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MLP kann sowohl die Mundschleimhaut (oraler Lichen planus [OLP]) als auch die Genitalschleimhaut betreffen. Patienten mit OLP k\u00f6nnen unterschiedliche Schweregrade aufweisen. Insbesondere Patienten, die von einer erosiven\/ulzerativen Form betroffen sind, stellen in der Regel eine therapeutische Herausforderung dar, da I)\u00a0es bisher keine von der FDA (Food and Drug Administration)\/EMA (European Medicines Agency) zugelassenen Medikamente gibt und\u00a0II) die Krankheit h\u00e4ufig eine Therapieresistenz aufweist. K\u00fcrzlich ver\u00f6ffentlichte Studien zur Immunpathogenese beschreiben eine \u00fcberwiegende Rolle der durch Interferon\u2011\u03b3 ausgel\u00f6sten Entz\u00fcndung, doch viele Aspekte der Krankheit sind noch unbekannt. Dementsprechend stehen bislang prim\u00e4r symptomatische Therapien zur Verf\u00fcgung. Neben topischen Glukokortikoiden stellen Retinoide in topischer und systemischer Form sowie systemische Glukokortikoide die etablierten Erstlinientherapien dar. Eine Vielzahl von Zweit- und Drittlinientherapien zeigt, dass bisher keine standardm\u00e4\u00dfige Behandlung existiert. Bei den neuen Therapien sind Januskinaseinhibitoren sowie monoklonale Antik\u00f6rper hervorzuheben, die zuk\u00fcnftig das Therapiespektrum f\u00fcr OLP erweitern k\u00f6nnten. Hierf\u00fcr sind jedoch prospektive, placebokontrollierte Studien zuk\u00fcnftig notwendig. Auch alternative und erg\u00e4nzende Behandlungen wie pflanzliche Therapien, Lichttherapie sowie \u201eplatelet-rich plasma\u201c (PRP) und \u201einjectable platelet-rich fibrin\u201c (i-PRF), werden in der Literatur beschrieben. In diesem Beitrag diskutieren wir die aktuellen therapeutischen Optionen f\u00fcr diese schwer zu behandelnde Krankheit.<\/jats:p>","DOI":"10.1007\/s00105-025-05540-x","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:29:24Z","timestamp":1752593364000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapie des oralen Lichen planus\u00a0\u2013 eine aktuelle \u00dcbersicht","Treatment of oral lichen planus\u2014a\u00a0review"],"prefix":"10.1007","volume":"76","author":[{"given":"Khava","family":"Abdusalamova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzan","family":"Solimani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"issue":"6","key":"5540_CR1","first-page":"864","volume":"19","author":"F Solimani","year":"2021","unstructured":"Solimani\u00a0F, Forchhammer\u00a0S, Schloegl\u00a0A, Ghoreschi\u00a0K, Meier\u00a0K (2021) Lichen planus \u2013 ein Klinikleitfaden. 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