{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T14:08:41Z","timestamp":1745849321196},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00105-018-4153-2","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T12:39:15Z","timestamp":1521722355000},"page":"278-289","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Schwere Hautreaktionen auf neue Medikamente"],"prefix":"10.1007","volume":"69","author":[{"given":"M.","family":"Mockenhaupt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Paulmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"4153_CR1","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1001\/archderm.138.8.1019","volume":"138","author":"A Auquier-Dunant","year":"2002","unstructured":"Auquier-Dunant A, Mockenhaupt M, Naldi L, Correia O, Schr\u00f6der W, Roujeau JC (2002) Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Arch Dermatol 138:1019\u20131024","journal-title":"Arch Dermatol"},{"key":"4153_CR2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/bjd.12125","volume":"3","author":"A Barbaud","year":"2013","unstructured":"Barbaud A, Collet E, Milpied B (2013) A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions. Br J Dermatol 3:555\u2013562","journal-title":"Br. J. Dermatol."},{"key":"4153_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","volume":"129","author":"S Bastuji-Garin","year":"1993","unstructured":"Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC (1993) Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol 129:92\u201396","journal-title":"Arch Dermatol"},{"key":"4153_CR4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/S1085-5629(96)80038-1","volume":"15","author":"H Bocquet","year":"1996","unstructured":"Bocquet H, Bagot M, Roujeau JC (1996) Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). Semin Cutan Med Surg 15:250\u2013257","journal-title":"Semin Cutan Med Surg"},{"issue":"5","key":"4153_CR5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1055\/s-0031-1299530","volume":"229","author":"A Chronopoulos","year":"2012","unstructured":"Chronopoulos A, Mockenhaupt M, Pleyer U (2012) Okul\u00e4re Beteiligung bei Stevens-Johnson-Syndrom und Toxisch epidermale Nekrolyse. Klin Monbl Augenheilkd 229(5):534\u2013539","journal-title":"Klin Monbl Augenheilkd"},{"key":"4153_CR6","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/428486a","volume":"428","author":"WH Chung","year":"2004","unstructured":"Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT (2004) A marker for Stevens-Johnson syndrome. Nature 428:486","journal-title":"Nature"},{"issue":"2","key":"4153_CR7","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/bjd.13505","volume":"172","author":"TA Duong","year":"2015","unstructured":"Duong TA, de Prost N, Ingen-Housz-Oro S, Carri\u00e9 AS, Zerah F, Valeyrie-Allanore L, Bagot M, Chosidow O, Roujeau JC, Wolkenstein P, Maitre B (2015) Stevens-Johnson syndrome and toxic epidermal necrolysis: follow-up of pulmonary function after remission. Br J Dermatol 172(2):400\u2013405","journal-title":"Br J Dermatol"},{"key":"4153_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00002030-200109280-00014","volume":"15","author":"JP Fagot","year":"2001","unstructured":"Fagot JP, Mockenhaupt M, Bouwes Bavinck JN, Naldi L, Viboud C, Roujeau JC (2001) Nevirapine and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis \u2013 preliminary results of a\u00a0case-control study. AIDS 15:1\u20136","journal-title":"AIDS"},{"key":"4153_CR9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1750-1172-6-52","volume":"6","author":"E Genin","year":"2011","unstructured":"Genin E, Schumacher M, Roujeau J, Naldi L, Li\u00df Y, Kazma R, Sekula P, Hovnanian A, Mockenhaupt M (2011) Genome-wide association study of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe. Orphanet J Rare Dis 6:52","journal-title":"Orphanet J Rare Dis"},{"issue":"3","key":"4153_CR10","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/tpj.2013.40","volume":"14","author":"E Genin","year":"2013","unstructured":"Genin