{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:13:20Z","timestamp":1767140000759,"version":"build-2238731810"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00105-025-05484-2","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T10:12:50Z","timestamp":1741342370000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemtherapien bei p\u00e4diatrischen Patient:innen mit\u00a0Ichthyose","Systemic therapies for pediatric patients with ichthyosis"],"prefix":"10.1007","volume":"76","author":[{"given":"Laura","family":"Trefzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kira","family":"S\u00fc\u00dfmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"key":"5484_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.0205","author":"V Oji","year":"2010","unstructured":"Oji\u00a0V, Tadini\u00a0G, Akiyama\u00a0M et\u00a0al (2010) Revised nomenclature and classification of inherited ichthyoses: Results of the First Ichthyosis Consensus Conference in Sor\u00e8ze 2009. J\u00a0Am Acad Dermatol. https:\/\/doi.org\/10.1016\/j.jaad.2009.11.0205","journal-title":"J Am Acad Dermatol"},{"key":"5484_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-023-05257-9","author":"K S\u00fc\u00dfmuth","year":"2024","unstructured":"S\u00fc\u00dfmuth\u00a0K, Magnolo\u00a0N, Oji\u00a0V, Koll\u00a0PO, Striegel\u00a0A, Tantcheva-Po\u00f3r\u00a0I (2024) Entz\u00fcndliche Dermatosen im Kindes- und Jugendalter: Diagnostische und therapeutische Besonderheiten anhand der atopischen Dermatitis und der Psoriasis. Dermatologie (heidelb). https:\/\/doi.org\/10.1007\/s00105-023-05257-9","journal-title":"Dermatologie (heidelb)"},{"key":"5484_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18043","author":"E Cuperus","year":"2022","unstructured":"Cuperus\u00a0E, Bygum\u00a0A, Boeckmann\u00a0L et\u00a0al (2022) Proposal for a\u00a06-step approach for differential diagnosis of neonatal erythroderma. J\u00a0Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.18043","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5484_CR4","unstructured":"Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). https:\/\/register.awmf.org\/de\/leitlinien\/detail\/013-043. Zugegriffen: 27. Jan. 2025"},{"key":"5484_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20482","author":"LK Trefzer","year":"2024","unstructured":"Trefzer\u00a0LK, Davidovic\u00a0M, Li\u00a0D et\u00a0al (2024) Systemic anti-inflammatory therapy in congenital ichthyosis: Real-world experience in a\u00a0series of 22\u00a0cases. J\u00a0Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.20482","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5484_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-2","author":"H Dufresne","year":"2013","unstructured":"Dufresne\u00a0H, Hadj-Rabia\u00a0S, M\u00e9ni\u00a0C, Sibaud\u00a0V, Bodemer\u00a0C, Ta\u00efeb\u00a0C (2013) Family burden in inherited ichthyosis: creation of a\u00a0specific questionnaire. Orphanet J Rare Dis. https:\/\/doi.org\/10.1186\/1750-1172-8-2","journal-title":"Orphanet J Rare Dis"},{"key":"5484_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae436","author":"FCAP van Veen","year":"2024","unstructured":"van Veen\u00a0FCAP, Rossel\u00a0SVJ, Steijlen\u00a0PM et\u00a0al (2024) The perceived quality of life in adult patients with inherited ichthyosis: a\u00a0qualitative interview study. Br J Dermatol. https:\/\/doi.org\/10.1093\/bjd\/ljae436","journal-title":"Br J Dermatol"},{"key":"5484_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19804","author":"C Klein","year":"2024","unstructured":"Klein\u00a0C, Oji\u00a0V, Sommer\u00a0R et\u00a0al (2024) Personal, financial and time burden in inherited ichthyoses: A\u00a0survey of 144 patients in a\u00a0university-based setting. J\u00a0Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.19804","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5484_CR9","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llae382","author":"KL Curtis","year":"2025","unstructured":"Curtis\u00a0KL, Zeldin\u00a0S, Lipner\u00a0SR (2025) Congenital ichthyosis is associated with cutaneous infections in a\u00a0case-control study of 2260 patients. Clin Exp Dermatol. https:\/\/doi.org\/10.1093\/ced\/llae382","journal-title":"Clin Exp Dermatol"},{"key":"5484_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17203","author":"J Mazereeuw-Hautier","year":"2019","unstructured":"Mazereeuw-Hautier\u00a0J, Vahlquist\u00a0A, Traupe\u00a0H et\u00a0al (2019) Management of congenital ichthyoses: European guidelines of care, part one. Br J Dermatol. https:\/\/doi.org\/10.1111\/bjd.17203","journal-title":"Br J Dermatol"},{"key":"5484_CR11","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16882","author":"J