{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T04:44:44Z","timestamp":1762058684457,"version":"build-2065373602"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Martin-Luther-Universit\u00e4t Halle-Wittenberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Mamillenregion ist durch besondere anatomische Verh\u00e4ltnisse charakterisiert und l\u00e4sst sich aus dermatologischer Perspektive in Brusthaut, Haut des Brustwarzenhofes (Areola) und Haut der Brustwarze (Papilla mammae) unterteilen. Im klinischen Zusammenhang sind die Brustwarzen h\u00e4ufig w\u00e4hrend der Stillzeit durch mechanische Beanspruchung, Milieu\u00e4nderung mit Mazeration durch den Milchfluss sowie durch mikrobielle Erreger alteriert. Zudem besteht hier die Gefahr der Entwicklung einer Mastitis puerperalis. Au\u00dferhalb der Schwangerschaft und Stillzeit finden sich gelegentlich an der Mamillenhaut Ekzemerkrankungen, h\u00e4ufig bei atopischer Disposition (atopisches Mamillenekzem) oder als irritatives Kontaktekzem (\u201ejoggers nipple\u201c). Seltener werden allergische Kontaktekzeme auf Konservierungsstoffe von Topika oder Metallen (Piercings) beobachtet. Auch im Rahmen einer Skabiesinfestation wird eine Beteiligung der Mamillen, insbesondere bei Frauen, regelm\u00e4\u00dfig beobachtet. Von gro\u00dfer klinischer Bedeutung sind seltene, pr\u00e4invasive L\u00e4sionen eines Mammakarzinoms oder der Morbus Paget der Mamille vom extramamm\u00e4ren Typ. Durch die besonderen anatomischen Gegebenheiten ist es naheliegend, dass bei der Anwendung von Topika sich auch spezifische Penetrationsbedingungen ableiten. Experimentelle Untersuchungen an Humanhaut ex vivo legen nahe, dass in Abh\u00e4ngigkeit von der Molmasse und der L\u00f6slichkeit des Arzneistoffs sowie des eingesetzten Vehikelsystems eine deutliche Zunahme der kutanen Bioverf\u00fcgbarkeit, insbesondere an der Brustwarze selbst durch den transpapill\u00e4ren Diffusionsweg, auftreten kann. Dies sollte insbesondere bei der topischen Anwendung von Arzneistoffen mit bekanntem dosisabh\u00e4ngigem Nebenwirkungspotenzial (z.\u202fB. Glukokortikoiden) beachtet werden. Allerdings fehlt daf\u00fcr bisher eine klinische Evidenz.<\/jats:p>","DOI":"10.1007\/s00105-022-05031-3","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T16:07:57Z","timestamp":1657642077000},"page":"873-879","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutische Besonderheiten bei Erkrankungen der Mamillenhaut","Therapeutic peculiarities in diseases of the nipple skin"],"prefix":"10.1007","volume":"73","author":[{"given":"Thanh Huong","family":"Luu Thi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina","family":"Eichner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Wohlrab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"5031_CR1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/j.1365-2559.2011.03792.x","volume":"58","author":"S Moritani","year":"2011","unstructured":"Moritani\u00a0S, Ichihara\u00a0S, Hasegawa\u00a0M, Endo\u00a0T, Oiwa\u00a0M, Shiraiwa\u00a0M, Nishida\u00a0C, Morita\u00a0T, Sato\u00a0Y, Hayashi\u00a0T, Kato\u00a0A, Aoyama\u00a0H, Yoshikawa\u00a0K (2011) Topographical, morphological and immunohistochemical characteristics of carcinoma in situ of the breast involving sclerosing adenosis. Two distinct topographical patterns and histological types of carcinoma in situ. Histopathology 58:835\u2013846","journal-title":"Histopathology"},{"key":"5031_CR2","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/cncr.20559","volume":"101","author":"SM