E, Chen DP, Hung SI, Sekula P, Schumacher M, Chang PY, Tsai SH, Wu TL, Bell\u00f3n T, Tamouza R, Fortier C, Toubert A, Charron D, Hovnanian A, Wolkenstein P, Chung WH, Mockenhaupt M, Roujeau JC (2013) HLA-A*3101 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis. Pharmacogenomics 14(3):281\u2013288","journal-title":"Pharmacogenomics"},{"issue":"1","key":"4153_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jaad.2007.08.036","volume":"58","author":"S Halevy","year":"2008","unstructured":"Halevy S, Ghislain PD, Mockenhaupt M, Fagot JP, Bouwes Bavinck JN, Sidoroff A, Naldi L, Dunant A, Viboud C, Roujeau JC (2008) Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel. J\u00a0Am Acad Dermatol 58(1):25\u201332","journal-title":"J Am Acad Dermatol"},{"key":"4153_CR12","first-page":"54","volume-title":"Erythema exsudativum multiforme. Atlas der Hautkrankheiten","author":"F Hebra von","year":"1866","unstructured":"von Hebra F (1866) Erythema exsudativum multiforme. Atlas der Hautkrankheiten Bd. 6. Kaiserliche Akademie der Wissenschaften, Wien, S\u00a054\u201355"},{"issue":"11","key":"4153_CR13","doi-asserted-by":"publisher","first-page":"4134","DOI":"10.1073\/pnas.0409500102","volume":"102","author":"SI Hung","year":"2005","unstructured":"Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT (2005) HLA-B*5801 allele as a\u00a0genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S\u00a0A 102(11):4134\u20134139","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4153_CR14","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/j.1365-2133.2006.07704.x","volume":"156","author":"SH Kardaun","year":"2007","unstructured":"Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC (2007) Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a\u00a0DRESS syndrome really exist? Br J Dermatol 156:609\u2013611","journal-title":"Br J Dermatol"},{"key":"4153_CR15","first-page":"393","volume":"20","author":"Y Li\u00df","year":"2012","unstructured":"Li\u00df Y, Mockenhaupt M (2012) Schwere arzneimittelinduzierte Hautreaktionen: Akute generalisierte exanthematische Pustulose und \u201cdrug reactions with eosinophilia and systemic symptoms\u201d. Allergo\u00a0J 20:393\u2013405","journal-title":"Allergo J"},{"key":"4153_CR16","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1365-2133.1956.tb12766.x","volume":"68","author":"A Lyell","year":"1956","unstructured":"Lyell A (1956) Toxic epidermal necrolysis: an eruption resembling scalding of the skin. Br J Dermatol 68:355\u2013361","journal-title":"Br J Dermatol"},{"key":"4153_CR17","first-page":"68","volume":"1","author":"L Mardivirin","year":"2010","unstructured":"Mardivirin L, Valeyrie-Allanore L, Branlant-Redon E, Beneton N, Jidar K, Barbaud A, Crickx B, Ranger-Rogez S, Descamps V (2010) Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a\u00a0direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro. Eur J Dermatol 1:68\u201373","journal-title":"Eur J Dermatol"},{"key":"4153_CR18","unstructured":"Mockenhaupt M (2007) Schwere arzneimittelinduzierte Hautreaktionen \u2013 Klinik, Definition, diagnostische Kriterien und Ma\u00dfnahmen. CME Dermatologie"},{"key":"4153_CR19","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/978-3-540-29316-3_34","volume-title":"Braun-Falco\u2019s Dermatology","author":"M Mockenhaupt","year":"2009","unstructured":"Mockenhaupt M (2009) Severe cutaneous adverse reactions. In: Burgdorf WHC, Plewig G, Wolff HH, al (Hrsg) Braun-Falco\u2019s Dermatology. Springer, Heidelberg, S 473\u2013484"},{"issue":"3","key":"4153_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5414\/ALX01508","volume":"35","author":"M Mockenhaupt","year":"2012","unstructured":"Mockenhaupt M (2012) Epidemiologie von kutanen Arzneimittelreaktionen. Allergologie 35(3):131\u2013144","journal-title":"Allergologie"},{"key":"4153_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1055\/s-0030-1255561","volume":"36","author":"M Mockenhaupt","year":"2010","unstructured":"Mockenhaupt