{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T09:10:21Z","timestamp":1724577021159},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Hautarzt"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s00105-021-04777-6","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T18:42:50Z","timestamp":1614796970000},"page":"295-298","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hyperplasie-assoziierte obligate Paraneoplasien der Haut","Hyperplasia-associated cutaneous paraneoplasia"],"prefix":"10.1007","volume":"72","author":[{"given":"Morna F.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurenz C.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"4777_CR1","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1001\/archderm.1967.01600320058010","volume":"95","author":"AB Ackerman","year":"1967","unstructured":"Ackerman\u00a0AB, Lantis\u00a0LR (1967) Acanthosis nigricans associated with Hodgkin\u2019s disease. Concurrent remission and exacerbation. Arch Dermatol 95:202\u2013205","journal-title":"Arch Dermatol"},{"key":"4777_CR2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1365-2133.1980.tb07248.x","volume":"103","author":"A Bazex","year":"1980","unstructured":"Bazex\u00a0A, Griffiths\u00a0A (1980) Acrokeratosis paraneoplastica\u2014a new cutaneous marker of malignancy. Br J Dermatol 103:301\u2013306","journal-title":"Br J Dermatol"},{"key":"4777_CR3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/00005792-199107000-00004","volume":"70","author":"JL Bolognia","year":"1991","unstructured":"Bolognia\u00a0JL, Brewer\u00a0YP, Cooper\u00a0DL (1991) Bazex syndrome (acrokeratosis paraneoplastica). An analytic review. Medicine (Baltimore) 70:269\u2013280","journal-title":"Medicine (Baltimore)"},{"key":"4777_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/b137790","volume-title":"Dermatologie und Venerologie","author":"O Braun-Falco","year":"2005","unstructured":"Braun-Falco\u00a0O, Plewig\u00a0G, Wolff\u00a0HH et al (2005) Dermatologie und Venerologie"},{"key":"4777_CR5","first-page":"802","volume":"91","author":"T Chiba","year":"1996","unstructured":"Chiba\u00a0T, Shitomi\u00a0T, Nakano\u00a0O et al (1996) The sign of Leser-Trelat associated with esophageal carcinoma. Am J Gastroenterol 91:802\u2013804","journal-title":"Am J Gastroenterol"},{"key":"4777_CR6","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/328817a0","volume":"328","author":"RJ Coffey Jr","year":"1987","unstructured":"Coffey\u00a0RJ Jr, Derynck\u00a0R, Wilcox\u00a0JN et al (1987) Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature 328:817\u2013820","journal-title":"Nature"},{"key":"4777_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1001\/archderm.1948.01520140020003","volume":"57","author":"HO Curth","year":"1948","unstructured":"Curth\u00a0HO (1948) Acanthosis nigricans and its association with cancer. Arch Derm Syphilol 57:158\u2013170","journal-title":"Arch Derm Syphilol"},{"key":"4777_CR8","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1067\/j.cpsurg.2010.01.003","volume":"47","author":"BD Ehst","year":"2010","unstructured":"Ehst\u00a0BD, Minzer-Conzetti\u00a0K, Swerdlin\u00a0A et al (2010) Cutaneous manifestations of internal malignancy. Curr Probl Surg 47:384\u2013445","journal-title":"Curr Probl Surg"},{"key":"4777_CR9","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1056\/NEJM198712173172506","volume":"317","author":"DL Ellis","year":"1987","unstructured":"Ellis\u00a0DL, Kafka\u00a0SP, Chow\u00a0JC et al (1987) Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Tr\u00e9lat, and multiple acrochordons. A possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N\u00a0Engl J Med 317:1582\u20131587","journal-title":"N Engl J Med"},{"key":"4777_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-53647-6","volume-title":"Dermatologie Venerologie","author":"P Fritsch","year":"2018","unstructured":"Fritsch\u00a0P, Schwartz\u00a0T (2018) Dermatologie