Love","year":"2004","unstructured":"Love\u00a0SM, Barsky\u00a0SH (2004) Anatomy of the nipple and breast ducts revisited. Cancer 101:1947\u20131957","journal-title":"Cancer"},{"key":"5031_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/GRF.0b013e318207ffe9","volume":"54","author":"S Pandya","year":"2011","unstructured":"Pandya\u00a0S, Moore\u00a0RG (2011) Breast development and anatomy. Clin Obstet Gynecol 54:91\u201395","journal-title":"Clin Obstet Gynecol"},{"key":"5031_CR4","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.jaad.2018.08.066","volume":"80","author":"RA Waldman","year":"2019","unstructured":"Waldman\u00a0RA, Finch\u00a0J, Grant-Kels\u00a0JM, Stevenson\u00a0C, Whitaker-Worth\u00a0D (2019) Skin diseases of the breast and nipple: benign and malignant tumors. J\u00a0Am Acad Dermatol 80:1467\u20131481","journal-title":"J Am Acad Dermatol"},{"key":"5031_CR5","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1148\/rg.292085128","volume":"29","author":"BT Nicholson","year":"2009","unstructured":"Nicholson\u00a0BT, Harvey\u00a0JA, Cohen\u00a0MA (2009) Nipple-areolar complex: normal anatomy and benign and malignant processes. Radiographics 29:509\u2013523","journal-title":"Radiographics"},{"key":"5031_CR6","first-page":"32","volume":"5","author":"G Zucca-Matthes","year":"2016","unstructured":"Zucca-Matthes\u00a0G, Urban\u00a0C, Vallejo\u00a0A (2016) Anatomy of the nipple and breast ducts. Gland Surg 5:32\u201336","journal-title":"Gland Surg"},{"key":"5031_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1053\/j.tvir.2013.12.002","volume":"17","author":"RA Jesinger","year":"2014","unstructured":"Jesinger\u00a0RA (2014) Breast anatomy for the interventionalist. Tech Vasc Interv Radiol 17:3\u20139","journal-title":"Tech Vasc Interv Radiol"},{"key":"5031_CR8","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1113\/expphysiol.1996.sp003985","volume":"81","author":"DB Cox","year":"1996","unstructured":"Cox\u00a0DB, Owens\u00a0RA, Hartmann\u00a0PE (1996) Blood and milk prolactin and the rate of milk synthesis in women. Exp Physiol 81:1007\u20131020","journal-title":"Exp Physiol"},{"key":"5031_CR9","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1067\/mjd.2000.109303","volume":"43","author":"DL Whitaker-Worth","year":"2000","unstructured":"Whitaker-Worth\u00a0DL, Carlone\u00a0V, Susser\u00a0WS, Phelan\u00a0N, Grant-Kels\u00a0JM (2000) Dermatologic diseases of the breast and nipple. J\u00a0Am Acad Dermatol 43:733\u2013751 (quiz 752\u2013734)","journal-title":"J Am Acad Dermatol"},{"key":"5031_CR10","volume-title":"Breast imaging","author":"DB Kopans","year":"2007","unstructured":"Kopans\u00a0DB (2007) Breast imaging, 3.\u00a0Aufl. Lippincott Williams & Wilkins, Baltimore, MD","edition":"3"},{"key":"5031_CR11","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1245\/s10434-015-4760-4","volume":"22","author":"K Stone","year":"2015","unstructured":"Stone\u00a0K, Wheeler\u00a0A (2015) A review of anatomy, physiology, and benign pathology of the nipple. Ann Surg Oncol 22:3236\u20133240","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"5031_CR12","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1148\/rg.27si075512","volume":"27","author":"D Da Costa","year":"2007","unstructured":"Da Costa\u00a0D, Taddese\u00a0A, Cure\u00a0ML, Gerson\u00a0D, Poppiti\u00a0R Jr., Esserman\u00a0LE (2007) Common and unusual diseases of the nipple-areolar complex. Radiographics 