{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:27:12Z","timestamp":1791934032153,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T00:00:00Z","timestamp":1303257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1007\/s00105-010-2113-6","type":"journal-article","created":{"date-parts":[[2011,4,18]],"date-time":"2011-04-18T15:47:27Z","timestamp":1303141647000},"page":"516-523","source":"Crossref","is-referenced-by-count":18,"title":["Medikamente","Medications"],"prefix":"10.1007","volume":"62","author":[{"given":"J.","family":"Dissemond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,4,20]]},"reference":[{"key":"2113_CR1","first-page":"59","volume":"12","author":"Anonymous","year":"2003","unstructured":"Anonymous (2003) Cutaneous ulceration with methotrexate. Prescire Int 12:59\u201360","journal-title":"Prescire Int"},{"key":"2113_CR2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7326\/0003-4819-128-1-199801010-00005","volume":"128","author":"Best","year":"1998","unstructured":"Best PJ, Daoud MS, Pittelkow MR, Petitt RM (1998) Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med 128:29\u201332","journal-title":"Ann Intern Med"},{"key":"2113_CR3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2230.2007.02650.x","volume":"33","author":"Birnie","year":"2008","unstructured":"Birnie A, Dearing N, Littlewood S, Carlin E (2008) Nicorandil-induced ulceration of the penis. Clin Exp Dermatol 33:215\u2013216","journal-title":"Clin Exp Dermatol"},{"key":"2113_CR4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/bmj.297.6647.562-f","volume":"297","author":"Carmichael","year":"1988","unstructured":"Carmichael AJ, Paul CJ (1988) Vasculitic leg ulcers associated with diltiazem. BMJ 297(6647):562","journal-title":"BMJ"},{"key":"2113_CR5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1365-2168.2000.01352.x","volume":"87","author":"Chan","year":"2000","unstructured":"Chan Y, Valenti D, Mansfield AO, Stansby G (2000) Warfarin induced skin necrosis. Br J Surg 87:266\u2013272","journal-title":"Br J Surg"},{"key":"2113_CR6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2133.2005.07025.x","volume":"154","author":"Cooke","year":"2006","unstructured":"Cooke NS, Tolland JP, Dolan OM (2006) Nicorandil-associated perianal ulceration: a case series of 10 patients. Br J Dermatol 154:199\u2013200","journal-title":"Br J Dermatol"},{"key":"2113_CR7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/0378-6323.31898","volume":"73","author":"De","year":"2007","unstructured":"De D, Dogra S, Kanwar AJ (2007) Pentazocine-induced leg ulcers and fibrous papules. Indian J Dermatol Venereol Leprol 73:112\u2013113","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2113_CR8","first-page":"450","volume":"11","author":"Del","year":"2001","unstructured":"Del Pozo J, Mart\u00ednez W, Garc\u00eda-Silva J et al (2001) Cutaneous ulceration as a sign of methotrexate toxicity. Eur J Dermatol 11:450\u2013452","journal-title":"Eur J Dermatol"},{"key":"2113_CR9","unstructured":"Dissemond J (2009) Ulcus cruris \u2013 Grundlagen, Diagnostik und Therapie, 3. Aufl. UNI-MED, Bremen London Boston"},{"key":"2113_CR10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-4632.2004.02450.x","volume":"45","author":"Dissemond","year":"2006","unstructured":"Dissemond J, H\u00f6ft D, Knab J et al (2006) Leg ulcer in a patient associated with hydroxyurea therapy. Int J Dermatol 45:158\u2013160","journal-title":"Int J Dermatol"},{"key":"2113_CR11","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1503\/cmaj.081042","volume":"180","author":"Dissemond","year":"2009","unstructured":"Dissemond J, K\u00f6rber A (2009) Hydroxyurea-induced ulcers on the leg. Can Med Assoc J 180:1132","journal-title":"Can Med Assoc J"},{"key":"2113_CR12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/bmj.1.6061.616","volume":"1","author":"El-Ghobarey","year":"1977","unstructured":"El-Ghobarey