{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:24:07Z","timestamp":1770276247169,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018936","name":"Universit\u00e4tsklinikum Heidelberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das Skleromyx\u00f6dem Arndt-Gottron ist die systemische Variante des Lichen myxoedematosus. Kennzeichnend sind Muzinablagerungen im Bereich der Dermis mit Ausbildung von Papeln und fl\u00e4chigen Indurationen. Der Verlauf ist h\u00e4ufig chronisch progredient und extrakutane Manifestationen bzw. Komplikationen sind m\u00f6glich. Meist liegt eine monoklonale Gammopathie vor. Die Pathogenese ist unbekannt. Als effektive Therapieoption gelten hochdosierte intraven\u00f6se Immunglobuline (IVIg). Wir berichten \u00fcber eine Patientin mit Skleromyx\u00f6dem, bei der im Rahmen einer SARS-CoV-2-bedingten Therapieunterbrechung ein infektgetriggertes dermato-neurologisches Syndrom auftrat. Eine \u00e4hnliche Episode ereignete sich bereits 2\u00a0Jahre zuvor im Rahmen einer Influenza-A-Infektion gegen Ende des IVIg-Infusionsintervalls. Bei dem dermato-neurologischen Syndrom handelt es sich um eine besonders schwerwiegende, potenziell lebensbedrohliche, akute neurologische Komplikation mit Fiebersch\u00fcben, deliranter Symptomatik, epileptischen Anf\u00e4lle und Koma.<\/jats:p>","DOI":"10.1007\/s00105-023-05159-w","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:02:13Z","timestamp":1686117733000},"page":"618-620","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dermato-neurologisches Syndrom\u00a0\u2013 eine akute und lebensbedrohliche Komplikation des Skleromyx\u00f6dems Arndt-Gottron","Dermato-neuro syndrome\u2014an acute and life-threatening complication of scleromyxedema Arndt\u2013Gottron"],"prefix":"10.1007","volume":"74","author":[{"given":"Kai-Philipp","family":"Linse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Enk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"5159_CR1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1600-0560.2012.01882.x","volume":"39","author":"KE Fleming","year":"2012","unstructured":"Fleming\u00a0KE, Virmani\u00a0D, Sutton\u00a0E et al (2012) Scleromyxedema and the dermato-neuro syndrome: case report and review of the literature. 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K.-P.\u00a0Linse und J.\u00a0Hoffmann geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}