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Wiederholt wurde in diesem Kontext \u00fcber die unzureichende Evidenz von Wundheilungsprodukten diskutiert. An dem Beispiel von TLC(\u201etechnology lipido-colloid\u201c)-Sucrose Octasulfat wird in der vorliegenden \u00dcbersichtsarbeit gezeigt, dass auch in diesem Bereich eine aussagekr\u00e4ftige Datenlage mit guter Evidenz und Vergleichbarkeit vorliegt. Ein therapeutischer Ansatzpunkt, die Wundheilung zu f\u00f6rdern, ist die Hemmung von Matrixmetalloproteinasen beispielsweise durch Sucrose Octasulfat. F\u00fcr Wundprodukte mit TLC-Sucrose Octasulfat wurden in den letzten Jahren mehrere, aufeinander aufbauende klinische Studien durchgef\u00fchrt. Die WHAT-Studie war eine offene RCT (randomisierte kontrollierte Studie) mit 117\u00a0Patienten mit Ulcus cruris venosum. Bei der CHALLENGE-Studie handelte es ich um eine doppelblind durchgef\u00fchrte RCT mit 187\u00a0Patienten mit Ulcus cruris venosum. Die SPID-Studie war eine Pilotstudie mit 33\u00a0Patienten mit diabetischem Fu\u00dfulkus (DFU). In 2 prospektiven, multizentrischen klinischen Pilotstudien NEREIDES und CASSIOPEE wurden insgesamt 88\u00a0Patienten mit Ulcera crurum in verschiedenen Heilungsphasen untersucht. In der REALITY-Studie erfolgte eine gepoolte Datenanalyse \u00fcber 8\u00a0Anwenderbeobachtungen mit 10.220\u00a0Patienten mit chronischen Wunden unterschiedlicher Genese. In der doppelblinden, zweiarmigen EXPLORER-RCT wurden 240\u00a0Patienten mit neuroisch\u00e4mischem DFU erstmalig bis zur vollst\u00e4ndigen Abheilung untersucht. In allen Studien konnte eine signifikante F\u00f6rderung der Wundheilung durch den Einsatz von Wundheilungsprodukten mit TLC-Sucrose Octasulfat gezeigt werden.<\/jats:p>","DOI":"10.1007\/s00105-020-04637-9","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T09:03:31Z","timestamp":1594112611000},"page":"791-801","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sucrose Octasulfat \u2013 Evidenz in der Behandlung chronischer Wunden","Sucrose octasulfate\u2014evidence in the treatment of chronic wounds"],"prefix":"10.1007","volume":"71","author":[{"given":"Joachim","family":"Dissemond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dietlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winfried","family":"Keuthage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severin","family":"L\u00e4uchli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Lobmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Christian","family":"M\u00fcnter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"St\u00fccker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Traber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Vanscheidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Strohal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"4637_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/iwj.12238","volume":"13","author":"M Augustin","year":"2016","unstructured":"Augustin\u00a0M, Herberger\u00a0K, Kr\u00f6ger\u00a0K et al (2016) Cost-effectiveness of treating vascular leg ulcers with UrgoStart\u00ae and UrgoCell\u00ae Contact. 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Small. https:\/\/doi.org\/10.1002\/smll.201703509","journal-title":"Small"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-020-04637-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-020-04637-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-020-04637-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T11:57:36Z","timestamp":1723204656000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-020-04637-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["4637"],"URL":"https:\/\/doi.org\/10.1007\/s00105-020-04637-9","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"type":"print","value":"0017-8470"},{"type":"electronic","value":"1432-1173"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"assertion":[{"value":"7 July 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"J.\u00a0Dissemond gibt folgende Interessenkonflikte an: Convatec, Coloplast, Engelhardt, KCI, Lohmann & Rauscher, Medi, M\u00f6lnlycke, SastoMed, Uluru sowie Urgo. M.\u00a0Augustin gibt folgende Interessenkonflikte an: 3M, AOK Bundesverband, Bayer Healthcare, Beiersdorf, Birken, Bode, B. Braun, BSN, BVmed, Coloplast, DAK, Diabet concept, Gerromed, GlaxoSmithKline, Johnson & Johnson, Lohmann & Rauscher, Medi, Medovent, M\u00f6lnlycke, Smith & Nephew, Sch\u00fclke & Mayr, S\u00f6ring, Sorbion, Systagenix sowie Urgo. W.\u00a0Keuthage gibt folgenden Interessenkonflikt an: Urgo. S.\u00a0L\u00e4uchli gibt folgende Interessenkonflikte an: Abbvie, Bristol-Myers-Squibb Mimedex, Sastomed, Roche, Galderma, Meda, Wound check, Ebi-Pharm sowie Urgo. R.\u00a0Lobmann gibt folgende Interessenkonflikte an: Amgen, Astra Zeneca, Biotec, B\u00f6hringer Ingelheim, GWT-TUD, Lilly, Medac MSD Sharp & Domme, M\u00f6lnlycke, Novo Nordisk, Roche, Sanofi Aventis, Sciaric, Urgo sowie W\u00f6rwag Pharma. K.-C.\u00a0M\u00fcnter gibt folgenden Interessenkonflikt an: Urgo. M.\u00a0St\u00fccker gibt folgende Interessenkonflikte an: Bauerfeind, Juzo, M\u00f6lnlycke, Sigvaris sowie Urgo. J.\u00a0Traber gibt folgenden Interessenkonflikt an: Urgo. W.\u00a0Vanscheidt gibt folgende Interessenkonflikte an: Marizyme, SkinDeep Technology, Elastimed, Lysan, Novartis, Lilly, Julia Therapeutics, QR Skin sowie Urgo. R.\u00a0Strohal gibt folgende Interessenkonflikte an: Pfizer, Sch\u00fclke & Mayer, Lohmann & Rauscher, Meda, Menarini, Stockhausen, Smith & Nephew, SastoMed, Novartis, Flen Pharma, APR, Urgo, Chemomedica, Pantec, 3M sowie Enjo Commercials. M.\u00a0Dietlein gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}