":"Wien Klin Wochenschr"},{"key":"1794_CR23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1365-2133.1995.tb02677.x","volume":"133","author":"Senet","year":"1995","unstructured":"Senet P, Aractingi S, Porneuf M et al (1995) Hydroxyurea-induced dermatomyositis-like eruption. Br J Dermatol 133:455\u2013459","journal-title":"Br J Dermatol"},{"key":"1794_CR24","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1001\/archderm.135.7.818","volume":"135","author":"Sirieix","year":"1999","unstructured":"Sirieix ME, Debure C, Baudot N et al (1999) Leg ulcers and hydroxyurea: forty-one cases. Arch Dermatol 135:818\u2013820","journal-title":"Arch Dermatol"},{"key":"1794_CR25","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1182\/blood.V94.4.1479","volume":"94","author":"Stagno","year":"1999","unstructured":"Stagno F, Guglielmo P, Consoli U et al (1999) Successful healing of hydroxyurea-related leg ulcers with topical granulocyte-macrophage colony-stimulating factor. Blood 94:1479\u20131480","journal-title":"Blood"},{"key":"1794_CR26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/0002-9343(85)90297-9","volume":"78","author":"Stahl","year":"1985","unstructured":"Stahl Rl, Silber R (1985) Vasculitic leg ulcers in chronic myelogenous leukemia. Am J Med 78:869\u2013872","journal-title":"Am J Med"},{"key":"1794_CR27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/jm00338a026","volume":"6","author":"Stearns","year":"1963","unstructured":"Stearns B, Losee KA, Bernstein J (1963) Hydroxyurea. A new type of potential antitumor agent. J Med Chem 6:201","journal-title":"J Med Chem"},{"key":"1794_CR28","first-page":"413","volume":"81","author":"Warner","year":"2008","unstructured":"Warner J, Brown A, Whitmore Se et al (2008) Mucocutaneous ulcerations secondary to methotrexate. Cutis 81:413\u2013416","journal-title":"Cutis"},{"key":"1794_CR29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0190-9622(98)70394-9","volume":"39","author":"Weinlich","year":"1998","unstructured":"Weinlich G, Schuler G, Greil R et al (1998) Leg ulcers associated with long-term hydroxyurea therapy. J Am Acad Dermatol 39:372\u2013374","journal-title":"J Am Acad Dermatol"},{"key":"1794_CR30","first-page":"ECR36","volume":"88","author":"Yokota","year":"2003","unstructured":"Yokota K, Tasaka T, Iwata K et al (2003) Huge post-operative ulcer following hydroxyurea therapy in a patient with polycythemia vera. Haematologica 88:ECR36","journal-title":"Haematologica"},{"key":"1794_CR31","first-page":"526","volume":"27","author":"Young","year":"1967","unstructured":"Young CW, Schochetman G, Karnofsky DA (1967) Hydroxyurea-induced inhibition of deoxyribonucleotide synthesis: studies in intact cells. Cancer Res 27:526\u2013534","journal-title":"Cancer Res"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-009-1794-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00105-009-1794-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-009-1794-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:05:41Z","timestamp":1590138341000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00105-009-1794-1"}},"subtitle":["Drei Fallberichte mit Literatur\u00fcberblick"],"short-title":[],"issued":{"date-parts":[[2009,9,18]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["1794"],"URL":"https:\/\/doi.org\/10.1007\/s00105-009-1794-1","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"value":"0017-8470","type":"print"},{"value":"1432-1173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,18]]}}}