{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:54:08Z","timestamp":1648972448792},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Private Universit\u00e4t Witten\/Herdecke gGmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Beim Lichen planus handelt es sich vermutlich um eine chronisch inflammatorische, immunologisch induzierte mukokutane Dermatose. Der Lichen planus mucosae manifestiert sich am h\u00e4ufigsten in der Mundh\u00f6hle. Diverse Triggerfaktoren wie bakterielle oder virale Infektionen, Medikamente oder physikalische Reize werden bei der Entstehung der Erkrankung diskutiert. Auch eine Assoziation mit Infektionen durch humane Papillomviren wurde beschrieben, ein kausaler Zusammenhang ist jedoch nicht hinreichend belegt. Als fakultative Pr\u00e4kanzerose kann sich auf dem Boden eines Lichen planus mucosae ein Plattenepithelkarzinom entwickeln, die maligne Transformationsrate ist aber gering. Das Risiko der malignen Transformation ist signifikant erh\u00f6ht bei Patienten mit oralem Lichen planus, die rauchen, vermehrt Alkohol konsumieren oder an Hepatitis\u00a0C erkrankt sind. Wir beschreiben 2\u00a0Patienten, bei denen sich lokal fortgeschrittene Plattenepithelkarzinome auf dem Boden eines langj\u00e4hrig bestehenden oralen Lichen planus entwickelten. Beide F\u00e4lle wurden erfolgreich durch radikale Tumorresektion mit anschlie\u00dfender Rekonstruktion und adjuvanter Radiatio\/Radiochemotherapie behandelt.<\/jats:p>","DOI":"10.1007\/s00105-020-04669-1","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T19:02:26Z","timestamp":1597950146000},"page":"1000-1006","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plattenepithelkarzinom auf dem Boden eines oralen Lichen planus"],"prefix":"10.1007","volume":"71","author":[{"given":"Bijan","family":"Koushk-Jalali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svenja","family":"Sch\u00fcrrle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kuntz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Mitrakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Tigges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Oellig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hammacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffi","family":"Silling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Kreuter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,20]]},"reference":[{"key":"4669_CR1","doi-asserted-by":"publisher","first-page":"e427","DOI":"10.4317\/medoral.18356","volume":"18","author":"B G\u00fcmr\u00fc","year":"2013","unstructured":"G\u00fcmr\u00fc\u00a0B (2013) A retrospective study of 370 patients with oral lichen planus in Turkey. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patienten zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}