27(1):S65\u201377","journal-title":"Radiographics"},{"key":"5031_CR13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/00015550410024878","volume":"84","author":"H Blech","year":"2004","unstructured":"Blech\u00a0H, Friebe\u00a0K, Krause\u00a0W (2004) Inflammation of montgomery glands. Acta Derm Venereol 84:93\u201394","journal-title":"Acta Derm Venereol"},{"key":"5031_CR14","first-page":"1004","volume":"9","author":"W Krause","year":"2011","unstructured":"Krause\u00a0W (2011) Diseases of the male nipple and areola. J\u00a0Dtsch Dermatol Ges 9:1004\u20131009","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"5031_CR15","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.jaad.2018.08.067","volume":"80","author":"RA Waldman","year":"2019","unstructured":"Waldman\u00a0RA, Finch\u00a0J, Grant-Kels\u00a0JM, Whitaker-Worth\u00a0D (2019) Skin diseases of the breast and nipple: inflammatory and infectious diseases. J\u00a0Am Acad Dermatol 80:1483\u20131494","journal-title":"J Am Acad Dermatol"},{"key":"5031_CR16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.5021\/ad.2014.26.3.413","volume":"26","author":"SK Kim","year":"2014","unstructured":"Kim\u00a0SK, Won\u00a0YH, Kim\u00a0S\u2011J (2014) Nipple eczema: a diagnostic challenge of allergic contact dermatitis. Ann Dermatol 26:413\u2013414","journal-title":"Ann Dermatol"},{"key":"5031_CR17","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3238\/arztebl.m2021.0296","volume":"118","author":"C Sunderkotter","year":"2021","unstructured":"Sunderkotter\u00a0C, Wohlrab\u00a0J, Hamm\u00a0H (2021) Scabies: epidemiology, diagnosis, and treatment. Dtsch Arztebl Int 118:695\u2013704. https:\/\/doi.org\/10.3238\/arztebl.m2021.0296","journal-title":"Dtsch Arztebl Int"},{"key":"5031_CR18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1177\/089033449901500315","volume":"15","author":"V Livingstone","year":"1999","unstructured":"Livingstone\u00a0V, Stringer\u00a0LJ (1999) The treatment of staphyloccocus aureus infected sore nipples: a randomized comparative study. J\u00a0Hum Lact 15:241\u2013246","journal-title":"J Hum Lact"},{"key":"5031_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1177\/0890334409349806","volume":"26","author":"LJ Kvist","year":"2010","unstructured":"Kvist\u00a0LJ (2010) Toward a\u00a0clarification of the concept of mastitis as used in empirical studies of breast inflammation during lactation. J\u00a0Hum Lact 26:53\u201359","journal-title":"J Hum Lact"},{"key":"5031_CR20","volume-title":"Leitlinie der Deutschen Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe (AWMF 015\/071): Therapie entz\u00fcndlicher Brusterkrankungen in der Stillzeit","author":"Leitliniengruppe","year":"2013","unstructured":"Leitliniengruppe (2013) Leitlinie der Deutschen Gesellschaft f\u00fcr Gyn\u00e4kologie und Geburtshilfe (AWMF 015\/071): Therapie entz\u00fcndlicher Brusterkrankungen in der Stillzeit"},{"key":"5031_CR21","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-3-030-41596-9_7","volume":"1252","author":"R Omranipour","year":"2020","unstructured":"Omranipour\u00a0R, Vasigh\u00a0M (2020) Mastitis, breast abscess, and granulomatous mastitis. Adv Exp Med Biol 1252:53\u201361","journal-title":"Adv Exp Med Biol"},{"key":"5031_CR22","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1007\/s12262-012-0776-1","volume":"75","author":"K Kataria","year":"2013","unstructured":"Kataria\u00a0K, Srivastava\u00a0A, Dhar\u00a0A (2013) Management of lactational mastitis and breast abscesses: review of current knowledge and practice. Indian J Surg 