{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:25:54Z","timestamp":1768400754439,"version":"3.49.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"DOI":"10.13039\/501100018935","name":"Universit\u00e4tsklinikum Erlangen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Dermatologie"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Dieser Fallbericht beschreibt einen 58-j\u00e4hrigen Patienten mit linearer Porokeratose, auf deren Basis sich kutane Plattenepithelkarzinome entwickelten. Porokeratose ist eine seltene Keratinisierungsst\u00f6rung, die mit einem Risiko f\u00fcr eine maligne Transformation einhergeht. Der Patient stellte sich zun\u00e4chst mit wiederkehrenden Erosionen und Ulzerationen vor. Nachdem er zun\u00e4chst sehr zur\u00fcckhaltend war, \u00e4rztliche Hilfe in Anspruch zu nehmen, willigte er schlie\u00dflich in die Entnahme von Probebiopsien ein. Diese best\u00e4tigten Plattenepithelkarzinome in mehreren L\u00e4sionen sowie ein Bowen-Karzinom. Diese wurden erfolgreich exzidiert, und der Patient entschied sich postoperativ f\u00fcr eine sekund\u00e4re Wundheilung. Aufgrund ihres Potenzials zur malignen Transformation erfordern Porokeratosen oft eine sorgf\u00e4ltige klinische \u00dcberwachung. Sie sind typischerweise durch hyperkeratotische L\u00e4sionen gekennzeichnet, die im Laufe der Zeit fortschreiten k\u00f6nnen. Obwohl es verschiedene Behandlungsm\u00f6glichkeiten der Porokeratose gibt, ist deren langfristige Wirksamkeit begrenzt. Dieser Fall unterstreicht die Bedeutung von fr\u00fchzeitigen Biopsien bei nicht heilenden Wunden sowie die Notwendigkeit der Edukation von Patienten und regelm\u00e4\u00dfiger Nachuntersuchungen, um das Hautkrebsrisiko zu reduzieren.<\/jats:p>","DOI":"10.1007\/s00105-025-05565-2","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T08:27:45Z","timestamp":1755592065000},"page":"33-36","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Plattenepithelkarzinome auf einer linearen Porokeratose","Multiple squamous cell carcinomas arising in linear porokeratosis"],"prefix":"10.1007","volume":"77","author":[{"given":"Dorothee A.","family":"Busch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carola","family":"Berking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schliep","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Erfurt-Berge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"5565_CR1","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.36849\/JDD.7775","volume":"22","author":"F Casale","year":"2023","unstructured":"Casale\u00a0F, Walters\u00a0N, Peach\u00a0A, Dong\u00a0J (2023) Efficacy of Topical Cholesterol and Statin Combination Therapy in the Treatment of Porokeratosis: A\u00a0Systematic Review and Meta-Analysis. J\u00a0Drugs Dermatol 22:1160\u20131165. https:\/\/doi.org\/10.36849\/JDD.7775","journal-title":"J Drugs Dermatol"},{"key":"5565_CR2","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/jdv.18587","volume":"37","author":"R Inci","year":"2023","unstructured":"Inci\u00a0R, Zagoras\u00a0T, Kantere\u00a0D et\u00a0al (2023) Porokeratosis is one of the most common genodermatoses and is associated with an increased risk of keratinocyte cancer and melanoma. J\u00a0Eur Acad Dermatol Venereol 37:420\u2013427. https:\/\/doi.org\/10.1111\/jdv.18587","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5565_CR3","doi-asserted-by":"publisher","first-page":"e13083","DOI":"10.7759\/cureus.13083","volume":"13","author":"T Novice","year":"2021","unstructured":"Novice\u00a0T, Nakamura\u00a0M, Helfrich\u00a0Y (2021) The Malignancy Potential of Porokeratosis: A\u00a0Single-Center Retrospective Study. Cureus 13:e13083. https:\/\/doi.org\/10.7759\/cureus.13083","journal-title":"Cureus"},{"key":"5565_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13121176","author":"P Pietkiewicz","year":"2023","unstructured":"Pietkiewicz\u00a0P, Korecka\u00a0K, Salwowska\u00a0N et\u00a0al (2023) Porokeratoses\u2014A Comprehensive Review on the Genetics and Metabolomics, Imaging Methods and Management of Common Clinical Variants. Metabolites. https:\/\/doi.org\/10.3390\/metabo13121176","journal-title":"Metabolites"},{"key":"5565_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1524-4725.1996.tb00327.x","volume":"22","author":"M Sasson","year":"1996","unstructured":"Sasson\u00a0M, Krain\u00a0AD (1996) Porokeratosis and cutaneous malignancy. A\u00a0review. Dermatol Surg 22:339\u2013342. https:\/\/doi.org\/10.1111\/j.1524-4725.1996.tb00327.x","journal-title":"Dermatol Surg"},{"key":"5565_CR6","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1468-3083.2011.04275.x","volume":"26","author":"P Sertznig","year":"2012","unstructured":"Sertznig\u00a0P, von Felbert\u00a0V, Megahed\u00a0M (2012) Porokeratosis: present concepts. J\u00a0Eur Acad Dermatol Venereol 26:404\u2013412. https:\/\/doi.org\/10.1111\/j.1468-3083.2011.04275.x","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5565_CR7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.ad.2020.03.005","volume":"111","author":"P Vargas-Mora","year":"2020","unstructured":"Vargas-Mora\u00a0P, Morgado-Carrasco\u00a0D, Fust\u00e0-Novell\u00a0X (2020) Porokeratosis: A\u00a0Review of Its Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment. Actas Dermosifiliogr 111:545\u2013560. https:\/\/doi.org\/10.1016\/j.ad.2020.03.005","journal-title":"Actas Dermosifiliogr"},{"key":"5565_CR8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s40257-017-0271-3","volume":"18","author":"T Weidner","year":"2017","unstructured":"Weidner\u00a0T, Illing\u00a0T, Miguel\u00a0D, Elsner\u00a0P (2017) Treatment of Porokeratosis: A\u00a0Systematic Review. Am J Clin Dermatol 18:435\u2013449. https:\/\/doi.org\/10.1007\/s40257-017-0271-3","journal-title":"Am J Clin Dermatol"},{"key":"5565_CR9","volume-title":"Porokeratosis. StatPearls (Internet). Treasure Isl","author":"GM Williams","year":"2022","unstructured":"Williams\u00a0GM, Fillman\u00a0EP (2022) Porokeratosis. StatPearls (Internet). Treasure Isl. StatPearls Publ"}],"container-title":["Die Dermatologie"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-025-05565-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00105-025-05565-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00105-025-05565-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:52:34Z","timestamp":1768380754000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00105-025-05565-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5565"],"URL":"https:\/\/doi.org\/10.1007\/s00105-025-05565-2","relation":{},"ISSN":["2731-7005","2731-7013"],"issn-type":[{"value":"2731-7005","type":"print"},{"value":"2731-7013","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"28 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Einhaltung ethischer Richtlinien"}},{"value":"D.A.\u00a0Busch, C.\u00a0Berking, S.\u00a0Schliep und C.\u00a0Erfurt-Berge geben an, dass kein Interessenkonflikt besteht.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}},{"value":"F\u00fcr diesen Beitrag wurden von den Autor\/-innen keine Studien an Menschen oder Tieren durchgef\u00fchrt. F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. F\u00fcr Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, \u00fcber die Patient\/-innen zu identifizieren sind, liegt von ihnen und\/oder ihren gesetzlichen Vertretern\/Vertreterinnen eine schriftliche Einwilligung vor.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}