M, Maurikasis M, Morgan R, Mathieu J (1977) Delayed healing of varicose ulcer with levamisole. Br Med J 1:616\u2013617","journal-title":"Br Med J"},{"key":"2113_CR13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1055\/s-2008-1063751","volume":"116","author":"Ellbr\u00fcck","year":"1991","unstructured":"Ellbr\u00fcck D, Wankm\u00fcller H, Rasche H, Seifried E (1991) The clinical course of coumarin-induced necrosis. Dtsch Med Wochenschr 116:1307\u20131312","journal-title":"Dtsch Med Wochenschr"},{"key":"2113_CR14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1067\/mjd.2001.114564","volume":"45","author":"Eming","year":"2001","unstructured":"Eming SA, Peters T, Hartmann K et al (2001) Lichenoid chronic graft-versus-host-disease-like acrodermatitis induced by hydroxyurea. J Am Acad Dermatol 45:321\u2013323","journal-title":"J Am Acad Dermatol"},{"key":"2113_CR15","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/archderm.120.7.927","volume":"120","author":"Franson","year":"1984","unstructured":"Franson TR, Rose HD, Spivey MR et al (1984) Late-onset, warfarin-caused necrosis occurring in a patient with infectious mononucleosis. Arch Dermatol 120:927\u2013931","journal-title":"Arch Dermatol"},{"key":"2113_CR16","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/art.21449","volume":"53","author":"Gibson","year":"2005","unstructured":"Gibson A, Gardner J, O\u2019Donnell J (2005) Erythropoietin and painful leg ulcers: thrombosis or vasculitis? Arthritis Rheum 53:792","journal-title":"Arthritis Rheum"},{"key":"2113_CR17","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00006534-198510000-00029","volume":"76","author":"Gottlieb","year":"1985","unstructured":"Gottlieb JR, Lewis VL Jr, Bashioum RW (1985) Care of pentamadine ulcers in AIDS patients. Plast Reconstr Surg 76:630\u2013632","journal-title":"Plast Reconstr Surg"},{"key":"2113_CR18","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s00105-007-1300-6","volume":"58","author":"Helbig","year":"2007","unstructured":"Helbig D, Hillen U, Grabbe S, Dissemond J (2007) Haut- und Schleimhautulzerationen bei Heparin-induzierter Thrombozytopenie (HIT) II. Hautarzt 58:774\u2013780","journal-title":"Hautarzt"},{"key":"2113_CR19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000051761","volume":"203","author":"Holm","year":"2001","unstructured":"Holm EA, Balslev E, Jemec GBE (2001) Vasculitis occurring during leflunomide therapy. Dermatology 203:258\u2013259","journal-title":"Dermatology"},{"key":"2113_CR20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000077844","volume":"208","author":"Hong","year":"2004","unstructured":"Hong SB, Lee MH (2004) A case of propylthiouracil-induced pyoderma gangrenosum associated with antineutrophil cytoplasmic antibody. Dermatology 208:339\u2013341","journal-title":"Dermatology"},{"key":"2113_CR21","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/art.1780220819","volume":"22","author":"Houston","year":"1979","unstructured":"Houston BD, Crouch ME, Brick JE, DiBartolomeo AG (1979) Apparent vasculitis associated with propylthiouracil use. Arthritis Rheum 22:925\u2013928","journal-title":"Arthritis Rheum"},{"key":"2113_CR22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1610-0387.2006.05934.x","volume":"4","author":"Jakob","year":"2006","unstructured":"Jakob A, Porstmann R, Rompel R (2006) Skin ulceration after leflunomide treatment in two patients with rheumatoid arthritis. J Dtsch Dermatol Ges 4:324\u2013327","journal-title":"J Dtsch Dermatol Ges"},{"key":"2113_CR23","unstructured":"Kikuchi K, Arita K, Tateishi Y et al (im Druck) Recurrence of hydroxyurea-induced leg ulcer after discontinuation of treatment. Acta Derm Venereol"},{"key":"2113_CR24","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/bmj.2.6201.1330","volume":"2","author":"Kissin","year":"1979","unstructured":"Kissin