{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:34:29Z","timestamp":1773794069729,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Knappschaftskrankenhaus Bochum GmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec>\n<jats:title>Hintergrund<\/jats:title>\n<jats:p>Zur HIV(\u201ehuman immunodeficiency virus\u201c)-Pr\u00e4expositionsprophylaxe (PrEP) wird am WIR \u2013 Walk In Ruhr \u2013 Zentrum f\u00fcr Sexuelle Gesundheit und Medizin ein innovatives Modellprojekt zur intersektoralen PrEP-Versorgung durchgef\u00fchrt.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Forschungsziele<\/jats:title>\n<jats:p>Die vorliegende Studie beschreibt, wer mit der PrEP versorgt wurde und wie sich im Verlauf der PrEP-Einnahme das sexuelle Risikoverhalten \u00e4nderte sowie welche sexuell \u00fcbertragbaren Infektionen (STI) und unerw\u00fcnschte Arzneimittelwirkungen auftraten.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methoden<\/jats:title>\n<jats:p>In die Studie wurden bisher <jats:italic>N<\/jats:italic>\u202f=\u2009139\u00a0Probanden eingeschlossen, die zwischen 10\/2017 und 12\/2018 mit einer PrEP begonnen haben. Alle PrEP-Nutzer erhielten Frageb\u00f6gen, zudem wurden Nebenwirkungen, HIV und andere STI mittels klinischer Laborwerte \u00fcber einen Zeitraum von 13\u00a0Monaten erfasst.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Ergebnisse<\/jats:title>\n<jats:p>Die PrEP-Nutzer hatten ein durchschnittliches Alter von 38\u00a0Jahren, waren zu 98,6\u202f% M\u00e4nner, die Sex mit M\u00e4nnern (MSM) hatten, und zeichneten sich durch einen hohen Bildungsstatus und geringe Arbeitslosigkeit aus. Die durchschnittliche Partneranzahl pro Proband innerhalb der letzten 6\u00a0Monate stieg im Verlauf signifikant an, w\u00e4hrend die Kondomnutzung signifikant zur\u00fcckging. Innerhalb der ersten 4\u00a0Monate nach PrEP-Beginn traten 44\u00a0STI bei 34\u00a0Patienten auf. Es wurde keine HIV-Infektion festgestellt. In den ersten 4\u00a0Wochen nach PrEP-Beginn zeigten sich bei 38,8\u202f% der Probanden unerw\u00fcnschte Arzneimittelwirkungen, haupts\u00e4chlich Symptome des Magen-Darm-Trakts.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Schlussfolgerung<\/jats:title>\n<jats:p>Die PrEP-Nutzer hatten einen guten Bildungsstatus und einen festen Arbeitsplatz bzw. eine Ausbildungsstelle. Das sexuelle Risikoverhalten nahm im Verlauf zu, verbunden mit einem geh\u00e4uften Auftreten von STI. Unerw\u00fcnschte Arzneimittelwirkungen zeigten sich insbesondere zu Anfang der PrEP-Einnahme.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00105-020-04545-y","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T18:10:27Z","timestamp":1583259027000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["HIV-Pr\u00e4expositionsprophylaxe-Versorgung in intersektoraler Zusammenarbeit","HIV pre-exposure prophylaxis care in intersectoral collaboration"],"prefix":"10.1007","volume":"71","author":[{"given":"Patrick","family":"Ahaus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Potthoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Kayser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Wach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert H.","family":"Brockmeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane","family":"Skaletz-Rorowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"4545_CR1","unstructured":"UNAIDS Joint United Nations Programme on HIV\/AIDS (2019) UNAIDS data 2019. https:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/2019-UNAIDS-data_en.pdf. 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P.\u00a0Ahaus, A.\u00a0Potthoff, A.\u00a0Kayser, J.\u00a0Wach, N.H.\u00a0Brockmeyer und A.\u00a0Skaletz-Rorowski geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen oder an menschlichem Gewebe wurden mit Zustimmung der zust\u00e4ndigen Ethikkommission, im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}