Mazereeuw-Hautier","year":"2019","unstructured":"Mazereeuw-Hautier\u00a0J, Hern\u00e1ndez-Mart\u00edn\u00a0A, O\u2019Toole\u00a0EA et\u00a0al (2019) Management of congenital ichthyoses: European guidelines of care, part two. Br J Dermatol. https:\/\/doi.org\/10.1111\/bjd.16882","journal-title":"Br J Dermatol"},{"key":"5484_CR12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01527.x","author":"JJ Digiovanna","year":"2013","unstructured":"Digiovanna\u00a0JJ, Mauro\u00a0T, Milstone\u00a0LM, Schmuth\u00a0M, Toro\u00a0JR (2013) Systemic retinoids in the management of ichthyoses and related skin types. Dermatol Ther. https:\/\/doi.org\/10.1111\/j.1529-8019.2012.01527.x","journal-title":"Dermatol Ther"},{"key":"5484_CR13","doi-asserted-by":"publisher","DOI":"10.1159\/000533934","author":"J Clabbers","year":"2024","unstructured":"Clabbers\u00a0J, van Oosten\u00a0NV, Bolling\u00a0M et\u00a0al (2024) Alitretinoin as a\u00a0Treatment Modality for Ichthyosis in Women of Childbearing Age: A\u00a0Case Series and Review of the Literature. Dermatology. https:\/\/doi.org\/10.1159\/000533934","journal-title":"Dermatology"},{"key":"5484_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.03.082","author":"A Cave","year":"2020","unstructured":"Cave\u00a0A, Plumptre\u00a0I, Mellerio\u00a0JE, Martinez\u00a0AE, Kinsler\u00a0VA (2020) The adverse effect profile of acitretin in a\u00a0pediatric dermatology population-Longitudinal cohort study and recommendations for monitoring. J\u00a0Am Acad Dermatol. https:\/\/doi.org\/10.1016\/j.jaad.2020.03.082","journal-title":"J Am Acad Dermatol"},{"key":"5484_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.5863\/1551-6776-23.2.164","volume":"23","author":"K Damodaran","year":"2018","unstructured":"Damodaran\u00a0K, Bhutada\u00a0A, Rastogi\u00a0S (2018) A\u00a0Unique Preparation and Delivery Method for Acitretin for Neonatal Harlequin Ichthyosis. J\u00a0Pediatr Pharmacol Ther 23:164\u2013167. https:\/\/doi.org\/10.5863\/1551-6776-23.2.164","journal-title":"J Pediatr Pharmacol Ther"},{"key":"5484_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22224.x","author":"CJ Barnes","year":"2005","unstructured":"Barnes\u00a0CJ, Eichenfield\u00a0LF, Lee\u00a0J, Cunningham\u00a0BB (2005) A\u00a0practical approach for the use of oral isotretinoin for infantile acne. Pediatr Dermatol. https:\/\/doi.org\/10.1111\/j.1525-1470.2005.22224.x","journal-title":"Pediatr Dermatol"},{"key":"5484_CR17","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15613","author":"AM De Palma","year":"2019","unstructured":"De Palma\u00a0AM, Mazereeuw-Hautier\u00a0J, Giehl\u00a0K et\u00a0al (2019) Burden of itch in ichthyosis: a\u00a0multicentre study in 94\u00a0patients. J\u00a0Eur Acad Dermatol Venereol. https:\/\/doi.org\/10.1111\/jdv.15613","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5484_CR18","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02430-6","author":"MDW Joosten","year":"2022","unstructured":"Joosten\u00a0MDW, Clabbers\u00a0JMK, Jonca\u00a0N, Mazereeuw-Hautier\u00a0J, Gosty\u0144ski\u00a0AH (2022) New developments in the molecular treatment of ichthyosis: review of the literature. Orphanet J Rare Dis. https:\/\/doi.org\/10.1186\/s13023-022-02430-6","journal-title":"Orphanet J Rare Dis"},{"key":"5484_CR19","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14197","author":"MKY Chen","year":"2024","unstructured":"Chen\u00a0MKY, Flanagan\u00a0AL, Sebaratnam\u00a0DF, Gu\u00a0Y (2024) Biologics for inherited disorders of keratinisation: A\u00a0systematic review. Australas J Dermatol. https:\/\/doi.org\/10.1111\/ajd.14197","journal-title":"Australas J Dermatol"},{"key":"5484_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02325-3","author":"R Lefferdink","year":"2023","unstructured":"Lefferdink\u00a0R, Rangel\u00a0SM, Chima\u00a0M et\u00a0al (2023) Secukinumab responses vary across the spectrum of congenital ichthyosis in adults. Arch Dermatol Res. https:\/\/doi.org\/10.1007\/s00403-022-02325-3","journal-title":"Arch Dermatol Res"},{"key":"5484_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae420","author":"J Mazereeuw-Hautier","year":"2025","unstructured":"Mazereeuw-Hautier\u00a0J, Granier Tournier\u00a0C, Hernandez-Martin\u00a0A et\u00a0al (2025) Biologics in congenital ichthyosis: are they effective? Br J Dermatol. https:\/\/doi.org\/10.1093\/bjd\/ljae420","journal-title":"Br J Dermatol"},{"key":"5484_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.03.021","author":"K Malik","year":"2019","unstructured":"Malik\u00a0K, He\u00a0H, Huynh\u00a0TN et\u00a0al (2019) Ichthyosis molecular fingerprinting shows profound TH17 skewing and a\u00a0unique barrier genomic signature. J\u00a0Allergy Clin Immunol. https:\/\/doi.org\/10.1016\/j.jaci.2018.03.021","journal-title":"J Allergy Clin