75:430\u2013435","journal-title":"Indian J Surg"},{"key":"5031_CR23","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1097\/00000421-200108000-00019","volume":"24","author":"W Fu","year":"2001","unstructured":"Fu\u00a0W, Mittel\u00a0VK, Young\u00a0SC (2001) Paget disease of the breast: analysis of 41\u00a0patients. Am J Clin Oncol 24:397\u2013400","journal-title":"Am J Clin Oncol"},{"key":"5031_CR24","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00292-020-00772-1","volume":"41","author":"A Streng","year":"2020","unstructured":"Streng\u00a0A, Gutjahr\u00a0E, Aulmann\u00a0S, Flechtenmacher\u00a0C, Toberer\u00a0F, Heil\u00a0J, Bocker\u00a0W, Sinn\u00a0P (2020) Pathology of the nipple-areola complex : I. Paget\u2019s disease of the nipple, variants, and differential diagnoses. Pathologe 41:393\u2013399","journal-title":"Pathologe"},{"key":"5031_CR25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12895-016-0041-6","volume":"16","author":"GP Spohn","year":"2016","unstructured":"Spohn\u00a0GP, Trotter\u00a0SC, Tozbikian\u00a0G, Povoski\u00a0SP (2016) Nipple adenoma in a\u00a0female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. BMC Dermatol 16:4","journal-title":"BMC Dermatol"},{"key":"5031_CR26","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00292-020-00790-z","volume":"41","author":"E Gutjahr","year":"2020","unstructured":"Gutjahr\u00a0E, Streng\u00a0A, Aulmann\u00a0S, Flechtenmacher\u00a0C, Toberer\u00a0F, Heil\u00a0J, Bocker\u00a0W, Sinn\u00a0P (2020) Pathology of the nipple-areola complex : part ii. Tumors, tumor-like lesions, and supernumerary breast lesions. Pathologe 41:515\u2013522","journal-title":"Pathologe"},{"key":"5031_CR27","doi-asserted-by":"publisher","first-page":"379","DOI":"10.18176\/jiaci.0293","volume":"28","author":"A Sala-Cunill","year":"2018","unstructured":"Sala-Cunill\u00a0A, Lazaro\u00a0M, Herraez\u00a0L, Quinones\u00a0MD, Moro-Moro\u00a0M, Sanchez\u00a0I (2018) Skin allergy committee of Spanish society of A, clinical I: basic skin care and topical therapies for atopic dermatitis: essential approaches and beyond. J\u00a0Investig Allergol Clin Immunol 28:379\u2013391","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"7","key":"5031_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/ddg.13906","volume":"17","author":"M Augustin","year":"2019","unstructured":"Augustin\u00a0M, Wilsmann-Theis\u00a0D, Korber\u00a0A, Kerscher\u00a0M, Itschert\u00a0G, Dippel\u00a0M, Staubach\u00a0P (2019) Diagnosis and treatment of xerosis cutis\u2014a\u00a0position paper. J\u00a0Dtsch Dermatol Ges 17(7):3\u201333","journal-title":"J Dtsch Dermatol Ges"},{"key":"5031_CR29","first-page":"376","volume":"16","author":"J Wohlrab","year":"2018","unstructured":"Wohlrab\u00a0J, Staubach\u00a0P, Augustin\u00a0M, Eisert\u00a0L, Hunerbein\u00a0A, Nast\u00a0A, Reimann\u00a0H, Stromer\u00a0K, Mahler\u00a0V (2018) S2k-Leitlinie zum Gebrauch von Pr\u00e4parationen zur lokalen Anwendung auf der Haut (Topika). J\u00a0Dtsch Dermatol Ges 16:376\u2013392","journal-title":"J Dtsch Dermatol Ges"},{"key":"5031_CR30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1159\/000489519","volume":"54","author":"J Wohlrab","year":"2018","unstructured":"Wohlrab\u00a0J, Gebert\u00a0A, Neubert\u00a0RHH (2018) Lipids in the skin and ph. Curr Probl Dermatol 54:64\u201370","journal-title":"Curr Probl Dermatol"},{"key":"5031_CR31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000489526","volume":"54","author":"J Wohlrab","year":"2018","unstructured":"Wohlrab\u00a0J, Gebert\u00a0A (2018) Ph and buffer capacity of topical formulations. Curr Probl Dermatol 54:123\u2013131","journal-title":"Curr Probl Dermatol"},{"key":"5031_CR32","doi-asserted-by":"publisher","first-page":"28061","DOI":"10.1038\/srep28061","volume":"6","author":"AA Chan","year":"2016","unstructured":"Chan\u00a0AA, Bashir\u00a0M, Rivas\u00a0MN, Duvall\u00a0K, Sieling\u00a0PA, Pieber\u00a0TR, Vaishampayan\u00a0PA, Love\u00a0SM, Lee\u00a0DJ (2016) Characterization of the microbiome of nipple aspirate fluid of breast cancer survivors. Sci Rep 6:28061","journal-title":"Sci Rep"},{"key":"5031_CR33","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jhin.2009.08.022","volume":"74","author":"BV Krishna","year":"2010","unstructured":"Krishna\u00a0BV, Gibb\u00a0AP (2010) Use of octenidine dihydrochloride in meticillin-resistant staphylococcus aureus decolonisation regimens: a literature review. J\u00a0Hosp Infect 74:199\u2013203","journal-title":"J Hosp Infect"},{"key":"5031_CR34","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/cre2.386","volume":"7","author":"V Grover","year":"2021","unstructured":"Grover\u00a0V, Mahendra\u00a0J, Gopalakrishnan\u00a0D, Jain\u00a0A (2021) Effect of octenidine mouthwash on plaque, gingivitis, and oral microbial growth: a systematic review. Clin Exp Dent Res 7:450\u2013464","journal-title":"Clin Exp Dent Res"},{"key":"5031_CR35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1159\/000318264","volume":"23","author":"NO Hubner","year":"2010","unstructured":"Hubner\u00a0NO, Kramer\u00a0A (2010) Review on the efficacy, safety and clinical applications of polihexanide, a\u00a0modern wound antiseptic. Skin Pharmacol Physiol 23:17\u201327","journal-title":"Skin Pharmacol Physiol"},{"key":"5031_CR36","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.3233\/BD-219012","volume":"40","author":"R Nur","year":"2021","unstructured":"Nur\u00a0R, Nurul Fajriah\u00a0R, Larasati\u00a0RD, Dirpan\u00a0A, Rusydi\u00a0M (2021) Status of breast care during pregnancy with milk production and disease. Breast Dis 40:S85\u2013S89","journal-title":"Breast Dis"},{"key":"5031_CR37","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0266-6138(02)00102-X","volume":"19","author":"S Carfoot","year":"2003","unstructured":"Carfoot\u00a0S, Williamson\u00a0PR, Dickson\u00a0R (2003) A systematic review of randomised controlled trials evaluating the effect of mother\/baby skin-to-skin care on successful breast feeding. Midwifery 19:148\u2013155","journal-title":"Midwifery"},{"key":"5031_CR38","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.midw.2004.09.002","volume":"21","author":"S Carfoot","year":"2005","unstructured":"Carfoot\u00a0S, Williamson\u00a0P, Dickson\u00a0R (2005) A randomised controlled trial in the north of england examining the effects of skin-to-skin care on breast feeding. Midwifery 21:71\u201379","journal-title":"Midwifery"},{"key":"5031_CR39","first-page":"115","volume":"6","author":"J Wohlrab","year":"2014","unstructured":"Wohlrab\u00a0J, Bangemann\u00a0N, Kleine-Tebbe\u00a0A, Thill\u00a0M, Kummel\u00a0S, Grischke\u00a0EM, Richter\u00a0R, Seite\u00a0S, Luftner\u00a0D (2014) Barrier protective use of skin care to prevent chemotherapy-induced cutaneous symptoms and to maintain quality of life in patients with breast cancer. Breast Cancer (Dove Med Press) 6:115\u2013122","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"5031_CR40","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.2147\/CCID.S322228","volume":"14","author":"J