M, Li\u00df Y (2010) Schwere bull\u00f6se arzneimittelinduzierte Hautreaktionen. Akt Dermatol 36:1\u201312","journal-title":"Akt Dermatol"},{"key":"4153_CR22","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/j.0022-202X.2005.23642.x","volume":"124","author":"M Mockenhaupt","year":"2005","unstructured":"Mockenhaupt M, Idzko M, Grosber M, Sch\u00f6pf E, Norgauer J (2005) Epidemilogy of staphylococcal scalded skin syndrome in Germany. J\u00a0Invest Dermatol 124:700\u2013703","journal-title":"J Invest Dermatol"},{"issue":"1","key":"4153_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/sj.jid.5701033","volume":"128","author":"M Mockenhaupt","year":"2008","unstructured":"Mockenhaupt M, Viboud C, Dunant A, Naldi L, Halevy S, Bouwes-Bavinck JN, Sidoroff A, Schneck J, Roujeau JC, Flahault A (2008) Stevens-Johnson syndrome and toxic epidermal necrolysis: Assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J\u00a0Invest Dermatol 128(1):35\u201344","journal-title":"J Invest Dermatol"},{"issue":"3","key":"4153_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/CJI.0000000000000112","volume":"39","author":"N Nayar","year":"2016","unstructured":"Nayar N, Briscoe B, Penas PF (2016) Toxic epidermal necrolysis-like reaction with severe satellite cell necrosis associated with nivolumab in a\u00a0patient with ipilimumab refractory metastatic melanoma. J\u00a0Immunother 39(3):149\u2013152","journal-title":"J Immunother"},{"key":"4153_CR25","first-page":"625","volume":"13","author":"M Paulmann","year":"2015","unstructured":"Paulmann M, Mockenhaupt M (2015) Schwere arzneimittelinduzierte Hautreaktionen: Klinik, Diagnose, \u00c4tiologie und Therapie. J\u00a0Dtsch Dermatol Ges 13:625\u2013645","journal-title":"J Dtsch Dermatol Ges"},{"key":"4153_CR26","first-page":"1","volume":"22","author":"M Paulmann","year":"2016","unstructured":"Paulmann M, Mockenhaupt M (2016) Severe drug hypersensitivity reaction: clinical pattern. Diagnosis, etiology and therapeutic options. Curr Pharm Des 22:1\u201310","journal-title":"Curr Pharm Des"},{"issue":"3 Suppl","key":"4153_CR27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jaci.2010.11.046","volume":"127","author":"EJ Phillips","year":"2011","unstructured":"Phillips EJ, Chung WH, Mockenhaupt M, Roujeau JC, Mallal SA (2011) Drug hypersensitivity: pharmacogenetics and clinical syndromes. J\u00a0Allergy Clin Immunol 127(3 Suppl):60\u201366","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"4153_CR28","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/sj.tpj.6500356","volume":"6","author":"C Lonjou","year":"2006","unstructured":"Lonjou C, Thomas L, Borot N, Ledger N, de Toma C, LeLouet H, Graf E, Schumacher M, Hovnanian A, Mockenhaupt M, Roujeau JC, RegiSCAR Group (2006) A marker for Stevens-Johnson-syndrome and toxic epidermal necrolysis: ethnicity matters. Pharmacogenomics\u00a0J 6(4):265\u2013268","journal-title":"Pharmacogenomics J"},{"issue":"2","key":"4153_CR29","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/FPC.0b013e3282f3ef9c","volume":"18","author":"C Lonjou","year":"2008","unstructured":"Lonjou C, Borot N, Sekula P, Ledger N, Thomas L, Halevy S, Naldi L, Bouwes-Bavinck JN, Sidoroff A, de Toma C, Schumacher M, Roujeau JC, Hovnanian A, Mockenhaupt M, RegiSCAR study group (2008) A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 18(2):99\u2013107","journal-title":"Pharmacogenet Genomics"},{"issue":"1","key":"4153_CR30","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/clpt.2009.252","volume":"88","author":"B Sassolas","year":"2010","unstructured":"Sassolas B, Haddad C, Mockenhaupt M, Dunant A, Li\u00df Y, Bork K, Haustein UF, Vieluf D, Roujeau JC, Le Louet H, RegiSCAR study group (2010) ALDEN an algorithm for assessment of drug causality in Stevens-Johnson-syndrome and Toxic epidermal necrolysis. Comparison with case-control analysis. Clin Pharmacol Ther 88(1):60\u201368","journal-title":"Clin Pharmacol Ther"},{"key":"4153_CR31","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/bjd.12501","volume":"169","author":"SH