{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:13:52Z","timestamp":1784236432835,"version":"3.55.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Private Universit\u00e4t Witten\/Herdecke gGmbH"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Der paraneoplastische Pemphigus ist eine seltene, lebensbedrohliche Autoimmunerkrankung, die klinisch durch meist ausgedehnte und therapierefrakt\u00e4re Schleimhauterosionen und polymorphe Hautver\u00e4nderungen charakterisiert ist. Wir berichten hier \u00fcber eine 16-j\u00e4hrige Patientin mit isolierten oralen Erosionen, bei der zun\u00e4chst ein Schleimhautpemphigoid vermutet wurde und es unter Therapie mit Prednisolon und Dapson zu einer deutlichen Befundbesserung kam. Allerdings entwickelte die Patientin einige Monate sp\u00e4ter eine massive respiratorische Insuffizienz infolge einer Bronchiolitis obliterans, sodass eine Lungentransplantation geplant wurde. Im Rahmen der vorbereitenden Diagnostik wurde ein unizentrischer, abdominell lokalisierter Morbus Castleman diagnostiziert, was schlie\u00dflich zu der Diagnose eines paraneoplastischen Pemphigus mit Nachweis von Envoplakin-Autoantik\u00f6rpern f\u00fchrte. Durch die Tumorresektion und anschlie\u00dfende Lungentransplantation konnte ein guter Allgemeinzustand wiederhergestellt werden bei anhaltender mukokutaner Remission.<\/jats:p>","DOI":"10.1007\/s00105-024-05328-5","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T12:02:06Z","timestamp":1713960126000},"page":"641-646","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Morbus Castleman-assoziierter paraneoplastischer Pemphigus bei einer 16-j\u00e4hrigen Patientin","Paraneoplastic pemphigus with underlying Castleman\u2019s disease in a\u00a016-year-old girl"],"prefix":"10.1007","volume":"75","author":[{"given":"Sebastian T.","family":"Bender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Balakirski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Kteiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke C.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"issue":"25","key":"5328_CR1","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1056\/NEJM199012203232503","volume":"323","author":"GJ Anhalt","year":"1990","unstructured":"Anhalt\u00a0GJ, Kim\u00a0SC, Stanley\u00a0JR et\u00a0al (1990) Paraneoplastic pemphigus. 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Kteiche, E.\u00a0Schmidt und S.C.\u00a0Hofmann geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}