{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T13:10:14Z","timestamp":1750165814407,"version":"3.37.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"name":"Universit\u00e4tsklinikum Leipzig"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n          <jats:p>Eine 33-j\u00e4hrige Patientin mit Anti-NXP2(\u201enuclear matrix protein\u00a02\u201c)-positiver und eine 67-j\u00e4hrige Patientin mit TIF1-gamma(\u201etranscription intermediary factor\u00a01 gamma\u201c)-positiver Dermatomyositis entwickelten unter Systemtherapie mit Azathioprin bzw. Low-dose-Methylprednisolon und zyklischer Verabreichung von intraven\u00f6sen Immunglobulinen (IVIGs) schmerzhafte Ulzerationen im Gesichts- und K\u00f6rperstammbereich bzw. an den H\u00e4nden. In der laborchemischen Diagnostik blieb bei beiden Patientinnen der Anti-MDA5(\u201eanti-melanoma differentiation-associated protein\u00a05\u201c)-Antik\u00f6rperstatus negativ und die Kreatinkinase (CK) normwertig, die histopathologischen Untersuchungen erbrachten ein unspezifisches Ergebnis. Eine intensive topische Kortikosteroidtherapie der Klasse\u00a04 und Fortf\u00fchrung der immunsuppressiven bzw. immunmodulierenden Therapie f\u00fchrten zur Abheilung der ulzerativen Hautver\u00e4nderungen. Dieser Bericht soll f\u00fcr das seltene Auftreten kutaner Ulzerationen bei einer Anti-NXP2- bzw. Anti-TIF1-gamma-positiven Dermatomyositis sensibilisieren, da Ulzerationen mit einem schweren Krankheitsverlauf assoziiert sein k\u00f6nnen. In unseren beiden Patientenf\u00e4llen handelt es sich um eine ausschlie\u00dflich dermale Auspr\u00e4gung ohne sonstige Komplikationen.<\/jats:p>","DOI":"10.1007\/s00105-024-05462-0","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T15:50:49Z","timestamp":1737042649000},"page":"97-100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Kutane Ulzerationen bei Dermatomyositis","Cutaneous ulceration in dermatomyositis"],"prefix":"10.1007","volume":"76","author":[{"given":"Caroline","family":"Wald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan-Christoph","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Treudler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"5462_CR1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1002\/acr.22498","volume":"67","author":"NS Narang","year":"2015","unstructured":"Narang\u00a0NS, Casciola-Rosen\u00a0L, Li\u00a0S et\u00a0al (2015) Cutaneous ulceration in dermatomyositis: association with anti-melanoma differentiation-associated gene 5 antibodies and interstitial lung disease. Arthritis Care Res 67:667\u2013672","journal-title":"Arthritis Care Res"},{"key":"5462_CR2","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.jaad.2019.06.1309","volume":"82","author":"ME DeWane","year":"2020","unstructured":"DeWane\u00a0ME, Waldman\u00a0R, Lu\u00a0J (2020) Dermatomyositis: Clinical features and pathogenesis. J\u00a0Am Acad Dermatol 82:267\u2013281","journal-title":"J Am Acad Dermatol"},{"key":"5462_CR3","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fped.2018.00284","volume":"6","author":"C Papadopoulou","year":"2018","unstructured":"Papadopoulou\u00a0C, McCann\u00a0LJ (2018) The Vasculopathy of Juvenile Dermatomyositis. Front Pediatr 6:284","journal-title":"Front Pediatr"},{"key":"5462_CR4","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12016-015-8496-5","volume":"51","author":"Y Muro","year":"2016","unstructured":"Muro\u00a0Y, Sugiura\u00a0K, Akiyama\u00a0M (2016) Cutaneous Manifestations in Dermatomyositis: Key Clinical and Serological Features\u2011a Comprehensive Review. Clin Rev Allergy Immunol 51:293\u2013302","journal-title":"Clin Rev Allergy Immunol"},{"key":"5462_CR5","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.3899\/jrheum.200399","volume":"48","author":"MZ Al Awqati","year":"2021","unstructured":"Al Awqati\u00a0MZ, Sluzevich\u00a0JC, Berianu\u00a0F (2021) Ulcerative Paraneoplastic Dermatomyositis in the Setting of Positive Transcriptional Intermediary Factor 1\u2011\u03b3 Antibody. J\u00a0Rheumatol 48:1340","journal-title":"J Rheumatol"},{"key":"5462_CR6","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.12998\/wjcc.v10.i11.3579","volume":"10","author":"Y-T Wang","year":"2022","unstructured":"Wang\u00a0Y\u2011T, Zhang\u00a0Y, Tang\u00a0T et\u00a0al (2022) Anti-nuclear matrix protein 2+ juvenile dermatomyositis with severe skin ulcer and infection: A\u00a0case report and literature review. World J Clin Cases 10:3579\u20133586","journal-title":"World J Clin Cases"},{"key":"5462_CR7","doi-asserted-by":"crossref","unstructured":"Rosseels W, Vulsteke JB, Bosisio F et\u00a0al (2023) Rapidly progressive erosions and ulcerations in a\u00a0patient with cancer-associated anti-TIF-1\u03b3\/\u03b1 and anti-U1 RNP-positive dermatomyositis: A\u00a0case report. J\u00a0Eur Acad Dermatol Venereol","DOI":"10.1111\/jdv.19339"},{"key":"5462_CR8","doi-asserted-by":"publisher","first-page":"436","DOI":"10.21037\/atm-20-5252","volume":"9","author":"RL Castillo","year":"2021","unstructured":"Castillo\u00a0RL, Femia\u00a0AN (2021) Covert clues: the non-hallmark cutaneous manifestations of dermatomyositis. Ann Transl Med 9:436","journal-title":"Ann Transl Med"},{"key":"5462_CR9","doi-asserted-by":"publisher","first-page":"773352","DOI":"10.3389\/fimmu.2021.773352","volume":"12","author":"A Nombel","year":"2021","unstructured":"Nombel\u00a0A, Fabien\u00a0N, Coutant\u00a0F (2021) Dermatomyositis With Anti-MDA5 Antibodies: Bioclinical Features, Pathogenesis and Emerging Therapies. Front Immunol 12:773352","journal-title":"Front Immunol"}],"container-title":["Die Dermatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-024-05462-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-024-05462-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-024-05462-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T13:32:30Z","timestamp":1738848750000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-024-05462-0"}},"subtitle":["Fallberichte mit positivem Anti-NXP2\/Anti-TIF1-gamma-Antik\u00f6rper-Status","Case reports with positive anti-NXP-2\/anti-TIF1-gamma antibody status"],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["5462"],"URL":"https:\/\/doi.org\/10.1007\/s00105-024-05462-0","relation":{},"ISSN":["2731-7005","2731-7013"],"issn-type":[{"type":"print","value":"2731-7005"},{"type":"electronic","value":"2731-7013"}],"subject":[],"published":{"date-parts":[[2025,1,16]]},"assertion":[{"value":"7 December 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"C.\u00a0Wald, J.-C.\u00a0Simon und R.\u00a0Treudler geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}