Immunol"},{"key":"5484_CR23","doi-asserted-by":"crossref","unstructured":"S\u00fc\u00dfmuth K, Traupe H, Loser K et\u00a0al (2021) Response to dupilumab in two children with Netherton syndrome: Improvement of pruritus and scaling. J\u00a0Eur Acad Dermatol Venereol: 152\u2013155","DOI":"10.1111\/jdv.16883"},{"key":"5484_CR24","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14590","author":"F Cicek","year":"2021","unstructured":"Cicek\u00a0F, Cekic\u00a0S, Kilic\u00a0SS (2021) Infliximab therapy in an infant with Netherton syndrome. Pediatr Dermatol. https:\/\/doi.org\/10.1111\/pde.14590","journal-title":"Pediatr Dermatol"},{"key":"5484_CR25","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18892","author":"S Volc","year":"2020","unstructured":"Volc\u00a0S, Maier\u00a0L, Gritsch\u00a0A, Aichelburg\u00a0MC, Volc-Platzer\u00a0B (2020) Successful treatment of Netherton syndrome with ustekinumab in a\u00a015-year-old girl. Br J Dermatol. https:\/\/doi.org\/10.1111\/bjd.18892","journal-title":"Br J Dermatol"},{"key":"5484_CR26","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4126","author":"C Greco","year":"2020","unstructured":"Greco\u00a0C, Leclerc-Mercier\u00a0S, Chaumon\u00a0S et\u00a0al (2020) Use of Epidermal Growth Factor Receptor Inhibitor Erlotinib to Treat Palmoplantar Keratoderma in Patients With Olmsted Syndrome Caused by TRPV3 Mutations. JAMA Dermatol. https:\/\/doi.org\/10.1001\/jamadermatol.2019.4126","journal-title":"JAMA Dermatol"},{"issue":"1","key":"5484_CR27","doi-asserted-by":"publisher","first-page":"103247","DOI":"10.1016\/j.annder.2024.103247","volume":"151","author":"M Severino-Freire","year":"2024","unstructured":"Severino-Freire\u00a0M, Granier Tournier\u00a0C, Chiaverini\u00a0C et\u00a0al (2024) French national protocol for the management of congenital ichthyosis. Ann Dermatol Venereol 151(1):103247. https:\/\/doi.org\/10.1016\/j.annder.2024.103247","journal-title":"Ann Dermatol Venereol"},{"key":"5484_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.08.047","author":"K S\u00fc\u00dfmuth","year":"2018","unstructured":"S\u00fc\u00dfmuth\u00a0K, Gruber\u00a0R, Rodriguez\u00a0E et\u00a0al (2018) Increased Prevalence of Filaggrin Deficiency in 51\u00a0Patients with Recessive X\u2011Linked Ichthyosis Presenting for Dermatological Examination. J\u00a0Invest Dermatol. https:\/\/doi.org\/10.1016\/j.jid.2017.08.047","journal-title":"J Invest Dermatol"},{"key":"5484_CR29","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01239-4","author":"SA Koutsoukos","year":"2024","unstructured":"Koutsoukos\u00a0SA, Bilousova\u00a0G (2024) Highlights of Gene and Cell Therapy for Epidermolysis Bullosa and Ichthyosis. Dermatol Ther (Heidelb). https:\/\/doi.org\/10.1007\/s13555-024-01239-4","journal-title":"Dermatol Ther (Heidelb)"}],"updated-by":[{"DOI":"10.1007\/s00105-025-05608-8","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000}}],"container-title":["Die Dermatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-025-05484-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-025-05484-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-025-05484-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T06:34:32Z","timestamp":1765002872000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-025-05484-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["5484"],"URL":"https:\/\/doi.org\/10.1007\/s00105-025-05484-2","relation":{},"ISSN":["2731-7005","2731-7013"],"issn-type":[{"value":"2731-7005","type":"print"},{"value":"2731-7013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"4 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Im Abschnitt Differenzialdiagnostische Aspekte wurde die MIM-Nummer des SAM-Syndroms f\u00e4lschlich als MIM#516508 angegeben. Die korrekte Nummer lautet MIM#615508; der Originalartikel wurde entsprechend korrigiert.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2025","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Erratum","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Zu diesem Beitrag wurde ein Erratum ver\u00f6ffentlicht:","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00105-025-05608-8","URL":"https:\/\/doi.org\/10.1007\/s00105-025-05608-8","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"L.\u00a0Trefzer erhielt ein Stipendiat der Else-Kr\u00f6ner-Fresenius-Stiftung und ist derzeit Stipendiatin des Clinician Scientist Programms Berta-Ottenstein der Universit\u00e4t Freiburg; Sie erhielt Reisekostenzusch\u00fcsse von Sun Pharma, Referentenhonorare vom Psoriasis Netzwerk Deutschland, von Lilly GmbH Deutschland und Sanofi Regeneron. K.\u00a0S\u00fc\u00dfmuth gibt an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autorinnen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}