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Eine Kompressionstherapie k\u00f6nnte an dieser Lokalisation m\u00f6glicherweise eine sinnvolle erg\u00e4nzende Therapiema\u00dfnahme darstellen. Jedoch bestehen oft Bedenken, dass ein K\u00f6bner-Ph\u00e4nomen zu einer Verschlechterung des Hautbefundes f\u00fchren k\u00f6nnte. Daher sollten in dieser Studie die Effekte einer Kompressionstherapie auf Psoriasisplaques bei gleichzeitig bestehenden \u00d6demen an den Unterschenkeln untersucht werden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Patienten und Methoden<\/jats:title>\n                <jats:p>Es erfolgte ein Halbseitenversuch bei dem zus\u00e4tzlich zum \u201estandard of care\u201c eine 4\u2011w\u00f6chige Kompressionstherapie durchgef\u00fchrt wurde. Der prim\u00e4re Endpunkt war das klinische Ansprechen der Psoriasis-Plaques an den Unterschenkeln im Seitenvergleich gemessen mittels Lesion Severity Score (LSS) und der lokal betroffenen K\u00f6rperoberfl\u00e4che in Woche\u00a04 im Vergleich zum Ausgangsbefund. Sekund\u00e4re Endpunkte bezogen sich auf \u201epatient-reported outcomes\u201c.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Ergebnisse<\/jats:title>\n                <jats:p>In die finale Analyse gingen die Daten von 30\u00a0Patienten ein. Die mittleren LSS-Befunde sowie die subjektiven Schmerzen der Patienten zeigten in der rein deskriptiven Auswertung eine geringgradig st\u00e4rkere Verbesserung im Bereich des komprimierten im Vergleich zum nicht komprimierten Unterschenkel. Es ergaben sich keine Hinweise auf ein K\u00f6bner-Ph\u00e4nomen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Diskussion<\/jats:title>\n                <jats:p>Es handelt sich um die erste klinische Studie, die systematisch den Einfluss einer Kompressionstherapie auf Psoriasisplaques untersuchte. Im Untersuchungszeitraum von 4\u00a0Wochen ergaben sich zwar keine signifikanten Besserungen der Psoriasisplaques, allerdings auch keine Hinweise f\u00fcr eine Verschlechterung des Hautbefundes. Folglich kann eine anti\u00f6demat\u00f6se Kompressionstherapie bei Patienten mit Psoriasis unter Beachtung der grundlegenden Kontraindikationen ohne Komplikationen durchgef\u00fchrt werden.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00105-023-05155-0","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:21:44Z","timestamp":1683768104000},"page":"605-613","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Randomisierte klinische Studie zur Kompressionstherapie der Unterschenkel bei Patienten mit Psoriasis","Randomized clinical trial of compression therapy of the lower legs in patients with psoriasis"],"prefix":"10.1007","volume":"74","author":[{"given":"Frederik","family":"Krefting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"H\u00f6lsken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Moelleken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Dissemond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Sondermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"5155_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2340\/00015555-0770","volume":"90","author":"M Augustin","year":"2010","unstructured":"Augustin\u00a0M, Reich\u00a0K, Glaeske\u00a0G et al (2010) Co-morbidity and age-related prevalence of psoriasis: Analysis of health insurance data in Germany. 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M.\u00a0Moelleken erhielt Reisekostenunterst\u00fctzung f\u00fcr die Teilnahme an Kongressen und\/oder (Referenten\u2011)Honorare sowie Forschungsf\u00f6rderung von Adtec Healthcare und Urgo. J.\u00a0Dissemond erhielt Honorare f\u00fcr Vortr\u00e4ge, Beratungen und\/oder Studien von 3M, medi, Juzo, Lohmann\u00a0&\u00a0Rauscher, Thuasne und Urgo. W.\u00a0Sondermann erhielt Honorare f\u00fcr Vortr\u00e4ge, Beratungen und\/oder Studien von AbbVie, Almirall, Amgen, Bristol-Myers Squibb, Celgene, GSK, Janssen, LEO Pharma, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi Genzyme und UCB. S.\u00a0H\u00f6lsken gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"Alle beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der Ethik-Kommission Duisburg-Essen im Einklang mit nationalem Recht sowie gem\u00e4\u00df der Deklaration von Helsinki von 1975 (in der aktuellen, \u00fcberarbeiteten Fassung) durchgef\u00fchrt. Von allen beteiligten Patienten liegt eine Einverst\u00e4ndniserkl\u00e4rung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}