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Die Infektparameter zeigten sich stark erh\u00f6ht, es bestand kein Fieber. Wir stellten die Diagnose eines multilokul\u00e4ren Pyoderma gangraenosum. Nebenbefundlich konnte eine prim\u00e4r bili\u00e4re Cholangitis diagnostiziert werden. Wir f\u00fchrten eine systemische Kortikosteroidtherapie durch sowie eine Therapie mit Ursodesoxychols\u00e4ure. Hierunter kam es zu einer raschen Besserung. Ein PAPA-Syndrom konnte humangenetisch ausgeschlossen werden.<\/jats:p>","DOI":"10.1007\/s00105-023-05161-2","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T11:03:25Z","timestamp":1686913405000},"page":"538-542","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multilokul\u00e4res Pyoderma gangraenosum","Multilocular pyoderma gangrenosum"],"prefix":"10.1007","volume":"74","author":[{"given":"Julian","family":"K\u00f6gel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Berneburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid","family":"Karrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Niebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"5161_CR1","volume-title":"S1-Leitlinie Pyoderma gangrenosum","author":"AWMF","year":"2020","unstructured":"AWMF (2020) S1-Leitlinie Pyoderma gangrenosum"},{"issue":"4","key":"5161_CR2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s40257-017-0265-1","volume":"18","author":"M Cugno","year":"2017","unstructured":"Cugno\u00a0M, Borghi\u00a0A, Marzano\u00a0AV (2017) PAPA, PASH and PAPASH syndromes: pathophysiology, presentation and treatment. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}