Kardaun","year":"2013","unstructured":"Kardaun SH, Sekula P, Valeyrie-Allanore L, Li\u00df Y, Chu CY, Creamer D, Sidoroff A, Naldi L, Mockenhaupt M, Roujeau JC, RegiSCAR study group (2013) Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective regiSCAR study. Br J Dermatol 169:1071\u20131080","journal-title":"Br J Dermatol"},{"issue":"5","key":"4153_CR32","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/jid.2012.510","volume":"133","author":"P Sekula","year":"2013","unstructured":"Sekula P, Dunant A, Mockenhaupt M, Naldi L, Bouwes Bavinck JN, Halevy S, Kardaun S, Sidoroff A, Liss Y, Schumacher M, Roujeau JC, RegiSCAR study group (2013) Comprehensive survival analysis of a\u00a0cohort of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. J\u00a0Invest Dermatol 133(5):1197\u20131204","journal-title":"J Invest Dermatol"},{"key":"4153_CR33","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1056\/NEJM199512143332404","volume":"333","author":"JC Roujeau","year":"1995","unstructured":"Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F, Mockenhaupt M, Paoletti C, Shapiro S, Shear N, Sch\u00f6pf E, Kaufman DW (1995) Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N\u00a0Eng J Med 333:1600\u20131607","journal-title":"N Eng J Med"},{"key":"4153_CR34","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/0895-4356(96)00035-2","volume":"49","author":"B Rzany","year":"1996","unstructured":"Rzany B, Mockenhaupt M, Baur S, Schr\u00f6der W, Stocker U, Mueller J, Holl\u00e4nder N, Bruppacher R, Sch\u00f6pf E (1996) Epidemiology of erythema exsudativum multiforme majus (EEMM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Germany (1990\u20131992). Structure and results of a\u00a0population-based registry. J\u00a0Clin Epidemiol 49:769\u2013773","journal-title":"J Clin Epidemiol"},{"key":"4153_CR35","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1365-2133.1997.tb03667.x","volume":"136","author":"TG Salopek","year":"1997","unstructured":"Salopek TG (1997) Nikolsky\u2019s sign: is it \u2018dry\u2019 or is it \u2018wet\u2019? Br J Dermatol 136:762\u2013767","journal-title":"Br J Dermatol"},{"key":"4153_CR36","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1002\/1097-0142(195901\/02)12:1<164::AID-CNCR2820120122>3.0.CO;2-Y","volume":"12","author":"S Saltzstein","year":"1959","unstructured":"Saltzstein S, Ackerman L (1959) Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically malignant lymphomas. Cancer 12:164\u2013182","journal-title":"Cancer"},{"key":"4153_CR37","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ejca.2017.03.026","volume":"81","author":"S Saw","year":"2017","unstructured":"Saw S, Lee HY, Ng QS (2017) Pembrolizumab-induced Stevens-Johnson syndrome in non-melanoma patients. Eur J Cancer 81:237\u2013239","journal-title":"Eur J Cancer"},{"issue":"Suppl 7","key":"4153_CR38","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1528-1157.1998.tb01681.x","volume":"39","author":"RG Schlienger","year":"1998","unstructured":"Schlienger RG, Shapiro LE, Shear NH (1998) Lamotrigine-induced severe cutaneous adverse reactions. Epilepsia 39(Suppl 7):22\u201326","journal-title":"Epilepsia"},{"key":"4153_CR39","first-page":"107","volume-title":"Medical informatics, biostatistics and epidemiology for efficient health care and medical research: contributions from the 44th annual conference of the GMDS","author":"W Schr\u00f6der","year":"1999","unstructured":"Schr\u00f6der W, Mockenhaupt M, Schlingmann J, Schneck B, Hering O, Sch\u00f6pf E (1999) Clinical Re-classification of severe skin reactions and evaluation of their etiology in a\u00a0population-based registry. In: Victor N et al (Hrsg) Medical informatics, biostatistics and epidemiology for efficient health care and medical research: contributions from the 44th annual conference of the GMDS. Urban & Vogel, Heidelberg, S 107\u2013110"},{"key":"4153_CR40","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1172\/JCI113798","volume":"82","author":"NH