Venerologie. Spinger, Berlin, Heidelberg"},{"key":"4777_CR11","first-page":"42","volume":"6","author":"T Funakawa","year":"1994","unstructured":"Funakawa\u00a0T, Fujishiro\u00a0N (1994) Colon cancer with the sign of Leser-Tr\u00e9lat. Ryoikibetsu Shokogun Shirizu 6:42\u201344","journal-title":"Ryoikibetsu Shokogun Shirizu"},{"key":"4777_CR12","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1067\/mjd.2000.104967","volume":"43","author":"MR Heaphy Jr","year":"2000","unstructured":"Heaphy\u00a0MR Jr, Millns\u00a0JL, Schroeter\u00a0AL (2000) The sign of Leser-Tr\u00e9lat in a\u00a0case of adenocarcinoma of the lung. J\u00a0Am Acad Dermatol 43:386\u2013390","journal-title":"J Am Acad Dermatol"},{"key":"4777_CR13","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0190-9622(88)80352-9","volume":"19","author":"MR Holdiness","year":"1988","unstructured":"Holdiness\u00a0MR (1988) On the classification of the sign of Leser-Tr\u00e9lat. J\u00a0Am Acad Dermatol 19:754\u2013757","journal-title":"J Am Acad Dermatol"},{"key":"4777_CR14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1055\/s-0029-1203939","volume":"26","author":"E Holl\u00e4nder","year":"1900","unstructured":"Holl\u00e4nder\u00a0E (1900) Beitr\u00e4ge zur Fr\u00fchdiagnose des Darmcarcinoms (Heredit\u00e4tsverh\u00e4ltnisse und Hautver\u00e4nderungen). Dtsch Med Wochenschr 26:483\u2013485","journal-title":"Dtsch Med Wochenschr"},{"key":"4777_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00428-013-1503-4","volume":"464","author":"RK Jepsen","year":"2014","unstructured":"Jepsen\u00a0RK, Skov\u00a0AG, Skov\u00a0BG (2014) Leser-Tr\u00e9lat syndrome in malignant mesothelioma and pulmonary adenocarcinoma: Is the EGFR pathway part of the syndrome? Virchows Arch 464:117\u2013120","journal-title":"Virchows Arch"},{"key":"4777_CR16","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/BF01213299","volume":"32","author":"S Koyama","year":"1997","unstructured":"Koyama\u00a0S, Ikeda\u00a0K, Sato\u00a0M et al (1997) Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus. J\u00a0Gastroenterol 32:71\u201377","journal-title":"J Gastroenterol"},{"key":"4777_CR17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.20452\/pamw.642","volume":"119","author":"M Krawczyk","year":"2009","unstructured":"Krawczyk\u00a0M, Myka\u0142a-Cie\u015bla\u00a0J, Ko\u0142odziej-Jasku\u0142a\u00a0A (2009) Acanthosis nigricans as a\u00a0paraneoplastic syndrome. Case reports and review of literature. Pol Arch Med Wewn 119:180\u2013183","journal-title":"Pol Arch Med Wewn"},{"key":"4777_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s001050050699","volume":"49","author":"U Lenzner","year":"1998","unstructured":"Lenzner\u00a0U, Raumsauer\u00a0J, Petzoldt\u00a0W et\u00a0al (1998) Acanthosis nigricans maligna Fallbeschreibung und Literatur\u00fcbersicht. Hautarzt 49:41\u201347","journal-title":"Hautarzt"},{"key":"4777_CR19","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/S0190-9622(98)70143-4","volume":"38","author":"ML McCrary","year":"1998","unstructured":"McCrary\u00a0ML, Davis\u00a0LS (1998) Sign of Leser-Tr\u00e9lat and mycosis fungoides. J\u00a0Am Acad Dermatol 38:644","journal-title":"J Am Acad Dermatol"},{"key":"4777_CR20","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.1365-2230.1976.tb01443.x","volume":"1","author":"LG Millard","year":"1976","unstructured":"Millard\u00a0LG, Gould\u00a0DJ (1976) Hyperkeratosis of the palms and soles associated with internal malignancy and elevated levels of immunoreactive human growth hormone. Clin Exp Dermatol 1:363\u2013368","journal-title":"Clin Exp Dermatol"},{"key":"4777_CR21","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1053\/jd.1999.v40.a95652","volume":"40","author":"DF Mutasim","year":"1999","unstructured":"Mutasim\u00a0DF, Meiri\u00a0G (1999) Bazex syndrome mimicking a\u00a0primary autoimmune bullous disorder. J\u00a0Am Acad Dermatol 40:822\u2013825","journal-title":"J Am Acad Dermatol"},{"key":"4777_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.det.2007.08.002","volume":"26","author":"CA