MW, Williamson RC (1979) Hydrallazine-induced SLE-like syndrome presenting as a leg ulcer. Br Med J 2:1330","journal-title":"Br Med J"},{"key":"2113_CR25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000188692","volume":"71","author":"Kitano","year":"1995","unstructured":"Kitano Y, Nomura S, Saiki T, Osawa G (1995) Leg ulceration during amezinium methylsulfate therapy for hypotension in a hemodialyzed patient with generalized vascular calcification. Nephron 71:115","journal-title":"Nephron"},{"key":"2113_CR26","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1468-3083.2005.01118.x","volume":"19","author":"Knab","year":"2005","unstructured":"Knab J, Goos M, Dissemond J (2005) Successful treatment of a leg ulcer occurring in a rheumatoid arthritis patient under leflunomide therapy. J Eur Acad Dermatol Venereol 19:243\u2013246","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2113_CR27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000188232","volume":"68","author":"Leblanc","year":"1994","unstructured":"Leblanc M, Roy LF, Legault L et al (1994) Severe skin necrosis associated with heparin in hemodialysis. Nephron 68:133\u2013137","journal-title":"Nephron"},{"key":"2113_CR28","first-page":"219","volume":"47","author":"Luca","year":"1999","unstructured":"Luca S, Romeo S (1999) Edema and skin ulcers of the lower limbs as a collateral effect of nifedipine. A clinical case report. Minerva Cardioangiol 47:219\u2013222","journal-title":"Minerva Cardioangiol"},{"key":"2113_CR29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1345\/aph.1A347","volume":"336","author":"McCoy","year":"2002","unstructured":"McCoy CM (2002) Leflunomide-associated skin ulceration. Ann Pharmacother 336:1009\u20131011","journal-title":"Ann Pharmacother"},{"key":"2113_CR30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2133.2006.07643.x","volume":"156","author":"McKenna","year":"2007","unstructured":"McKenna DJ, Donnelly J, Armstrong DK (2007) Nicorandil-induced leg ulceration. Br J Dermatol 156:394\u2013396","journal-title":"Br J Dermatol"},{"key":"2113_CR31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1365-2133.2004.06121.x","volume":"151","author":"Muniesa","year":"2004","unstructured":"Muniesa C, Marcoval J, Moreno A et al (2004) Coumarin necrosis induced by renal insufficiency. Br J Dermatol 151:502\u2013504","journal-title":"Br J Dermatol"},{"key":"2113_CR32","first-page":"169","volume":"44","author":"Oberste-Lehn","year":"1969","unstructured":"Oberste-Lehn H, Kaulen-Becker L (1969) Necroses after barbituric acid and noludar poisoning. Z Haut Geschlechtskr 44(5):169\u2013174","journal-title":"Z Haut Geschlechtskr"},{"key":"2113_CR33","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0190-9622(96)90097-3","volume":"35","author":"Pearce","year":"1996","unstructured":"Pearce HP, Wilson BB (1996) Erosion of psoriatic plaques: an early sign of methotrexate toxicity. J Am Acad Dermatol 35:835\u2013838","journal-title":"J Am Acad Dermatol"},{"key":"2113_CR34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1046\/j.0307-6938.2001.00944.x","volume":"27","author":"Powell","year":"2002","unstructured":"Powell J, Grech H, Holder J (2002) A boy with cutaneous necrosis occurring during treatment with levamisole. Clin Exp Dermatol 27:32\u201333","journal-title":"Clin Exp Dermatol"},{"key":"2113_CR35","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1365-4632.2004.02291.x","volume":"44","author":"Prasad","year":"2005","unstructured":"Prasad HR, Khaitan BK, Ramam M et al (2005) Diagnostic clinical features of pentazocine-induced ulcers. Int J Dermatol 44:910\u2013915","journal-title":"Int J Dermatol"},{"key":"2113_CR36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-2007-959325","volume":"132","author":"Rappoport","year":"2007","unstructured":"Rappoport L, K\u00f6rber A, Grabbe S, Dissemond J (2007) Auftreten