Kondziolka","year":"2021","unstructured":"Kondziolka\u00a0J, Wilczynski\u00a0S (2021) Overview of the active ingredients in cosmetic products for the care of skin that has been exposed to ionizing radiation\u2014analysis of their effectiveness in breast cancer radiotherapy. Clin Cosmet Investig Dermatol 14:1065\u20131076","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"5031_CR41","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s00105-013-2654-6","volume":"65","author":"J Wohlrab","year":"2014","unstructured":"Wohlrab\u00a0J (2014) Grundlagen der topischen Therapie. Hautarzt 65:169\u2013174","journal-title":"Hautarzt"},{"key":"5031_CR42","first-page":"1061","volume":"14","author":"J Wohlrab","year":"2016","unstructured":"Wohlrab\u00a0J (2016) Topika und deren Einsatz in der Dermatologie. J\u00a0Dtsch Dermatol Ges 14:1061\u20131071","journal-title":"J Dtsch Dermatol Ges"},{"key":"5031_CR43","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/BF00685799","volume":"36","author":"H Pujol","year":"1995","unstructured":"Pujol\u00a0H, Girault\u00a0J, Rouanet\u00a0P, Fournier\u00a0S, Grenier\u00a0J, Simony\u00a0J, Fourtillan\u00a0JB, Pujol\u00a0JL (1995) Phase i study of percutaneous 4\u2011hydroxy-tamoxifen with analyses of 4\u2011hydroxy-tamoxifen concentrations in breast cancer and normal breast tissue. Cancer Chemother Pharmacol 36:493\u2013498","journal-title":"Cancer Chemother Pharmacol"},{"key":"5031_CR44","doi-asserted-by":"publisher","first-page":"e115712","DOI":"10.1371\/journal.pone.0115712","volume":"9","author":"K Dave","year":"2014","unstructured":"Dave\u00a0K, Averineni\u00a0R, Sahdev\u00a0P, Perumal\u00a0O (2014) Transpapillary drug delivery to the breast. PLoS One 9:e115712","journal-title":"PLoS One"},{"key":"5031_CR45","doi-asserted-by":"publisher","first-page":"119563","DOI":"10.1016\/j.ijpharm.2020.119563","volume":"586","author":"A Patil","year":"2020","unstructured":"Patil\u00a0A, Narvenker\u00a0R, Prabhakar\u00a0B, Shende\u00a0P (2020) Strategic consideration for effective chemotherapeutic transportation via transpapillary route in breast cancer. Int J Pharm 586:119563","journal-title":"Int J Pharm"},{"key":"5031_CR46","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.1021\/acs.molpharmaceut.6b00634","volume":"13","author":"K Dave","year":"2016","unstructured":"Dave\u00a0K, Alsharif\u00a0FM, Perumal\u00a0O (2016) Transpapillary (nipple) delivery of macromolecules to the breast: proof of concept study. Mol Pharm 13:3842\u20133851","journal-title":"Mol Pharm"},{"key":"5031_CR47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ijpharm.2018.04.033","volume":"545","author":"SL Kurtz","year":"2018","unstructured":"Kurtz\u00a0SL, Lawson\u00a0LB (2018) Determination of permeation pathways of hydrophilic or hydrophobic dyes through the mammary papilla. Int J Pharm 545:10\u201318","journal-title":"Int J Pharm"},{"key":"5031_CR48","doi-asserted-by":"publisher","first-page":"11810","DOI":"10.1038\/s41598-019-48144-x","volume":"9","author":"SL Kurtz","year":"2019","unstructured":"Kurtz\u00a0SL, Lawson\u00a0LB (2019) Nanoemulsions enhance in vitro transpapillary diffusion of model fluorescent dye nile red. Sci Rep 9:11810","journal-title":"Sci Rep"},{"key":"5031_CR49","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1021\/acs.molpharmaceut.9b00037","volume":"16","author":"SL Kurtz","year":"2019","unstructured":"Kurtz\u00a0SL, Lawson\u00a0LB (2019) Liposomes enhance dye localization within the mammary ducts of porcine nipples. Mol Pharm 