Shear","year":"1988","unstructured":"Shear NH, Spielberg SP (1988) Anticonvulsant hypersensitivity syndrome: In vitro assessment of risk. J\u00a0Clin Invest 82:1826\u20131832","journal-title":"J Clin Invest"},{"key":"4153_CR41","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000335624","volume":"97","author":"T Shiohara","year":"2012","unstructured":"Shiohara T, Kano Y, Takahashi R, Ishida T, Mizukawa Y (2012) Drug-induced hypersensitivity syndrome: recent advances in the diagnosis, pathogenesis and management. Chem Immunol Allergy 97:122\u2013138","journal-title":"Chem Immunol Allergy"},{"key":"4153_CR42","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1111\/bjd.13958","volume":"173","author":"R Sinha","year":"2015","unstructured":"Sinha R, Larkin J, Gore M, Fearfield L (2015) Cutaneous toxicities associated with vemurafenib therapy in 107 patients with BRAF V6ooE mutation-positive metastatic melanoma, including recognition and management of rare presentations. Br J Dermatol 173:1024\u20131031","journal-title":"Br J Dermatol"},{"key":"4153_CR43","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archpedi.1922.04120120077005","volume":"24","author":"AM Stevens","year":"1922","unstructured":"Stevens AM, Johnson FC (1922) A new eruptive fever associated with stomatitis and ophthalmia: report of two cases in children. Am J Dis Child 24:526\u2013533","journal-title":"Am J Dis Child"},{"key":"4153_CR44","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.radonc.2008.01.021","volume":"87","author":"L Valeyrie-Allanore","year":"2008","unstructured":"Valeyrie-Allanore L, Poulalhon N, Fagot JP, Sekula P, Davidovici B, Sidoroff A, Mockenhaupt M (2008) Stevens-Johnson syndrome and toxic epidermal necrolysis induced by amifostine during head and neck radiotherapy. Radiother Oncol 87:300\u2013303","journal-title":"Radiother Oncol"},{"key":"4153_CR45","volume-title":"Skin biopsy","author":"M Ziemer","year":"2011","unstructured":"Ziemer M, Mockenhaupt M (2011) Severe drug-induced skin reactions: clinical pattern, diagnostics and therapy. In: Khopkar U (Hrsg) Skin biopsy. InTech-Open Access Publisher, London (\n                    http:\/\/www.intechopen.com\/articles\/show\/title\/severe-drug-induced-skin-reactions-clinical-pattern-diagnostics-and-therapy\n                    \n                  )"},{"key":"4153_CR46","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1001\/archderm.143.6.711","volume":"143","author":"M Ziemer","year":"2007","unstructured":"Ziemer M, Wiesend CL, Vetter R, Weiss J, Blaschke S, Norgauer J, Mockenhaupt M (2007) Cutaneous adverse drug reactions to valdecoxib distinct from Stevens-Johnson syndrome and toxic epidermal necrolysis. Arch Dermatol 143:711\u2013716","journal-title":"Arch Dermatol"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00105-018-4153-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-018-4153-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-018-4153-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T01:14:03Z","timestamp":1553217243000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00105-018-4153-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["4153"],"URL":"https:\/\/doi.org\/10.1007\/s00105-018-4153-2","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"value":"0017-8470","type":"print"},{"value":"1432-1173","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,22]]},"assertion":[{"value":"22 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"M.\u00a0Mockenhaupt und M.\u00a0Paulmann geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Dieser Beitrag beinhaltet keine von den Autoren durchgef\u00fchrten Studien an Menschen oder Tieren. Alle Patienten, die \u00fcber Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben. Im Falle von nicht m\u00fcndigen Patienten liegt die Einwilligung eines Erziehungsberechtigten oder des gesetzlich bestellten Betreuers vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}