von Ulcera crurum durch Anagrelid. Dtsch Med Wochenschr 132:319\u2013321","journal-title":"Dtsch Med Wochenschr"},{"key":"2113_CR37","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1046\/j.1365-2133.1999.02833.x","volume":"140","author":"Rongioletti","year":"1999","unstructured":"Rongioletti F, Ghio L, Ginevri F et al (1999) Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long-term treatment with levamisole in children. Br J Dermatol 140:948\u2013951","journal-title":"Br J Dermatol"},{"key":"2113_CR38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2165\/00003088-200241060-00003","volume":"41","author":"Rozman","year":"2002","unstructured":"Rozman B (2002) Clinical pharmacokinetics of leflunomide. Clin Pharmacokinet 41:421\u2013430","journal-title":"Clin Pharmacokinet"},{"key":"2113_CR39","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1532-5415.1995.tb07038.x","volume":"43","author":"Siddiqui","year":"1995","unstructured":"Siddiqui MA, Zaman MN (1995) Recurrent and chronic leg ulcers secondary to furosemide-induced bullos pemphigoid. J Am Geriatr Soc 43:1183\u20131184","journal-title":"J Am Geriatr Soc"},{"key":"2113_CR40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-4362.1997.tb03058.x","volume":"36","author":"Siregusa","year":"1997","unstructured":"Siregusa M, Alberti A, Schepis C (1997) Skin ulcers in a young woman on low-dose estrogen-combination pill. Int J Dermatol 36:317\u2013318","journal-title":"Int J Dermatol"},{"key":"2113_CR41","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1001\/archderm.135.7.818","volume":"135","author":"Sirieix","year":"1999","unstructured":"Sirieix ME, Debure C, Baudot N et al (1999) Leg ulcers and hydroxyurea: forty-one cases. Arch Dermatol 135:818\u2013820","journal-title":"Arch Dermatol"},{"key":"2113_CR42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2340\/0001555574140142","volume":"74","author":"Tamir","year":"1994","unstructured":"Tamir A, Wolf R, Brenner S (1994) Leukocytoclastic vasculitis: another coumarin-induced hemorrhagic reaction. Acta Derm Venereol 74:138\u2013139","journal-title":"Acta Derm Venereol"},{"key":"2113_CR43","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/thy.2008.0192","volume":"19","author":"Tsuboi","year":"2009","unstructured":"Tsuboi K, Ishihara Y, Ishikawa M et al (2009) Unusual oral ulceration, skin rash, and fever in a patient receiving propylthiouracil. Thyroid 19:421\u2013422","journal-title":"Thyroid"},{"key":"2113_CR44","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0190-9622(98)70394-9","volume":"8","author":"Weinlich","year":"1998","unstructured":"Weinlich G, Schuler G, Greil R et al (1998) Leg ulcers associated with long-term hydroxyurea therapie. J Am Acad Dermatol 8:372\u2013374","journal-title":"J Am Acad Dermatol"},{"key":"2113_CR45","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1464-410X.2010.09463.x","volume":"107","author":"Yap","year":"2011","unstructured":"Yap T, Philippou P, Perry M et al (2011) Nicorandil-induced penile ulcerations: a case series. BJU Int 107:268\u2013271","journal-title":"BJU Int"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-010-2113-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00105-010-2113-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-010-2113-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T06:25:11Z","timestamp":1712384711000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00105-010-2113-6"}},"subtitle":["Eine seltene Ursache f\u00fcr ein Ulcus cruris","A rare cause for leg ulcers"],"short-title":[],"issued":{"date-parts":[[2011,4,20]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["2113"],"URL":"https:\/\/doi.org\/10.1007\/s00105-010-2113-6","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"value":"0017-8470","type":"print"},{"value":"1432-1173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,20]]}}}