Pipkin","year":"2008","unstructured":"Pipkin\u00a0CA, Lio\u00a0PA (2008) Cutaneous manifestations of internal malignancies: an overview. Dermatol Clin 26:1\u201315","journal-title":"Dermatol Clin"},{"key":"4777_CR23","first-page":"4133","volume":"17","author":"ML Popa","year":"2019","unstructured":"Popa\u00a0ML, Popa\u00a0AC, Tanase\u00a0C et\u00a0al (2019) Acanthosis nigricans: to be or not to be afraid. Oncol Lett 17:4133\u20134138","journal-title":"Oncol Lett"},{"key":"4777_CR24","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1001\/archderm.1978.01640240045015","volume":"114","author":"RA Schwartz","year":"1978","unstructured":"Schwartz\u00a0RA, Burgess\u00a0GH (1978) Florid cutaneous papillomatosis. Arch Dermatol 114:1803\u20131806","journal-title":"Arch Dermatol"},{"key":"4777_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1590\/S0365-05962013000100001","volume":"88","author":"JA da Silva","year":"2013","unstructured":"da Silva\u00a0JA, de Carvalho Mesquita\u00a0K, de Souza Machado Igreja\u00a0AC et\u00a0al (2013) Paraneoplastic cutaneous manifestations: concepts and updates. An Bras Dermatol 88:9\u201322","journal-title":"An Bras Dermatol"},{"key":"4777_CR26","first-page":"344","volume":"62","author":"W Stieler","year":"1986","unstructured":"Stieler\u00a0W, Plewig\u00a0C (1986) Acanthosis nigricans maligna and Leser-Tr\u00e9lat Zeichen bei Doppelmalignom von Mamma und Magen. Z\u00a0Hautkr 62:344\u2013366","journal-title":"Z Hautkr"},{"key":"4777_CR27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1515\/JBCPP.1998.9.2-4.407","volume":"9","author":"CA Stuart","year":"1998","unstructured":"Stuart\u00a0CA, Driscoll\u00a0MS, Lundquist\u00a0KF et\u00a0al (1998) Acanthosis nigricans. J\u00a0Basic Clin Physiol Pharmacol 9:407\u2013418","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"4777_CR28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF01612665","volume":"116","author":"E Tahara","year":"1990","unstructured":"Tahara\u00a0E (1990) Growth factors and oncogenes in human gastrointestinal carcinomas. J\u00a0Cancer Res Clin Oncol 116:121\u2013131","journal-title":"J Cancer Res Clin Oncol"},{"key":"4777_CR29","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1046\/j.1365-2133.2002.05150.x","volume":"147","author":"D Torley","year":"2002","unstructured":"Torley\u00a0D, Bellus\u00a0GA, Munro\u00a0CS (2002) Genes, growth factors and acanthosis nigricans. Br J Dermatol 147:1096\u20131101","journal-title":"Br J Dermatol"},{"key":"4777_CR30","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1346-8138.1996.tb03996.x","volume":"23","author":"T Yamamoto","year":"1996","unstructured":"Yamamoto\u00a0T, Yokoyama\u00a0A (1996) Hereditary onset of multiple seborrheic keratoses: a\u00a0variant of Leser Tr\u00e9lat sign? J\u00a0Dermatol 23:191\u2013195","journal-title":"J Dermatol"}],"container-title":["Der Hautarzt"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-021-04777-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00105-021-04777-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-021-04777-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T08:09:46Z","timestamp":1724573386000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00105-021-04777-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["4777"],"URL":"https:\/\/doi.org\/10.1007\/s00105-021-04777-6","relation":{},"ISSN":["0017-8470","1432-1173"],"issn-type":[{"type":"print","value":"0017-8470"},{"type":"electronic","value":"1432-1173"}],"subject":[],"published":{"date-parts":[[2021,3,3]]},"assertion":[{"value":"2 February 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"M.F.\u00a0Schmidt, M.\u00a0Schaller und L.C.\u00a0Schmitt geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. Alle Patienten, die \u00fcber Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts zu identifizieren sind, haben hierzu ihre schriftliche Einwilligung gegeben.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}