16:1703\u20131713","journal-title":"Mol Pharm"},{"key":"5031_CR50","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jconrel.2020.04.016","volume":"323","author":"F Al-Zubaydi","year":"2020","unstructured":"Al-Zubaydi\u00a0F, Gao\u00a0D, Kakkar\u00a0D, Li\u00a0S, Adler\u00a0D, Holloway\u00a0J, Szekely\u00a0Z, Gu\u00a0Z, Chan\u00a0N, Kumar\u00a0S, Love\u00a0S, Sinko\u00a0PJ (2020) Breast intraductal nanoformulations for treating ductal carcinoma in situ i: exploring metal-ion complexation to slow ciclopirox release, enhance mammary persistence and efficacy. J\u00a0Control Release 323:71\u201382","journal-title":"J Control Release"},{"key":"5031_CR51","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1007\/s13346-021-00903-y","volume":"12","author":"F Al-Zubaydi","year":"2022","unstructured":"Al-Zubaydi\u00a0F, Gao\u00a0D, Kakkar\u00a0D, Li\u00a0S, Holloway\u00a0J, Szekely\u00a0Z, Chan\u00a0N, Kumar\u00a0S, Sabaawy\u00a0HE, Love\u00a0S, Sinko\u00a0PJ (2022) Breast intraductal nanoformulations for treating ductal carcinoma in situ ii: dose de-escalation using a\u00a0slow releasing\/slow bioconverting prodrug strategy. Drug Deliv Transl Res 12:240\u2013256","journal-title":"Drug Deliv Transl Res"},{"key":"5031_CR52","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.bcp.2016.07.005","volume":"116","author":"H Zhou","year":"2016","unstructured":"Zhou\u00a0H, Shang\u00a0C, Wang\u00a0M, Shen\u00a0T, Kong\u00a0L, Yu\u00a0C, Ye\u00a0Z, Luo\u00a0Y, Liu\u00a0L, Li\u00a0Y, Huang\u00a0S (2016) Ciclopirox olamine inhibits mtorc1 signaling by activation of ampk. Biochem Pharmacol 116:39\u201350","journal-title":"Biochem Pharmacol"},{"key":"5031_CR53","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ijpharm.2019.02.011","volume":"560","author":"G Mojeiko","year":"2019","unstructured":"Mojeiko\u00a0G, de Brito\u00a0M, Salata\u00a0GC, Lopes\u00a0LB (2019) Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer. Int J Pharm 560:365\u2013376","journal-title":"Int J Pharm"}],"container-title":["Die Dermatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-022-05031-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-022-05031-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-022-05031-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T22:04:55Z","timestamp":1666735495000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-022-05031-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,11]]},"references-count":53,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["5031"],"URL":"https:\/\/doi.org\/10.1007\/s00105-022-05031-3","relation":{},"ISSN":["2731-7005","2731-7013"],"issn-type":[{"type":"print","value":"2731-7005"},{"type":"electronic","value":"2731-7013"}],"subject":[],"published":{"date-parts":[[2022,7,11]]},"assertion":[{"value":"22 June 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"J.\u00a0Wohlrab hat in den letzten 5\u00a0Jahren Zuwendungen f\u00fcr wissenschaftliche Projekte, klinische Studien, Vortr\u00e4ge oder Beratung von folgenden Unternehmen erhalten: Abbott, AbbVie, Actelion, Allergika, Almirall, Aristo, Astellas, Bay Pharma, Beiersdorf, Biogen, BMS, Boehringer Ingelheim, Celltrion, Dermapharm, Evolva, Galderma, GSK, Helm, Hexal, InfectoPharm, Janssen-Cilag, Jenapharm, Johnson & Johnson, Klinge, Leo, Lilly, L\u2019Or\u00e9al, Medac, Medice, Mibe, MSD, Mylan, Novaliq, Novartis, Pierre Fabre, Pfizer, Regeneron, Skinomics, Stiefel, UCB, Wolff. T.H.\u00a0Luu Thi und A.\u00a0Eichner geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}