{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:42:13Z","timestamp":1788309733536,"version":"build-2803163510"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum M\u00fcnster"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hydroxychloroquin wird bei Entz\u00fcndungserkrankungen eingesetzt und gilt als nebenwirkungsarm. Wir berichten \u00fcber eine Patientin, die sich mit einem schweren Exanthem nach Einnahme von Hydroxychloroquin vorstellte, das sie im Rahmen eines Lichen planopilaris erhielt. Basierend auf klinischen, laborchemischen und histologischen Befunden, wurde die Diagnose einer DRESS(\u201edrug reaction with eosinophilia and systemic symptoms\u201c)-artigen Arzneimittelreaktion gestellt. Der Fall illustriert, dass Hydroxychloroquin in seltenen F\u00e4llen zu schweren unerw\u00fcnschten Wirkungen f\u00fchren kann und Patienten, die dieses Medikament nehmen, sorgf\u00e4ltig aufgekl\u00e4rt werden m\u00fcssen.<\/jats:p>","DOI":"10.1007\/s00105-024-05294-y","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T15:03:26Z","timestamp":1706627006000},"page":"412-415","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydroxychloroquin\u00a0\u2013 nicht immer ein harmloses Medikament f\u00fcr den Off-label-Gebrauch in der Dermatologie","Hydroxychloroquine\u2014not always a\u00a0harmless drug for off label use in dermatology"],"prefix":"10.1007","volume":"75","author":[{"given":"Paloma","family":"Seidel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Spukti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Metze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"5294_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.5493\/wjem.v12.i3.44","volume":"12","author":"J Bajpai","year":"2022","unstructured":"Bajpai\u00a0J, Pradhan\u00a0A, Verma\u00a0AK, Kant\u00a0S (2022) Use of hydroxychloroquine and azithromycin combination to treat the COVID-19 infection. World J Exp Med 12:44\u201352","journal-title":"World J Exp Med"},{"key":"5294_CR2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/07853890.2020.1839959","volume":"53","author":"P Bansal","year":"2021","unstructured":"Bansal\u00a0P, Goyal\u00a0A, Cusick\u00a0A, Lahan\u00a0S, Dhaliwa\u00a0HS, Bhyan\u00a0P et\u00a0al (2021) Hydroxychloroquine: a\u00a0comprehensive review and its controversial role in coronavirus disease 2019. Ann Med 53:117\u2013134","journal-title":"Ann Med"},{"key":"5294_CR3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","volume":"124","author":"P Cacoub","year":"2011","unstructured":"Cacoub\u00a0P, Musette\u00a0P, Descamps\u00a0V, Meyer\u00a0O, Speirs\u00a0C, Finzi\u00a0L, Roujeau\u00a0JC (2011) The DRESS syndrome: a\u00a0literature review. Am J Med 124:588\u2013597","journal-title":"Am J Med"},{"key":"5294_CR4","doi-asserted-by":"crossref","unstructured":"Cho Y\u2011T, Yang C\u2011W, Chu C\u2011Y (2017) Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): an interplay among drugs, viruses, and immune system. Int J Mol Sci 18:","DOI":"10.3390\/ijms18061243"},{"issue":"5","key":"5294_CR5","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.jaip.2022.02.004","volume":"10","author":"N Hama","year":"2022","unstructured":"Hama\u00a0N, Abe\u00a0R, Gibson\u00a0A, Phillips\u00a0EJ (2022) Drug-Induced Hypersensitivity Syndrome (DIHS)\/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): clinical features and pathogenesis. J\u00a0Allergy Clin Immunol Pract 10(5):1155\u20131167.e5","journal-title":"J Allergy Clin Immunol Pract"},{"key":"5294_CR6","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s13671-021-00348-z","volume":"10","author":"EM Schunkert","year":"2021","unstructured":"Schunkert\u00a0EM, Divito\u00a0SJ (2021) Updates and insights in the diagnosis and management of DRESS syndrome. Curr Dermatol Rep 10:192\u2013204","journal-title":"Curr Dermatol Rep"},{"issue":"3","key":"5294_CR7","doi-asserted-by":"publisher","first-page":"e13380","DOI":"10.1111\/dth.13380","volume":"33","author":"RA Schwartz","year":"2020","unstructured":"Schwartz\u00a0RA, Janniger\u00a0CK (2020) Generalized pustular figurate erythema: a\u00a0newly delineated severe cutaneous drug reaction linked with hydroxychloroquine. Dermatol Ther 33(3):e13380","journal-title":"Dermatol Ther"},{"key":"5294_CR8","doi-asserted-by":"crossref","unstructured":"Stirton H, Shear NH, Dodiuk-Gad RP (2022) Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS)\/Drug-Induced Hypersensitivity Syndrome (DiHS)-readressing the DReSS. Biomedicines 10:","DOI":"10.3390\/biomedicines10050999"},{"key":"5294_CR9","unstructured":"https:\/\/www.theguardian.com\/world\/2020\/apr\/06\/hydroxychloroquine-trump-coronavirus-drug. Zugegriffen: 17. Nov. 2022"}],"container-title":["Die Dermatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-024-05294-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-024-05294-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-024-05294-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T07:02:36Z","timestamp":1714633356000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-024-05294-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,30]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["5294"],"URL":"https:\/\/doi.org\/10.1007\/s00105-024-05294-y","relation":{},"ISSN":["2731-7005","2731-7013"],"issn-type":[{"value":"2731-7005","type":"print"},{"value":"2731-7013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,30]]},"assertion":[{"value":"8 January 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"P.\u00a0Seidel, E.\u00a0Spukti, K.\u00a0Steinbrink, D.\u00a0Metze und M.\u00a0B\u00f6hm geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}