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Kennzeichnend ist eine Kombination aus Vaskulopathie und entz\u00fcndlicher Fibrose von Haut und Organen. Die Erkrankung kann sich sehr heterogen pr\u00e4sentieren, was die Diagnosestellung erschwert und in der \u00dcberwachung und Therapie ber\u00fccksichtigt werden muss. Dank Forschungsresultaten der letzten Jahrzehnte stehen mittlerweile deutlich mehr Medikamente f\u00fcr die Behandlung der SSc zur Verf\u00fcgung. Die Wahl der Therapie ist bei jedem Erkrankungsfall an die individuelle Auspr\u00e4gung anzupassen. Der vorliegende Beitrag bietet einen \u00dcberblick \u00fcber die verschiedenen Krankheitsmanifestationen und Behandlungsm\u00f6glichkeiten bei SSc. F\u00fcr eine bestm\u00f6gliche Betreuung betroffener Patienten ist eine gute haus\u00e4rztliche und rheumatologische Zusammenarbeit essenziell. Weitere internistische Fach\u00e4rzte (Pneumologen, Gastroenterologen, Kardiologen, Nephrologen) m\u00fcssen je nach Organbefall hinzugezogen werden.<\/jats:p>","DOI":"10.1007\/s00105-025-05622-w","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T15:14:55Z","timestamp":1765466095000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Systemische Sklerose","Systemic sclerosis"],"prefix":"10.1007","volume":"77","author":[{"given":"Caroline","family":"Evers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Distler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Distler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"issue":"7","key":"5622_CR1","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1093\/rheumatology\/keab190","volume":"60","author":"M Bairkdar","year":"2021","unstructured":"Bairkdar\u00a0M et\u00a0al (2021) Incidence and prevalence of systemic sclerosis globally: a\u00a0comprehensive systematic review and meta-analysis. 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